Sandro Pasquali
University of Padua
CancerInternal medicineRadiologySoft tissueSurgeryOncologyRandomized controlled trialSentinel nodeHazard ratioBiopsyMelanomaSarcomaSoft tissue sarcomaSurgical oncologySentinel lymph nodeLymphadenectomyLymph nodeCutaneous melanomaIn patientGeneral surgeryMedicine
Publications 120
Background Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of p53 facilitates its XPO1-mediated nuclear export, thus limiting p53 tumor suppressor functions. Consequently, nuclear export is a rational target in DDLPS. We directly compared the antitumor activity of the first-in class XPO1 inhibitor selinexor and doxorubicin, the standard fron...
#1Andraz PerhavecH-Index: 1
#1Andraz PerhavecH-Index: 8
Last. Marco FioreH-Index: 68
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BACKGROUND The outcome of patients with retroperitoneal sarcomas (RPS) depends mainly on tumor biology and completeness of surgical resection. However, some patients are deemed not resectable for various reasons. This study analyzed a series of primary RPS patients to describe rate and reasons of primary inoperability at a large referral center. METHODS All consecutive patients affected by primary localized RPS referred for surgical treatment at our institution between January 1, 2013 and Decemb...
2 CitationsSource
#1Marco FioreH-Index: 68
#2Cinzia BrunelliH-Index: 40
Last. Alessandro GronchiH-Index: 88
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Primary retroperitoneal sarcoma (RPS) may require multivisceral resection (MVR). Clinical outcome (morbidity and renal function) and quality of life (QoL) are not as well reported as the oncologic outcome. Patients with primary RPS who underwent surgery between 2014 and 2016 were prospectively enrolled in an observational longitudinal study. At baseline, then at 4 and 12 months, the study measured Clavien–Dindo morbidity, estimated glomerular filtration rate (EGFR), EORTC QLQ-C30, QLQ-CR29, DN4 ...
1 CitationsSource
#1Fabio TirottaH-Index: 3
#2James HodsonH-Index: 28
Last. L. Max AlmondH-Index: 3
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Abstract Introduction Studies reporting outcomes of liver resection for sarcoma metastases (LRSM) typically include gastrointestinal stromal tumours (GIST), or pooled analyses of “non-colorectal liver metastases”, which do not reflect the subgroup of patients with sarcomatous liver metastases. This study aimed to perform a systematic review to evaluate oncological and surgical outcomes in patients undergoing LRSM, and to report new data from two tertiary institutions. Methods MEDLINE and the Coc...
#1James GlasbeyH-Index: 16
Last. Christl A. DonnellyH-Index: 93
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Aim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method: This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergo...
#1Anna Maria FrezzaH-Index: 16
#2Marta Sbaraglia (UNIPD: University of Padua)H-Index: 14
Last. Alessandro GronchiH-Index: 88
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INTRODUCTION: This case-series is aimed to describe the natural history of epithelioid sarcoma (ES) and to provide insights into the differential clinical behaviour of its two variants ("classic-type" and "proximal-type"). The value of a subtype-adapted grading system based on pathological features is explored. METHODS: Data from consecutive, primary, localised, INI1-deleted ES operated at three Italian sarcoma reference centres (1995-2015) were included. Centralised pathological review was perf...
4 CitationsSource
#1Sandro PasqualiH-Index: 28
#2Marco Bologna (Polytechnic University of Milan)H-Index: 6
Last. Alessandro GronchiH-Index: 88
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e23532Background: Prognosis of extremity soft tissue sarcomas (ESTS) and retroperitoneal sarcomas (RPS) is currently estimated on clinical-pathological features, as those incorporated in the Sarcul...