Gabriela Trevisan
Universidade Federal de Santa Maria
Internal medicineEndocrinologyNociceptionTransient receptor potential channelTRPV1ChemistryOxidative stressAntagonistInflammationNeuropathic painAllodyniaAgonistHyperalgesiaCapsaicinAnalgesicChronic painSciatic nerveAnesthesiaMedicinePharmacology
90Publications
28H-index
1,943Citations
Publications 95
Newest
Source
#1Leonardo Gomes Pereira (UFSM: Universidade Federal de Santa Maria)
#2Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 28
Last. Luis Guilherme Ramanzini (UFSM: Universidade Federal de Santa Maria)
view all 6 authors...
Multiple sclerosis (MS) is a chronic neurodegenerative, inflammatory and autoimmune disease characterised by the demyelination of the central nervous system. One of the main approaches to treating MS is the use of disease-modifying therapies (DMTs). Among the DMTs are interferons (IFNs), which are cytokines responsible for controlling the activity of the immune system, exerting immunomodulatory, antiviral, and antiproliferative activities. IFN-beta (IFN-β) is the first-choice drug used to treat ...
Source
#1Diéssica Padilha Dalenogare (UFSM: Universidade Federal de Santa Maria)H-Index: 7
Last. Gabriela TrevisanH-Index: 28
view all 13 authors...
ABSTRACT Primary headache conditions are frequently associated with multiple sclerosis (MS), but the mechanism that triggers or worsens headaches in patients with MS is poorly understood. We previously showed that the proalgesic transient receptor potential ankyrin 1 (TRPA1) mediates hind paw mechanical and cold allodynia in a relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE) model in mice. Here, we investigated the development of periorbital mechanical allodynia (PMA) in RR...
Source
#1Diéssica Padilha Dalenogare (UFSM: Universidade Federal de Santa Maria)H-Index: 7
#2Camila Duarte Ritter (UFSM: Universidade Federal de Santa Maria)H-Index: 10
Last. Juliano Ferreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 54
view all 0 authors...
Headaches are frequently described in progressive multiple sclerosis (PMS) patients, but their mechanism remains unknown. Transient receptor potential ankyrin 1 (TRPA1) was involved in neuropathic nociception in a model of PMS induced by experimental autoimmune encephalomyelitis (PMS-EAE), and TRPA1 activation causes periorbital and facial nociception. Thus, our purpose was to observe the development of periorbital mechanical allodynia (PMA) in a PMS-EAE model and evaluate the role of TRPA1 in p...
Source
#1Patricia Rodrigues (UFSM: Universidade Federal de Santa Maria)H-Index: 5
#2Guilherme Vargas Bochi (UFSM: Universidade Federal de Santa Maria)H-Index: 18
Last. Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 28
view all 3 authors...
Multiple sclerosis (MS) is an autoimmune-mediated disease that damages the central nervous system. MS pathophysiological features are not entirely understood, but the increase of reactive oxygen species (ROS) possibly causes myelin and oligodendrocyte degeneration. ROS-increased production generates new compounds through oxidative modifications, including advanced oxidative protein products (AOPPs). The AOPPs are oxidative stress biomarkers and inflammatory mediators commonly formed by hypochlor...
Source
#1Amanda Spring de Almeida (UFSM: Universidade Federal de Santa Maria)H-Index: 10
#2Laura de Barros Bernardes (UFSM: Universidade Federal de Santa Maria)H-Index: 2
Last. Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 28
view all 3 authors...
Abstract Chronic pain is a common symptom experienced during cancer progression. Additionally, some patients experience bone pain caused by cancer metastasis, which further complicates the prognosis. Cancer pain is often treated using opioid-based pharmacotherapy, but these drugs possess several adverse effects. Accordingly, new mechanisms for cancer pain management are being explored, including transient receptor potential channels (TRPs). TRP ion channels are expressed in several tissues and p...
Source
#1Diulle Spat Peres (UFSM: Universidade Federal de Santa Maria)H-Index: 2
#2Maria Carolina Theisen (UFSM: Universidade Federal de Santa Maria)H-Index: 2
Last. Tuane Bazanella Sampaio (UFSM: Universidade Federal de Santa Maria)H-Index: 12
view all 17 authors...
Abstract null null Progressive multiple sclerosis (PMS) is a neurological disease associated with the development of depression and anxiety, but treatments available are unsatisfactory. The transient receptor potential ankyrin 1 (TRPA1) is a cationic channel activated by reactive compounds, and the blockage of this receptor can reduce depression- and anxiety-like behaviors in naive mice. Thus, we investigated the role of TRPA1 in depression- and anxiety-like behaviors in a PMS model in mice. PMS...
Source
#1Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 28
#2Sara Marchesan Oliveira (UFSM: Universidade Federal de Santa Maria)H-Index: 28
Pain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmitting painful stimuli from the periphery until the dorsal horn of the spinal cord. Thus, blocking voltage-gated calcium channels (VGCCs) can effectively control pain refractory to treatments currently used in the clinic, such as cancer and neuropathi...
Source
#1Amanda Spring de Almeida (UFSM: Universidade Federal de Santa Maria)H-Index: 10
#2Gabriele Cheiran Pereira (UFSM: Universidade Federal de Santa Maria)H-Index: 4
Last. Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 28
view all 8 authors...
Abstract Aims Breast cancer-induced chronic pain is usually treated with opioids, but these compounds cause various adverse effects. Transient receptor potential ankyrin 1 (TRPA1) is involved in cancer pain; also, endogenous TRPA1 agonists are associated with cancer pain development. The aim of this study was to observe the antinociceptive effect of a repeated-dose TRPA1 antagonist administration and the production of endogenous TRPA1 agonists and TRPA1 expression in bone tissue in a model of br...
Source
#1Francesco De Logu (UniFI: University of Florence)H-Index: 17
#2Matilde Marini (UniFI: University of Florence)H-Index: 4
Last. Romina Nassini (UniFI: University of Florence)H-Index: 36
view all 12 authors...
Although macrophages (MΦ) are known to play a central role in neuropathic pain, their contribution to cancer pain has not been established. Here we report that depletion of sciatic nerve resident MΦs (rMΦ) in mice attenuates mechanical/cold hypersensitivity and spontaneous pain evoked by intraplantar injection of melanoma or lung carcinoma cells. MΦ-colony stimulating factor (M-CSF) was upregulated in the sciatic nerve trunk and mediated cancer-evoked pain via rMΦ expansion, transient receptor p...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.