Marco Fiocchetti
Roma Tre University
CancerGlobinDownregulation and upregulationEndocrinologyEstrogen receptor alphaChemistryApoptosisNeuroprotectionOxidative stressNeuroglobinEstrogenMitochondrionCytochrome cProgrammed cell deathCancer researchSignal transductionEstrogen receptorBiologyCell biologyCancer cell
Publications 31
#1Marco FiocchettiH-Index: 12
#2Patrizio CraccoH-Index: 1
Last. Maria Marino (Roma Tre University)H-Index: 43
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Abstract Dysfunctional mitochondria have severe consequences on cell functions including Reactive Oxygen Specie (ROS) generation, alteration of mitochondrial signaling, Ca2+ buffering, and activation of apoptotic pathway. These dysfunctions are closely linked with degenerative diseases including neurodegeneration. The discovery of neuroglobin (NGB) as an endogenous neuroprotective protein, which effects seem to depend on its mitochondrial localization, could drive new therapeutic strategies agai...
#1Claudia BusoneroH-Index: 8
#2Stefano LeoneH-Index: 21
Last. Filippo AcconciaH-Index: 30
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Estrogen receptor α expressing breast cancers (BC) are classically treated with endocrine therapy. Prolonged endocrine therapy often results in a metastatic disease (MBC), for which a standardized effective therapy is still lacking. Thus, new drugs are required for primary and metastatic BC treatment. Here, we report that the Food and Drug Administration (FDA)-approved drugs, ouabain and digoxin, induce ERα degradation and prevent proliferation in cells modeling primary and metastatic BC. Ouabai...
3 CitationsSource
#1Marco FiocchettiH-Index: 12
Last. Maria Marino (Roma Tre University)H-Index: 43
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1 CitationsSource
#1Emiliano MontalesiH-Index: 4
#2Manuela CipollettiH-Index: 8
Last. Maria Marino (Roma Tre University)H-Index: 43
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Although soy consumption is associated with breast cancer prevention, the low bioavailability and the extensive metabolism of soy-active components limit their clinical application. Here, the impact of daidzein (D) and its metabolites on estrogen-dependent anti-apoptotic pathway has been evaluated in breast cancer cells. In estrogen receptor α-positive breast cancer cells treated with D and its metabolites, single or in mixture, ERα activation and Neuroglobin (NGB) levels, an anti-apoptotic estr...
5 CitationsSource
#1Virginia Solar Fernandez (Roma Tre University)H-Index: 2
#1Virginia FernándezH-Index: 30
Last. Marco Fiocchetti (Roma Tre University)H-Index: 12
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Aims. Nuclear factor (erythroid-derived 2)-like-2 factor (NRF-2) is a transcription factor well known to provide an advantage for cancer growth and survival regulating the cellular redox pathway. I...
3 CitationsSource
Reactive oxygen species (ROS) result from intracellular aerobic metabolism and/or extracellular stimuli. Although endogenous antioxidant systems exquisitely balance ROS production, an excess of ROS production, commonly found in diverse human degenerative pathologies including cancer, gives rise to the oxidative stress. Increased oxidative stress in cancer is related to the sustained proliferation and metabolism of cancer cells. However, cancer cells show an intrinsic higher antioxidant capacity ...
6 CitationsSource
#1Manuela Cipolletti (Roma Tre University)H-Index: 8
#2Emiliano Montalesi (Roma Tre University)H-Index: 4
Last. Maria Marino (Roma Tre University)H-Index: 5
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: Neuroglobin (NGB), an antiapoptotic protein upregulated by 17β-estradiol (E2), is part of E2/estrogen receptor α (ERα) pathway pointed to preserve cancer cell survival in presence of microenvironmental stressors including chemotherapeutic drugs. Here, the possibility that resveratrol (Res), an anticancer plant polyphenol, could increase the susceptibility of breast cancer cells to paclitaxel (Pacl) by affecting E2/ERα/NGB pathway has been evaluated. In MCF-7 and T47D (ERα-positive), but not in...
7 CitationsSource
The potential “health benefits” of dietary polyphenols have been ascribed to their direct antioxidant activity and their impact on the regulation of cell and tissue redox balance. However, because of the relative poor bioavailability of many of these compounds, their effects could not be easily explained by the antioxidant action, which may occur only at high circulating and tissue concentrations. Therefore, many efforts have been put forward to clarify the molecular mechanisms underlining the b...
23 CitationsSource
#1Marco FiocchettiH-Index: 12
#2Manuela CipollettiH-Index: 8
Last. Maria MarinoH-Index: 43
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: Neuroglobin (NGB) is a relatively recent discovered monomeric heme-protein, which behave in neurons as a sensor of injuring stimuli including oxidative stress, hypoxia, and neurotoxicity. In addition, the anti-apoptotic activity of overexpressed NGB has been reported both in neurons and in cancer cell lines. We recently demonstrated that, NGB functions as a compensatory protein of the steroid hormone 17β-estradiol (E2) protecting cancer cells against the apoptotic death induced by oxidative st...
9 CitationsSource
#1Marco FiocchettiH-Index: 12
#2Manuela CipollettiH-Index: 8
Last. Maria Marino (Roma Tre University)H-Index: 43
view all 3 authors...
: Environmental factors or adverse growth conditions that may reduce cell function or viability are considered stress. The cell ability to sense and respond to environmental stresses determine its function and survival destiny. We recently defined Neuroglobin (NGB), a heme-protein, as a compensatory protein in the 17β-Estradiol (E2) anti-apoptotic activity and as a sensor of oxidative stress in both neurons and breast cancer cells. Here, the possibility that NGB levels could represent a pivotal ...
4 CitationsSource
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