Tim Rattay
University of Leicester
Quality of lifeGenome-wide association studyCancerInternal medicineSurgeryOncologyRadiogenomicsProspective cohort studyCohort studyChemotherapyBreast surgeryMastectomyAdjuvant therapyProstate cancerBreast reconstructionMammaplastyGynecologyToxicityUniversity hospitalRadiation therapyBreast cancerGeneral surgeryMedicineCohort
43Publications
9H-index
197Citations
Publications 41
Newest
#1Tim Rattay (University of Leicester)H-Index: 9
#2Kerstie Johnson (University of Leicester)H-Index: 2
Last. Christopher J. Talbot (University of Leicester)H-Index: 21
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BackgroundClinically significant side-effects from radiotherapy affect around a quarter of breast cancer patients and may have a considerable impact on breast cosmesis and quality of life. If patients at high risk of radiation toxicity could be identified at breast cancer diagnosis, this could be taken into account when discussing treatment options. The aim of this study was to develop a predictive model for acute skin toxicity in patients undergoing breast radiotherapy.MethodsUsing multivariate...
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#2A. AppanvelH-Index: 1
Last. Catharine M L WestH-Index: 77
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1 CitationsSource
#2Federica PaloriniH-Index: 11
#3M. De SantisH-Index: 15
Last. Laura LozzaH-Index: 18
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#1Tim RattayH-Index: 9
#2Kerstie JohnsonH-Index: 2
Last. Christopher J. TalbotH-Index: 21
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Clinically significant side-effects from radiotherapy affect around a quarter of breast cancer patients and may impact considerably on outcomes from treatment. An increasing number of replicated genetic associations for radiotherapy toxicity are being reported[1] ,[2] . The international REQUITE consortium aims to validate genetic markers and clinical factors implicated in radiotoxicity. The purpose of the REQUITE-AB project is to develop an integrated set of predictors for acute radiotherapy si...
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#1Tim RattayH-Index: 9
#2Kerstie JohnsonH-Index: 2
Last. Christopher J. TalbotH-Index: 21
view all 20 authors...
Clinically significant side-effects from radiotherapy affect around a quarter of breast cancer patients and may impact considerably on outcomes from treatment. An increasing number of replicated genetic associations for radiotherapy toxicity are being reported[1],[2]. The EU-funded REQUITE consortium aims to validate genetic markers and clinical factors implicated in radiotoxicity. The purpose of the REQUITE-AB project is to develop an integrated set of predictors for acute radiotherapy side-eff...
#1RV Dave (University Hospital of South Manchester NHS Foundation Trust)H-Index: 1
#2Rachel O'Connell (The Royal Marsden NHS Foundation Trust)H-Index: 9
Last. Chris HolcombeH-Index: 14
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Introduction Immediate breast reconstruction (IBR) is routinely offered to improve quality of life for women with breast cancer requiring a mastectomy, but there are concerns that more complex surgery may delay the delivery of adjuvant oncological treatments and compromise long-term oncological outcomes. High-quality evidence, however, is lacking. iBRA-2 is a national prospective multicentre cohort study that aims to investigate the effect of IBR on the delivery of adjuvant therapy. Methods and ...
7 CitationsSource
#1L. AshkenH-Index: 1
#2Charlotte Ives (Torbay Hospital)H-Index: 2
Last. E. BakerH-Index: 1
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Abstract Introduction Ductal carcinoma in situ (DCIS) accounts for approximately 10% of all newly-diagnosed breast cancers in the UK. The latest national guidelines were published in 2009 and may not reflect current best practice. We aimed to explore variation in the current management of DCIS to support the need for updated guidelines. Methods A national practice questionnaire was developed by the Mammary Fold Academic Committee (MFAC) focussing on the pre, intra and post-operative management o...
10 CitationsSource
#1Tim Rattay (University of Leicester)H-Index: 9
#2Kerstie Johnson (University of Leicester)H-Index: 2
Last. R. Paul Symonds (University of Leicester)H-Index: 14
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1 CitationsSource
#1Elizabeth A. BakerH-Index: 48
#1Elizabeth BakerH-Index: 1
Last. Shelley Potter (UoB: University of Bristol)H-Index: 17
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Abstract Introduction Wide local excision and adjuvant radiotherapy is the standard of care for early breast cancer. For large tumours, however, mastectomy is frequently recommended as conventional breast-conserving techniques often result in poor cosmetic outcomes. Therapeutic mammaplasty (TM) may extend the boundaries of breast-conserving surgery by combining breast reduction and mastopexy techniques with tumour excision, preserving a natural breast shape and avoiding the need for mastectomy. ...
10 CitationsSource
#1Petra Seibold (DKFZ: German Cancer Research Center)H-Index: 27
#2Sabine Behrens (DKFZ: German Cancer Research Center)H-Index: 17
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 124
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Purpose To identify single-nucleotide polymorphisms (SNPs) in oxidative stress–related genes associated with risk of late toxicities in breast cancer patients receiving radiation therapy. Methods and Materials Using a 2-stage design, 305 SNPs in 59 candidate genes were investigated in the discovery phase in 753 breast cancer patients from 2 prospective cohorts from Germany. The 10 most promising SNPs in 4 genes were evaluated in the replication phase in up to 1883 breast cancer patients from 6 c...
46 CitationsSource