Tessa Crompton
UCL Institute of Child Health
Internal medicineEndocrinologyAntigenCellular differentiationMolecular biologyCD8T-cell receptorImmunologyT cellSonic hedgehogHedgehogThymocytePopulationCancer researchSignal transductionTranscription factorBiologyHedgehog signaling pathwayImmune systemCell biology
89Publications
32H-index
5,552Citations
Publications 90
Newest
#1Ching-In Lau (ICH: UCL Institute of Child Health)H-Index: 9
#2Diana C. Yánez (ICH: UCL Institute of Child Health)H-Index: 6
Last. Tessa Crompton (ICH: UCL Institute of Child Health)H-Index: 32
view all 5 authors...
Epithelial barrier tissues such as the skin and airway form an essential interface between the mammalian host and its external environment. These physical barriers are crucial to prevent damage and disease from environmental insults and allergens. Failure to maintain barrier function against such risks can lead to severe inflammatory disorders, including atopic dermatitis and asthma. Here, we discuss the role of the morphogen Sonic Hedgehog in postnatal skin and lung and the impact of Shh signal...
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#1Diana C. Yánez (ICH: UCL Institute of Child Health)H-Index: 6
#2Eleftheria Papaioannou (ICH: UCL Institute of Child Health)H-Index: 5
Last. Tessa Crompton (ICH: UCL Institute of Child Health)H-Index: 32
view all 7 authors...
Allergic asthma is a common inflammatory disease of the lungs and airways in which Th2 immune responses and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models, human tissues and genome wide association have indicated that Sonic Hedgehog (Shh) and the Hedgehog (Hh) signalling pathway are involved in allergic asthma and that Shh is upregulated in the lung on disease induction. We used a papain-induced mouse model of allergic airways i...
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#1Ching-In Lau (ICH: UCL Institute of Child Health)H-Index: 9
#2Jasmine Rowell (ICH: UCL Institute of Child Health)H-Index: 3
Last. Tessa Crompton (ICH: UCL Institute of Child Health)H-Index: 32
view all 7 authors...
During positive selection at the transition from CD4+CD8+ double-positive (DP) to single positive (SP) thymocyte, TCR signalling results in appropriate MHC-restriction and signals for survival and progression. We show that the pioneer transcription factors Foxa1 and Foxa2 are required to regulate RNA splicing during positive selection. Foxa1 and Foxa2 had overlapping/compensatory roles. Conditional deletion of both Foxa1 and Foxa2 from DP thymocytes reduced positive selection and development of ...
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#1Konstantinos Mengrelis (Medical University of Vienna)H-Index: 5
#2Filip Kucera (GOSH: Great Ormond Street Hospital)H-Index: 3
Last. E. Graham Davies (GOSH: Great Ormond Street Hospital)H-Index: 20
view all 12 authors...
Paediatric heart transplantation recipients suffer an increased incidence of infectious, autoimmune and allergic problems. The relative roles of thymus excision and immunosuppressive treatments in contributing to these sequelae are not clear. We compared the immunological phenotypes of 25 heart transplant recipients (Tx), 10 children who underwent thymus excision during non-transplantation cardiac surgery (TE) and 25 age range-matched controls, in two age bands: 1-9 and 10-16 years. Significant ...
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#1Diana C. Yánez (USFQ: Universidad San Francisco de Quito)H-Index: 6
#2Susan Ross (ICH: UCL Institute of Child Health)H-Index: 14
Last. Tessa CromptonH-Index: 32
view all 3 authors...
Interferon-inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1-IFITM3), osteoblast function and bone mineralization (IFITM5) and immune functions (IFITM1-3, IFITM6). IFITM1-3 are expressed by T cells and recent experiments ha...
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#1Anisha SolankiH-Index: 9
#2Diana C. YánezH-Index: 6
Last. Tessa CromptonH-Index: 32
view all 8 authors...
Pre-TCR signal transduction is required for developing thymocytes to differentiate from CD4-CD8- double negative (DN) to CD4+CD8+ double positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6 and that Bcl6 is required for differentiation to DP. Condition...
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#1Eleftheria Papaioannou (UCL: University College London)H-Index: 5
#2Diana C. Yánez (UCL: University College London)H-Index: 6
Last. Tessa CromptonH-Index: 32
view all 11 authors...
: Hedgehog (Hh) proteins regulate development and tissue homeostasis, but their role in atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin, and Hh pathway action in skin T cells were increased. Shh signaling reduced AD pathology and the levels of Shh expression determined disease severity. Hh-mediated transcription in skin T cells in AD-induced mice increased Treg populations and their suppressive function through increased act...
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#1Diana C. Yánez (USFQ: Universidad San Francisco de Quito)H-Index: 6
#2Ching-In LauH-Index: 9
Last. Tessa CromptonH-Index: 32
view all 6 authors...
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#2Ching-In LauH-Index: 9
Last. Tessa CromptonH-Index: 32
view all 9 authors...
Here we investigate the function of Hedgehog (Hh) signalling in thymic  T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signalling promotes  T-cell development in the thymus and influences  T-cell effector subset distribution. Hh-mediated transcription in thymic  cells increased  T-cell number, and promoted their maturation and increased the NKT subset, whereas inhibition of Hh-mediated transcription reduced the thymic  T-cell population and incr...
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#1Sadia Saeed (Lond: University of London)H-Index: 7
#2Ching-In Lau (ICH: UCL Institute of Child Health)H-Index: 9
Last. Johannes T. Dessens (Lond: University of London)H-Index: 26
view all 5 authors...
Abstract Malaria parasite oocysts generate sporozoites by a process termed sporogony. Essential for successful sporogony of Plasmodium berghei in Anopheles stephensi mosquitoes is a complex of six LCCL lectin domain adhesive-like proteins (LAPs). LAP null mutant oocysts undergo growth and mitosis but fail to form sporozoites. At a cytological level, LAP null mutant oocyst development is indistinguishable from its wildtype counterparts for the first week, supporting the hypothesis that LAP null m...
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