Andreas Gießl
University of Erlangen-Nuremberg
CiliumOphthalmologyBasal bodyChromosomal translocationHeterotrimeric G proteinTransducinCompartment (development)ChemistryRhodopsinImmunologyMicrotubuleRetinaCentrinPeripherin 2PCNTRetinalPhotoreceptor cellRetinitis pigmentosaCiliopathiesIntraflagellar transportMutationGene isoformGeneticsSignal transductionMedicineG proteinBiologyCell biology
42Publications
12H-index
841Citations
Publications 42
Newest
#1Naresh Polisetti (University of Freiburg)H-Index: 11
#2Andreas Gießl (FAU: University of Erlangen-Nuremberg)H-Index: 12
Last. Ursula Schlötzer-Schrehardt (FAU: University of Erlangen-Nuremberg)H-Index: 76
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PURPOSE Limbal melanocytes (LMel) represent essential components of the corneal epithelial stem cell niche and are known to protect limbal epithelial stem/progenitor cells (LEPCs) from UV damage by transfer of melanosomes. Here, we explored additional functional roles for LMel in niche homeostasis, immune regulation and angiostasis. METHODS Human corneoscleral tissues were morphologically analyzed in normal, inflammatory and wound healing conditions. The effects of LMel on LEPCs were analyzed in...
2 CitationsSource
#1Uwe Thorsten Lux (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2Johanna Ehrenberg (FAU: University of Erlangen-Nuremberg)
Last. Johann Helmut Brandstätter (FAU: University of Erlangen-Nuremberg)H-Index: 52
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Complexins (Cplxs) 1 to 4 are components of the presynaptic compartment of chemical synapses where they regulate important steps in synaptic vesicle exocytosis. In the retina, all four Cplxs are present, and while we know a lot about Cplxs 3 and 4, little is known about Cplxs 1 and 2. Here, we performed in situ hybridization experiments and bioinformatics and exploited Cplx 1 and Cplx 2 single-knockout mice combined with immunocytochemistry and light microscopy to characterize in detail the cell...
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#1Bettina HohbergerH-Index: 9
#2Marion Ganslmayer (FAU: University of Erlangen-Nuremberg)H-Index: 12
Last. Julia FürstH-Index: 3
view all 19 authors...
1 CitationsSource
#1Bettina HohbergerH-Index: 9
#2Thomas HarrerH-Index: 37
Last. Julia SchottenhammlH-Index: 7
view all 21 authors...
Clinical features of Corona Virus Disease 2019 (COVID-19) are caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute infection management is a substantial health care issue, and the development of a Long-Covid syndrome (LCS) is extremely challenging for patients and physicians. It is associated with a variety of characteristics as e.g. impaired capillary microcirculation, chronic fatigue syndrome (CFS) and functional autoantibodies targeting G-protein coupled receptors...
Abstract null null Purpose null Abnormalities in the limbal niche microenvironment have been suggested to be causally involved in aniridia-associated keratopathy (AAK), but histological analyses on the limbal structure and composition in AAK are lacking. Here, we investigated morphologic and molecular alterations of the limbal epithelial stem cell niche in human congenital aniridia. null null null Methods null The blind, buphthalmic and painful left eye of a 16-year old girl with congenital anir...
1 CitationsSource
#1Darja Andreev (FAU: University of Erlangen-Nuremberg)H-Index: 6
#2Mengdan Liu (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Aline Bozec (FAU: University of Erlangen-Nuremberg)H-Index: 27
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Objectives Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils. Therefore, we investigated whether asthma, a paradigm eosinophilic disease, can elicit resolution of chronic arthritis. Methods Ovalbumin-triggered eosinophilic asthma was combine...
13 CitationsSource
#1Ursula Schlötzer-Schrehardt (FAU: University of Erlangen-Nuremberg)H-Index: 76
#2Matthias Zenkel (FAU: University of Erlangen-Nuremberg)H-Index: 23
Last. Friedrich E. Kruse (FAU: University of Erlangen-Nuremberg)H-Index: 67
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Abstract Purpose Rho-associated kinase (ROCK) inhibitors have been successfully used as a rescue strategy in eyes that failed to clear after descemetorhexis without endothelial graft for treatment of Fuchs endothelial corneal dystrophy (FECD). The functional mechanisms by which ROCK inhibitors modulate corneal endothelial cell regeneration in FECD patients have, however, not been clarified. Here, we analyzed the effect of the ROCK inhibitor ripasudil on corneal endothelial cells of FECD patients...
3 CitationsSource
#1Naresh Polisetti (University of Freiburg)H-Index: 11
#2Andreas Gießl (FAU: University of Erlangen-Nuremberg)H-Index: 12
Last. Ursula Schlötzer-Schrehardt (FAU: University of Erlangen-Nuremberg)H-Index: 76
view all 6 authors...
Limbal melanocytes, located in the basal epithelial layer of the corneoscleral limbus, represent essential components of the corneal epithelial stem cell niche, but, due to difficulties in their isolation and cultivation, their biological roles and potential for stem cell-based tissue engineering approaches have not been comprehensively studied. Here, we established a protocol for the efficient isolation and cultivation of pure populations of human limbal melanocytes, which could be expanded at ...
7 CitationsSource
#1Andreas Gießl (FAU: University of Erlangen-Nuremberg)H-Index: 12
#2Naresh Polisetti (University of Freiburg)H-Index: 11
Last. Ursula Schlötzer-Schrehardt (FAU: University of Erlangen-Nuremberg)H-Index: 76
view all 5 authors...
#1Andreas Gießl (FAU: University of Erlangen-Nuremberg)H-Index: 12
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