Shigeki Yagyu
Kyoto Prefectural University of Medicine
Cell cycle checkpointFusion geneCancerInternal medicinePathologyMolecular biologyPAX3ChemistryApoptosisDNA methylationImmunologySurvival rateNeuroblastomaRhabdomyosarcomaCell cycleSuicide geneCancer researchDNACell growthMedicineCell cultureBiology
48Publications
14H-index
874Citations
Publications 50
Newest
#1Takuyo Kanayama (Kyoto Prefectural University of Medicine)H-Index: 2
#2Mitsuru Miyachi (Kyoto Prefectural University of Medicine)H-Index: 11
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 8 authors...
B7-H3 (also known as CD276) is associated with aggressive characteristics in various cancers. Meanwhile, in alveolar rhabdomyosarcoma (ARMS), PAX3-FOXO1 fusion protein is associated with increased aggressiveness and poor prognosis. In the present study, we explored the relationship between PAX3-FOXO1 and B7-H3 and the biological roles of B7-H3 in ARMS. Quantitative real time PCR and flow cytometry revealed that PAX3-FOXO1 knockdown downregulated B7-H3 expression in all the selected cell lines (R...
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#1Satoshi Obu (Kyoto University)
#2Katsutsugu Umeda (Kyoto University)H-Index: 15
Last. Itaru Kato (Kyoto University)H-Index: 12
view all 27 authors...
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to arise from neural crest-derived immature cells. The prognosis of patients with high-risk or recurrent/refractory neuroblastoma remains quite poor despite intensive multimodality therapy; therefore, novel therapeutic interventions are required. We examined the expression of a cell adhesion molecule CD146 (melanoma cell adhesion molecule [MCAM]) by neuroblastoma cell lines and in clinical samples and investigated t...
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#1Hiroshi Kubo (Kyoto Prefectural University of Medicine)H-Index: 1
#2Shigeki Yagyu (Kyoto Prefectural University of Medicine)H-Index: 14
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
Abstract Ephrin type-B receptor 4 (EPHB4), expressed in tumors including rhabdomyosarcoma, is a suitable target for chimeric antigen receptor (CAR)-T cells. Ligand independent activation of EPHB4 causes cell proliferation and malignant transformation in rhabdomyosarcoma, whereas ligand-dependent stimulation of EPHB4 induces apoptosis in rhabdomyosarcoma. Therefore, we hypothesized that ligand-based EPHB4-specific CAR-T cells may kill rhabdomyosarcoma cells without stimulating downstream cell pro...
2 CitationsSource
#1Tamaki Morisako (Kyoto Prefectural University of Medicine)
#2Daisuke Umebayashi (Kyoto Prefectural University of Medicine)H-Index: 1
Last. Naoya Hashimoto (Kyoto Prefectural University of Medicine)H-Index: 30
view all 13 authors...
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#1Takumi Yamanaka (Kyoto Prefectural University of Medicine)H-Index: 3
#2Yoshinobu Takahashi (Kyoto Prefectural University of Medicine)H-Index: 8
Last. Naoya Hashimoto (Kyoto Prefectural University of Medicine)H-Index: 30
view all 13 authors...
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#1Yohei Sugimoto (Kyoto Prefectural University of Medicine)H-Index: 1
#2Yoshiki Katsumi (Kyoto Prefectural University of Medicine)H-Index: 8
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 14 authors...
Rhabdoid tumor is an aggressive, early childhood tumor. Biallelic inactivation of the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)/integrase interactor 1 (INI1) gene is the only common genetic feature in rhabdoid tumors. Loss of SMARCB1 function results in downregulation of several tumor suppressor genes including p16, p21, and NOXA. The novel histone deacetylase inhibitor, OBP-801, induces p21 and has shown efficacy against various canc...
1 CitationsSource
#1Kazutaka Ouchi (Kyoto Prefectural University of Medicine)H-Index: 6
#2Mitsuru Miyachi (Kyoto Prefectural University of Medicine)H-Index: 11
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 8 authors...
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. There are two subtypes, fusion gene-positive RMS (FP-RMS) and fusion gene-negative RMS (FN-RMS), depending on the presence of a fusion gene, either PAX3-FOXO1 or PAX7-FOXO1. These fusion genes are thought to be oncogenic drivers of FP-RMS. By contrast, the underlying mechanism of FN-RMS has not been thoroughly investigated. It has recently been shown that HMGA2 is specifically positive in pathological tissue from FN-RMS, bu...
2 CitationsSource
#5Kazuaki Tokiwa (Kyoto Prefectural University of Medicine)H-Index: 18
#6Hideto TakahashiH-Index: 26
Last. Tatsuro Tajiri (Kyoto Prefectural University of Medicine)H-Index: 20
view all 11 authors...
BACKGROUND: Few clinical trials have been reported for patients with intermediate-risk neuroblastoma because of the scarcity of the disease and the variety of clinical and biological characteristics. A multidisciplinary treatment that consists of multidrug chemotherapy and surgery is expected to lead to a good prognosis with few complications. Therefore, a clinical trial for patients with intermediate-risk tumors was designed to establish a standard treatment that reduces complications and achie...
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#1Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
#2Akihiro YonedaH-Index: 22
Last. Tatsuro Tajiri (Kyoto Prefectural University of Medicine)H-Index: 20
view all 13 authors...
BACKGROUND: The present study sought to reduce the incidence of treatment complications of low-risk neuroblastoma by using image-defined risk factors (IDRFs) to inform the timing of surgical resection. PROCEDURES: Eligible patients included children (<18 years of age) with stage 1 or 2 disease, children (<365 days of age) with stage 3 disease, and infants with stage 4S disease. In IDRF-negative cases, treatment was completed with surgical resection alone. In IDRF-positive cases, the timing of su...
4 CitationsSource
#1Yuki Naito (Kyoto Prefectural University of Medicine)H-Index: 1
#2Jun Mori (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 10 authors...
: A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and lower lip. Blood examination revealed hypothyrotropinemia, and ultrasonography results revealed multiple thyroid nodules. She was diagnosed with Carney complex (CNC). Her pituita...
2 CitationsSource