Amir-Hadi Maghzi
Brigham and Women's Hospital
EpidemiologyInternal medicineSurgeryPathologyMagnetic resonance imagingCase-control studyOdds ratioNeurosciencePhysical therapyPediatricsImmunologyYoung adultVirusPlaceboDiseaseMultiple sclerosisExpanded Disability Status ScaleAtrophyPopulationIncidence (epidemiology)Risk factorCentral nervous systemMedicine
Publications 75
#1Laura M. CoxH-Index: 25
#2Amir-Hadi MaghziH-Index: 20
Last. Howard L. WeinerH-Index: 164
view all 18 authors...
OBJECTIVE Investigate the gut microbiome in progressive multiple sclerosis (MS) and how it relates to clinical disease. METHODS We sequenced the microbiota from healthy controls, relapsing remitting MS (RRMS), and progressive MS patients and correlated the levels of bacteria with clinical features of disease, including EDSS, quality of life, and brain MRI lesions/atrophy. We colonized mice with MS-derived Akkermansia and induced experimental autoimmune encephalomyelitis. RESULTS Microbiota β-div...
4 CitationsSource
OBJECTIVE We systematically reviewed the literature on COVID-19 in patients with multiple sclerosis (MS). METHODS We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Google Scholar, and World Health Organization database from December 1, 2019, to December 18, 2020. Three conference abstract databases were also searched. We included any types of studies that reported characteristics of patients with MS with COVID-19. RESULTS From an initial 2,679 publications and 3,138 conference abstract...
9 CitationsSource
#1Amir-Hadi Maghzi (Brigham and Women's Hospital)H-Index: 20
#2Howard L. Weiner (Brigham and Women's Hospital)H-Index: 164
Summary The microbiome plays an important role in multiple sclerosis. In a recent issue of Nature, Miyauchi et al. report that gut microbial molecular mimicry in concert with gut microbes that enhance Th17 cells act synergistically to worsen CNS autoimmunity.
#1Mahdi Barzegar (IUMS: Isfahan University of Medical Sciences)H-Index: 6
#2Omid Mirmosayyeb (IUMS: Isfahan University of Medical Sciences)H-Index: 10
Last. Vahid Shaygannejad (IUMS: Isfahan University of Medical Sciences)H-Index: 23
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In December 2019, a novel coronavirus causing an infectious respiratory disease (COVID-19) was identified, which since then has developed into a pandemic with higher rates of mortality in older individuals and those with underlying medical conditions.1 Multiple sclerosis (MS) is an immune-mediated neurologic disease which requires long-term treatment with immunotherapies that have been shown to increase the risk of infections.2 As a result, there is significant anxiety among patients and neurolo...
51 CitationsSource
#1Amir-Hadi Maghzi (Brigham and Women's Hospital)H-Index: 20
#2Nancy L. Sicotte (Cedars-Sinai Medical Center)H-Index: 38
Last. Emmanuelle Waubant (UCSF: University of California, San Francisco)H-Index: 71
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#1Mahsa Ghajarzadeh (Tehran University of Medical Sciences)H-Index: 16
#2Omid Mirmosayyeb (IUMS: Isfahan University of Medical Sciences)H-Index: 10
Last. Amir-Hadi Maghzi (Brigham and Women's Hospital)H-Index: 20
view all 7 authors...
26 CitationsSource
#1Amir-Hadi Maghzi (Harvard University)H-Index: 20
#2Maria K. Houtchens (Harvard University)H-Index: 20
Last. Rohit Bakshi (Harvard University)H-Index: 79
view all 15 authors...
The outbreak of a severe acute respiratory syndrome caused by a novel coronavirus (COVID-19), has raised health concerns for patients with multiple sclerosis (MS) who are commonly on long-term immunotherapies. Managing MS during the pandemic remains challenging with little published experience and no evidence-based guidelines. We present five teriflunomide-treated patients with MS who subsequently developed active COVID-19 infection. The patients continued teriflunomide therapy and had self-limi...
35 CitationsSource
#1Laura M. Cox (Brigham and Women's Hospital)H-Index: 25
#2Hadi Abou-El-Hassan (Brigham and Women's Hospital)H-Index: 8
Last. Howard L. Weiner (Brigham and Women's Hospital)H-Index: 164
view all 5 authors...
Abstract Several neurologic diseases exhibit different prevalence and severity in males and females, highlighting the importance of understanding the influence of biologic sex and gender. Beyond host-intrinsic differences in neurologic development and homeostasis, evidence is now emerging that the microbiota is an important environmental factor that may account for differences between men and women in neurologic disease. The gut microbiota is composed of trillions of bacteria, archaea, viruses, ...
6 CitationsSource
#1Rafael M. Rezende (Brigham and Women's Hospital)H-Index: 17
#2Brenda Naemi Nakagaki (UFMG: Universidade Federal de Minas Gerais)H-Index: 7
Last. Howard L. WeinerH-Index: 164
view all 12 authors...
: Oral tolerance is defined as the specific suppression of cellular and/or humoral immune responses to an Ag by prior administration of the Ag through the oral route. Although the investigation of oral tolerance has classically involved Ag feeding, we have found that oral administration of anti-CD3 mAb induced tolerance through regulatory T (Treg) cell generation. However, the mechanisms underlying this effect remain unknown. In this study, we show that conventional but not plasmacytoid dendriti...
8 CitationsSource
#1Amir-Hadi Maghzi (Cedars-Sinai Medical Center)H-Index: 20
#2Supreet K. Sahai (Cedars-Sinai Medical Center)H-Index: 3
Last. Robert H. Baloh (Cedars-Sinai Medical Center)H-Index: 57
view all 4 authors...
Palatal tremor, also known as palatal myoclonus, is a sign caused by a lesion to the Guillain-Mollaret triangle. In some cases, imaging may also reveal hypertrophic olivary degeneration, which is due to trans-synaptic degeneration and gliosis of the inferior olivary nucleus. The underlying etiology is commonly due to unilateral involvement of the central tegmental tract due to ischemic, neoplastic, demyelinating, traumatic, inflammatory, and rarely neurodegenerative processes such as progressive...
3 CitationsSource