Joshua A. Lile
University of Kentucky
PsychiatryPsychologyPlaceboDextroamphetamineCannabisMethylphenidateAmphetamineSelf-administrationDrugMethamphetamineStimulantSubstance abuseAnesthesiaAddictionPharmacotherapyReinforcementClinical psychologyMedicineNasal administrationPharmacology
Publications 105
Recent advances in diagnostic research identified that individuals with higher impulsivity and sensation-seeking scores tend to report more positive subjective responses to stimulant drugs such as amphetamine. The current exploratory study hypothesized that differences in underlying mesocorticolimbic circuitry may mediate the relationship between personality and responses to stimulants due to its previously established implication in reward processes as well as the overlap between its dopaminerg...
#1Mohit Kumar (UK: University of Kentucky)H-Index: 8
#1Mohit Kumar (UK: University of Kentucky)H-Index: 1
Last. Jill R. Turner (UK: University of Kentucky)H-Index: 2
view all 7 authors...
Opioid use disorder is a leading cause of morbidity and mortality in the United States. Increasing pre-clinical and clinical evidence demonstrates sex differences in opioid use and dependence. However, the underlying molecular mechanisms contributing to these effects, including neuroinflammation, are still obscure. Therefore, in this study, we investigated the effect of oxycodone exposure and withdrawal on sex- and region-specific neuroimmune response. Real-time PCR and multiplex cytokine array ...
1 CitationsSource
#1Craig R. RushH-Index: 51
#2William W. StoopsH-Index: 33
Last. Abner O. RayapatiH-Index: 6
view all 8 authors...
Abstract Rationale Cocaine use disorder is an unrelenting public health concern. Despite nearly four decades of research, an FDA approved medication is not yet available. Objectives The objective of this human laboratory study was to demonstrate the initial efficacy, safety and tolerability of topiramate-phentermine combinations for cocaine use disorder. Methods Thirty-one (31) participants with cocaine use disorder completed this mixed-model inpatient laboratory study. Participants were maintai...
1 CitationsSource
#1Joseph L. Alcorn (UK: University of Kentucky)H-Index: 25
#2Justin C. Strickland (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
Last. Craig R. Rush (University of Kentucky College of Arts and Sciences)H-Index: 51
view all 5 authors...
Abstract Mechanistic research on behavioral processes underlying substance use disorder might help identify novel targets for interventions development. Drug-related attentional bias and response inhibition deficits have received a great deal of consideration in substance use research, broadly, and cocaine use research, specifically. Studies investigating pharmacological mechanisms that may ameliorate, or further impair, these behaviors relevant to cocaine use are relatively lacking. This study ...
#1William W. Stoops (University of Kentucky College of Arts and Sciences)H-Index: 33
#1William W. Stoops (University of Kentucky College of Arts and Sciences)H-Index: 3
Last. Craig R. Rush (University of Kentucky College of Arts and Sciences)H-Index: 2
view all 6 authors...
RATIONALE Glutamate systems play an important role in the abuse related effects of alcohol. n-Acetylcysteine, a drug that promotes glutamate homeostasis, attenuates a range of alcohol effects in preclinical models. OBJECTIVES This human laboratory study determined the influence of n-acetylcysteine maintenance on alcohol self-administration using a model predictive of treatment effectiveness, along with the subjective, performance and physiological effects of alcohol. We hypothesized that n-acety...
2 CitationsSource
#1Thomas P. Shellenberg (UK: University of Kentucky)H-Index: 1
#2William W. Stoops (UK: University of Kentucky)H-Index: 33
Last. Craig R. Rush (UK: University of Kentucky)H-Index: 51
view all 4 authors...
Methylphenidate remains a first-line medication for treating ADHD in children and adults. However, its behavioral pharmacological similarities to methamphetamine and cocaine have historically creat...
3 CitationsSource
#1Mallory Loflin (UCSD: University of California, San Diego)H-Index: 9
#2Brian D. Kiluk (Yale University)H-Index: 21
Last. Eric C. Strain (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 57
view all 23 authors...
There is considerable variability in the use of outcome measures in clinical trials for cannabis use disorder (CUD), and a lack of consensus regarding optimal outcomes may have hindered development and approval of new pharmacotherapies. The goal of this paper is to summarize an evaluation of assessment measures and clinical endpoints for CUD clinical trials, and propose a research agenda and priorities to improve CUD clinical outcome assessments. The primary recommendation is that sustained abst...
10 CitationsSource
#1Joshua A. Lile (UK: University of Kentucky)H-Index: 23
#2Amy R Johnson (MCV: VCU Medical Center)H-Index: 1
Last. S. Stevens Negus (MCV: VCU Medical Center)H-Index: 10
view all 11 authors...
: Drug self-administration procedures are the gold standard for laboratory research to study mechanisms of drug use disorders and evaluate candidate medications. However, preclinical-to-clinical translation has been hampered by a lack of coordination. To address this limitation, we previously developed homologous intravenous (IV) cocaine choice self-administration procedures in rhesus monkeys and humans, and then demonstrated their functional equivalence. The present studies sought to determine ...
12 CitationsSource
#1Justin C. Strickland (University of Kentucky College of Arts and Sciences)H-Index: 17
#2Ethan M. Campbell (UK: University of Kentucky)H-Index: 2
Last. William W. StoopsH-Index: 33
view all 4 authors...
BACKGROUND ANDAIMS: The commodity purchase task is a simulated demand procedure that is easy and quick to complete (< 5 minutes) as well as adaptable for remote delivery and use with varied study populations. The purpose of this meta-analysis was to synthesize research using the commodity purchase task with illicit substances to evaluate the magnitude of omnibus effects sizes and moderators of the correlation of demand indices with quantity-frequency (QF) and severity measures. DESIGN: Random-ef...
14 CitationsSource
#1Justin C. Strickland (University of Kentucky College of Arts and Sciences)H-Index: 17
#2Joshua A. Lile (University of Kentucky College of Arts and Sciences)H-Index: 3
Last. William W. Stoops (University of Kentucky College of Arts and Sciences)H-Index: 33
view all 3 authors...
Abstract Background Drug-related cues play a critical role in the development and persistence of substance use disorder. Few human laboratory studies have evaluated how these cues contribute to decisions between concurrently presented reinforcers, and none have examined the specific role of cannabis cues. This study evaluated the contribution of cannabis-related cues to concurrent monetary reinforcer choice in humans. Methods Participants with a cannabis use history (i.e., use in the past two we...
3 CitationsSource