Robert J. de Knegt
Erasmus University Rotterdam
Internal medicineVirologyImmunologyHepatitis C virusHepatitis CPegylated interferonViral hepatitisLiver diseaseCirrhosisHepatitis BLiver transplantationRibavirinFibrosisPopulationChronic hepatitisHepatologyMedicineBiologyImmune systemGastroenterology
Publications 147
#1Pere GinèsH-Index: 117
#2Laurent Castera (University of Paris)H-Index: 63
Last. Llorenç CaballeríaH-Index: 26
view all 29 authors...
Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD), although chronic hepatitis B and C infections are still major etiological factors in some areas of the world. Recent studies have shown that liver fibrosis can be assessed with relatively high accuracy non-invasively by serological tests, transient ela...
#1Fang Zhu (Erasmus University Medical Center)
#2Banafsheh Arshi (Erasmus University Medical Center)H-Index: 3
Last. Maryam Kavousi (Erasmus University Medical Center)H-Index: 62
view all 5 authors...
To establish age- and sex-specific distribution of the infrarenal abdominal aortic diameters (IAD) among non-aneurysmal elderly population and to investigate the associations between traditional cardiovascular risk factors and IAD in men and women. We included 4032 participants (mean age 67.2 years; 60.4% women) from the population-based Rotterdam Study, free of cardiovascular disease, who underwent IAD ultrasound assessment between 2009-2014. Linear regression analysis was used to identify dete...
#1Hannah S.J. Choi (U of T: University of Toronto)H-Index: 1
#2Margo J.H. van Campenhout (Erasmus University Medical Center)H-Index: 6
Last. Harry L.A. Janssen (UHN: University Health Network)H-Index: 88
view all 8 authors...
Abstract Background and Aims Interferon-alpha (IFN-α) treatment for chronic hepatitis B (CHB) virus infection is finite and leads to relatively higher functional cure rates (HBsAg loss) than nucleo(s)tide analogue (NA) therapy. Effects of pegylated (PEG)/conventional IFN-α treatment on clinical outcomes were evaluated in an ultra long-term follow-up of CHB patients. Methods HBeAg-positive patients treated with (PEG)IFN-α at a tertiary referral centre between 1977-2014 were included. We reviewed ...
#1Laurens A. van Kleef (EUR: Erasmus University Rotterdam)
#2Ibrahim Ayada (EUR: Erasmus University Rotterdam)
Last. Robert J. de Knegt (EUR: Erasmus University Rotterdam)H-Index: 34
view all 5 authors...
BACKGROUND & AIMS Recently metabolic dysfunction associated fatty liver disease (MAFLD) has been introduced and was defined as hepatic steatosis with either overweight, diabetes and/or a combination of other metabolic risk factors. We investigated the application of the novel MAFLD criteria as compared to non-alcoholic fatty liver disease (NAFLD). APPROACH & RESULTS We performed a cross-sectional analysis within The Rotterdam Study, a large prospective population-based cohort. Participants who a...
#1Laurens A. van Kleef (EUR: Erasmus University Rotterdam)
#2Milan J. Sonneveld (EUR: Erasmus University Rotterdam)H-Index: 19
Last. Robert J. de Knegt (EUR: Erasmus University Rotterdam)H-Index: 34
view all 4 authors...
#1Laurens A. van Kleef (EUR: Erasmus University Rotterdam)
#2Hannah S.J. Choi (UHN: University Health Network)H-Index: 1
Last. Milan J. Sonneveld (EUR: Erasmus University Rotterdam)H-Index: 19
view all 9 authors...
#1Boris J. B. Beudeker (EUR: Erasmus University Rotterdam)H-Index: 3
#2Jolanda J.C. Voermans (EUR: Erasmus University Rotterdam)H-Index: 9
Last. Annemiek A. van der Eijk (EUR: Erasmus University Rotterdam)H-Index: 29
view all 7 authors...
Abstract null null Background & aims null Hepatitis D virus infection (HDV) is considered the most severe form of viral hepatitis. In this study, we aimed to evaluate the prevalence of HDV infection in a tertiary center of a large, multi-ethnic city in the Netherlands. Moreover, we validate the reliability of a novel anti-HDV CLIA assay. null null null Methods null All HBsAg-positive patients visiting the outpatient clinic between 2017 and 2019 were tested for HDV serology. Seropositive serum sa...
#1Aafke A. Duizendstra (EUR: Erasmus University Rotterdam)
#2Robert J. de Knegt (EUR: Erasmus University Rotterdam)H-Index: 34
Last. Nicolle H.R. Litjens (EUR: Erasmus University Rotterdam)H-Index: 27
view all 14 authors...
Spontaneous operational tolerance to the allograft develops in a proportion of liver transplant (LTx) recipients weaned off immunosuppressive drugs (IS). Several studies have investigated whether peripheral blood circulating T-cells could play a role in the development or identify operational tolerance, but never characterized alloreactive T-cells in detail due to the lack of a marker for these T-cells. In this study we comprehensively investigated phenotypic and functional characteristics of al...
Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption ...
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