Luisa Salvatori
Sapienza University of Rome
EndocrinologyPathologyCellMolecular biologyStromal cellReceptorAdipose tissueProstateInflammationAndrogenLNCaPProstate cancerStem cellCancer researchAndrogen receptorMedicineCell cultureEstrogen receptorBiologyCell biology
Publications 30
#1Enrico Lattuada (Sapienza University of Rome)H-Index: 3
#2Manuela Leo (Sapienza University of Rome)H-Index: 4
Last. Patrizia Filetici (Sapienza University of Rome)H-Index: 21
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2 CitationsSource
#1Annarita Favia (National Research Council)H-Index: 8
#2Luisa Salvatori (National Research Council)H-Index: 17
Last. Barbara Illi (National Research Council)H-Index: 21
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Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and symmetrically, respectively. They are ubiquitously expressed and play fundamental roles in tumour malignancies, including glioblastoma multiforme (GBM) which presents largely deregulated Myc activity. Previously, we demonstrated that PRMT5 associates with Myc in GBM cells, modulatin...
8 CitationsSource
#1Stefania Mariani (Sapienza University of Rome)H-Index: 24
#2Giuliana Di RoccoH-Index: 16
Last. Luisa SalvatoriH-Index: 17
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The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways. Sirtuins are important modulators of adipose tissue metabolism and their expression is higher in lean than obese subjects. At present, the role of sirtuins in adipose-derived stem cells has not been investigated yet. Therefore, in this study, we evaluated the expression of the complete panel of sirtuins in adipose-derived stem cell...
16 CitationsSource
#2L. Ravenna (Sapienza University of Rome)H-Index: 10
Last. Marco Tafani (Sapienza University of Rome)H-Index: 31
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Tumors are complex tissues in which transformed cells communicate with the surrounding microenvironment and evolve traits promoting their own survival and malignancy. Hypoxia and inflammation are constant characteristics of prostate tumor microenvironment influencing both cancer stem cells and differentiated tumor cells. HIFs and NF-kB are the key regulators of the transcriptional response to hypoxic and inflammatory stresses, respectively, and a crosstalk between HIFs and NF-kB pathways has bee...
5 CitationsSource
#1L. RavennaH-Index: 10
#2Luisa SalvatoriH-Index: 17
Last. Matteo Antonio RussoH-Index: 38
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Hypoxia-inducible factors (HIFs) are key regulators of the transcriptional response to hypoxic stress. Three inducible isoforms of HIF are present in mammals. HIF1α and HIF2α are the best characterized and structurally similar isoforms, while HIF3α is the most distantly related and is less studied. The HIF3α gene undergoes complex regulation and produces a large number of long and short mRNA splice variants, which are translated into different polypeptides. These molecules primarily act as negat...
29 CitationsSource
#1Elisa Petrangeli (Sapienza University of Rome)H-Index: 19
#2Giuseppe Coroniti (Sapienza University of Rome)H-Index: 4
Last. Luisa SalvatoriH-Index: 17
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Low-grade chronic inflammation is a salient feature of obesity and many associated disorders. This condition frequently occurs in central obesity and is connected to alterations of the visceral adipose tissue (AT) microenvironment. Understanding how obesity is related to inflammation may allow the development of therapeutics aimed at improving metabolic parameters in obese patients. To achieve this aim, we compared the features of two subpopulations of adipose-derived stem cells (ASC) isolated f...
19 CitationsSource
#1Stefania Mariani (Sapienza University of Rome)H-Index: 24
#2Daniela Fiore (Sapienza University of Rome)H-Index: 14
Last. Lucio Gnessi (Sapienza University of Rome)H-Index: 35
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Sirtuins (SIRTs) are master metabolic regulators with protective roles against obesity and obesity-associated metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and type-2 diabetes. We aimed to ascertain whether there is a relationship between serum SIRT1 and liver steatosis severity in obese patients. Seventy-two obese patients (BMI ≥ 30 kg/m2), 18 males and 54 females, mean age 39.66 ± 12.34 years, with ultrasonographic evidence of NAFLD, were studied. BMI, transaminases,...
63 CitationsSource
#1L. RavennaH-Index: 10
#2Lorenzo Principessa (Sapienza University of Rome)H-Index: 4
Last. Elisa Petrangeli (Sapienza University of Rome)H-Index: 19
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Hypoxia and inflammation are strictly interconnected both concurring to prostate cancer progression. Numerous reports highlight the role of tumor cells in the synthesis of pro-inflammatory molecules and show that hypoxia can modulate a number of these genes contributing substantially to the increase of cancer aggressiveness. However, little is known about the importance of the tumor phenotype in this process. The present study explores how different features, including differentiation and aggres...
30 CitationsSource
#1Marco Tafani (Sapienza University of Rome)H-Index: 31
#2Bruna PucciH-Index: 20
Last. Matteo Antonio Russo (Sapienza University of Rome)H-Index: 38
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HIF1α and NFkB are two transcription factors very frequently activated in tumors and involved in tumor growth, progression, and resistance to chemotherapy. In fact, HIF1α and NFkB together regulate transcription of over a thousand genes that, in turn, control vital cellular processes such as adaptation to the hypoxia, metabolic reprograming, inflammatory reparative response, extracellular matrix digestion, migration and invasion, adhesion, etc. Because of this wide involvement they could control...
56 CitationsSource
#1L. de GirolamoH-Index: 15
#2D. StancoH-Index: 12
Last. Anna T. Brini (University of Milan)H-Index: 27
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Today adipose tissue is not just considered as the primary energy storage organ, but it is also recognized as an important endocrine tissue and an abundant source of mesenchymal stem cells (adipose-derived stem cells, ASCs). During the last decade, several studies have provided preclinical data on the safety and efficacy of ASCs, supporting their use in cell-based therapy for regenerative medicine purposes. Little is known about the effect of obesity on ASCs properties. Since ASCs differentiatio...
36 CitationsSource
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