Ralph A. Bradshaw
University of California, Irvine
NeuriteInternal medicineEndocrinologyMolecular biologyPeptide sequenceReceptorEnzymeChemistryGrowth factorEpidermal growth factorNerve growth factorChromatographyAmino acidBiochemistrySignal transductionStereochemistryFibroblast growth factorBiologyNeurotrophinCell biology
Publications 310
#1E. Brad Thompson (UTMB: University of Texas Medical Branch)H-Index: 49
#2Ralph A. Bradshaw (UCI: University of California, Irvine)H-Index: 79
Cell-signaling pathways are not simply linear, but in fact form extensive interactive networks. Indeed it is the overlapping and interconnecting nature of these that provides the distinctive features distinguishing many of the response properties of specific tissues and organs. The complexity of these networks will require a great deal of research before their organization is understood in detail, but some generalities are beginning to emerge. The advent of the techniques of genomics, including ...
#1Ralph A. Bradshaw (UCSF: University of California, San Francisco)H-Index: 79
#2Edward A. Dennis (UCSD: University of California, San Diego)H-Index: 113
Publisher Summary The central importance of the general phenomenon of sensing of external stimuli by cells has been appreciated for a long time, but has truly become a dominant part of cell and molecular biology research in the past two decades, in part because a description of the dynamic responses of cells to external stimuli is in essence a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to huma...
#1Ralph A. BradshawH-Index: 79
#2Alma L. BurlingameH-Index: 120
Last. Julio E. CelisH-Index: 67
view all 3 authors...
#1Ralph A. Bradshaw (UCI: University of California, Irvine)H-Index: 79
#2Christopher Hope (UCI: University of California, Irvine)H-Index: 8
Last. Kenneth W. Walker (UCI: University of California, Irvine)H-Index: 5
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#1Ralph A. Bradshaw (UCI: University of California, Irvine)H-Index: 79
#2Elizabeth Yi (UCI: University of California, Irvine)H-Index: 3
The initiator methionine residue of proteins is removed during synthesis by a specific and ubiquitous enzyme, methionine aminopeptidase (MetAP). Prokaryotes have a single gene, while eukaryotes have two isoforms. This family of metalloenzymes generally cleaves substrates in which the penultimate residue is one of the seven smaller amino acids (glycine, alanine, serine, threonine, proline, cysteine and valine). One of the eukaryotic isoforms (MetAP2) has an additional non-proteolytic function and...
Although the fanfare and not just a little hype that surrounded the release of the (almost) complete human genome was a little theatrical for my taste, it clearly marked a watershed in human scientific endeavors and was unquestionably the product of the efforts of a relatively small number of visionaries. Unlike other mammoth biological projects, such as the “War on Cancer” of the 1970s, this endeavor had a reasonably well defined goal that was approachable and only lacked superior technological...
#1Erik D Foehr (UCI: University of California, Irvine)H-Index: 4
Abstract To assess the contribution of the intracellular domain tyrosine residues to the signaling capacity of fibroblast growth factor receptor 1 (FGFR1), stably transfected chimeras bearing the ectodomain of the platelet-derived growth factor receptor (PDGFR) and the endodomain of FGFR1 were systematically altered by a tyrosine to phenylalanine bloc and individual conversions. The 15 tyrosine residues of the endodomain of this construct (PFR1) were divided into four linear segments (labeled A,...
#1Robin Farias-Eisner (UCLA: University of California, Los Angeles)H-Index: 30
#2Linda Vician (UCLA: University of California, Los Angeles)H-Index: 15
Last. Harvey R. HerschmanH-Index: 102
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We previously identified the urokinase plasminogen activator receptor (UPAR) as a gene induced by nerve growth factor (NGF), but not by epidermal growth factor (EGF), in PC12 cells (Farias-Eisner et al. [2000] J. Neurosci. 20:230–239). Antisense oligonucletides for the UPAR mRNA or an antibody directed against UPAR protein, added simultaneously with NGF, block NGF-induced morphological and biochemical differentiation of PC12 cells. In this report, we show that anti-UPAR antibody blocks morpholog...
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