Robert P. Casillas
MRIGlobal
PathologyGene expressionMolecular biologyProinflammatory cytokineChemistryImmunologyIn vivoInflammationHuman skinDermisHairlessWound healingSulfur mustardEdemaToxicityBiochemistryMedicineBiologyCell biologyPharmacology
44Publications
20H-index
1,216Citations
Publications 45
Newest
#1Rama Malaviya (RU: Rutgers University)H-Index: 14
#2Alyssa Bellomo (RU: Rutgers University)
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
view all 11 authors...
Abstract null null Sulfur mustard (SM) is a bifunctional alkylating agent that causes severe injury to the respiratory tract. This is accompanied by an accumulation of macrophages in the lung and the release of the proinflammatory cytokine, tumor necrosis factor (TNF)α. In these studies, we analyzed the effects of blocking TNFα on lung injury, inflammation and oxidative stress induced by inhaled SM. Rats were treated with SM vapor (0.4 mg/kg) or air control by intratracheal inhalation. This was ...
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#1Robert P. CasillasH-Index: 20
#2Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
Last. Joshua P. Gray (United States Coast Guard Academy)H-Index: 19
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Chemical exposure emergencies posing a serious threat to the health and survival of civilians can be caused by terrorism events or industrial accidents. The National Institutes of Health (NIH) deve...
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#1Neera Tewari-Singh (University of Colorado Denver)H-Index: 17
#2Dinesh G Goswami (University of Colorado Denver)H-Index: 8
Last. Rajesh Agarwal (University of Colorado Denver)H-Index: 104
view all 10 authors...
#1Diane E. HeckH-Index: 38
#2Irene M. WohlmanH-Index: 3
Last. Jeffrey D. LaskinH-Index: 69
view all 9 authors...
Vesicants including sulfur mustard (SM, bis(2-chloroethyl) sulfide) and nitrogen mustard (NM, bis(2-chloroethyl)methylamine) are highly reactive bifunctional alkylating agents that target the skin....
#1Rajesh Agarwal (University of Colorado Denver)H-Index: 104
#2Dinesh G Goswami (University of Colorado Denver)H-Index: 8
Last. Neera Tewari-Singh (University of Colorado Denver)H-Index: 17
view all 10 authors...
#1Sally Kim (RU: Rutgers University)
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Debra L. Laskin (RU: Rutgers University)H-Index: 71
view all 9 authors...
Sulfur mustard (SM) is a chemical warfare agent that causes skin damage characterized by inflammation and blistering. We investigated leukocyte infiltration into mouse skin after SM exposure. The d...
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#1Donald R. Gerecke (RU: Rutgers University)H-Index: 18
#2Joshua P. Gray (United States Coast Guard Academy)H-Index: 19
Last. Robert P. Casillas (Battelle Memorial Institute)H-Index: 20
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This chapter describes the dermal toxicity events of the alkylating agent, sulfur mustard [bis(2-chloroethyl) sulfide], which ultimately causes detachment of the epidermis from the dermis. Skin exposure to sulfur mustard (SM) starts a series of dermal toxicity events with severity determined in part by mediators of injury that regulate inflammation, immune responses, apoptosis, necrosis, and a number of signaling pathways. This complex series of events involves a host of normal skin responses to...
4 CitationsSource
#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 13 authors...
Sulfur mustard (bis(2-chloroethyl) sulfide, SM) is a highly reactive bifunctional alkylating agent inducing edema, inflammation, and the formation of fluid-filled blisters in the skin. Medical countermeasures against SM-induced cutaneous injury have yet to be established. In the present studies, we tested a novel, bifunctional anti-inflammatory prodrug (NDH 4338) designed to target cyclooxygenase 2 (COX2), an enzyme that generates inflammatory eicosanoids, and acetylcholinesterase, an enzyme med...
18 CitationsSource
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Diane E. Heck (NYMC: New York Medical College)H-Index: 38
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
view all 10 authors...
Abstract Sulfur mustard (SM) is a bifunctional alkylating agent causing skin inflammation, edema and blistering. A hallmark of SM-induced toxicity is follicular and interfollicular epithelial damage. In the present studies we determined if SM-induced structural alterations in hair follicles and sebaceous glands were correlated with cell damage, inflammation and wound healing. The dorsal skin of hairless mice was treated with saturated SM vapor. One to seven days later, epithelial cell karyolysis...
10 CitationsSource
#1Yi-Hua Jan (RU: Rutgers University)H-Index: 8
#2Diane E. HeckH-Index: 38
Last. Jeffrey D. LaskinH-Index: 69
view all 6 authors...
Oxidative stress plays a key role in mechlorethamine (methylbis(2-chloroethyl)amine, HN2) toxicity. The thioredoxin system, consisting of thioredoxin reductase (TrxR), thioredoxin, and NADPH, is important in redox regulation and protection against oxidative stress. HN2 contains two electrophilic side chains that can react with nucleophilic sites in proteins, leading to changes in their structure and function. We report that HN2 inhibits the cytosolic (TrxR1) and mitochondrial (TrxR2) forms of Tr...
13 CitationsSource