Haralambos Gavras
Boston University
Internal medicineEndocrinologyPlasma renin activityCardiologyReceptorHemodynamicsChemistryRenin–angiotensin systemAngiotensin-converting enzymeVasopressinEssential hypertensionHeart failureAldosteroneCaptoprilBradykininAngiotensin IIVascular resistanceMedicineBlood pressureBiologyPharmacology
Publications 381
#1Gerasimos A. Rassias (University of Patras)H-Index: 17
Last. Dionissios PapaioannouH-Index: 15
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Βradykinin stimulation of B2 receptor is known to activate the oncogenic ERK pathway and overexpression of bradykinin receptors B1 and B2 has been reported to occur in glioma, colorectal and cervical cancers. B1R and B2R antagonists have been shown to reverse tumor proliferation and invasion. Paradoxically, B1R and B2R agonism has also been reported to elicit antiproliferative benefits. In order to complement the data accumulated to date with the natural substrate bradykinin and peptidic B2R ant...
1 CitationsSource
#1M. MarketouH-Index: 11
#1Maria E. MarketouH-Index: 15
Last. P.E. VardasH-Index: 27
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#1Michael BursztynH-Index: 30
#2Margaret BresnahanH-Index: 19
Last. Haralambos GavrasH-Index: 72
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The purpose of this study was to examine pressor hormones and platelet o^-adrenergic receptors in elderly unmedicated free-living subjects. Eighty-seven subjects, 70±5 years old (mean±SD), hypertensive or nonnotensive (blood pressure < 160/90 mm Hg) were recruited for measurement of blood levels of norepinephrine, epinephrine, and vasopressin, as well as density and affinity of «2-adrenergic receptors from platelet membranes, assessed by maximal binding (B^J and dissociation constant (A^) of rau...
#1Mary E. MarketouH-Index: 12
#2Joanna E. KontarakiH-Index: 11
Last. P.E. VardasH-Index: 27
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Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension
7 CitationsSource
#1N. KouremenosH-Index: 3
#1Nikos KouremenosH-Index: 2
Last. Haralambos GavrasH-Index: 72
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sity (USA), we studied the role of various genes and single nucleotide polymorphisms (SNPs) in the inheritance or the onset of HTN in African-American, Caucasian-American and Greek families. Methods: Among 128 Greek families with a history of HTN, we studied 1474 people. Of the total examined, 273 men and 286 women were hypertensive. Based on 410 DNA samples from the hypertensive subjects, different SNPs were examined. An overall meta-analysis of the results from the Greek families, as well as a...
5 Citations
From the first description of its anatomy by T. Willis to the novel therapeutic manipulations, it is unanimously recognized that the sympathetic nervous system (SNS) holds a crucial role in cardiovascular homeostasis. The introduction of sophisticated techniques, as microneurography and regional norepinephrine spillover provided the evidence for the role of sympathetic overactivity in various cardiovascular disease entities. Sympathetic activation is common in patients with essential hypertensio...
55 CitationsSource
#1Maria E. MarketouH-Index: 15
#2Ekaterina Kintsurashvili (BU: Boston University)H-Index: 11
Last. Haralambos Gavras (BU: Boston University)H-Index: 72
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Abstract Background Platelets play a vital role in hemostasis and thrombosis. Catecholamines have a profound effect on platelet aggregation and atherothrombosis but the exact mechanism involved is insufficiently understood. In this report, we demonstrate the existence and role of alpha2B-adrenergic receptors (α2B-ARs) in normal human platelets. Methods Sixteen healthy individuals were recruited as donors of normal blood from which platelets were isolated. The presence of α2B-ARs in platelets was...
8 CitationsSource
#1Mary E. MarketouH-Index: 12
Last. P.E. VardasH-Index: 27
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Purpose: Platelets play a vital role in hemostasis and thrombosis. Catecholamines have a profound effect on platelet aggregation and atherothrombosis but the exact mechanism involved is insufficiently understood. In this report, we demonstrate the existence and role of alpha2B–adrenergic receptors (α2B–ARs) in platelets from patients with Coronary Artery Disease (CAD) compared to normal individuals. Methods: Sixteen healthy individuals and 7 patients with CAD who were under dual antiplatelet the...
1 CitationsSource
#1Irene Gavras (BU: Boston University)H-Index: 54
#2Haralambos GavrasH-Index: 72
It is widely believed that salt-dependent hypertension is induced and maintained by expansion of intravascular fluid volume resulting from excessive retention of sodium. The purpose of this brief article is to present a series of arguments in support of the thesis that volume overload per se does no
18 CitationsSource
#1Milka Koupenova (BU: Boston University)H-Index: 17
#2Hillary Johnston-Cox (BU: Boston University)H-Index: 12
Last. Katya Ravid (BU: Boston University)H-Index: 57
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Background—The cAMP-elevating A2b adenosine receptor (A2bAR) controls inflammation via its expression in bone marrow cells. Methods and Results—Atherosclerosis induced by a high-fat diet in apolipoprotein E–deficient mice was more pronounced in the absence of the A2bAR. Bone marrow transplantation experiments indicated that A2bAR bone marrow cell signals alone were not sufficient to elicit this effect. Intriguingly, liver expression of the A2bAR in wild-type mice was vastly augmented by a high-f...
68 CitationsSource