Thomas Thesen
University of Houston
Magnetic resonance imagingArtificial intelligencePsychologyNeuroscienceElectrophysiologyPerceptionEpilepsyEpilepsy surgeryTemporal lobePrefrontal cortexComputer scienceBrain mappingElectroencephalographyAudiologyNeuroimagingResting state fMRIMedicineLateralization of brain function
Publications 98
#3Daniel FriedmanH-Index: 72
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 12
#2Thomas Thesen (Comprehensive Epilepsy Center)H-Index: 32
Last. Eric Halgren (UCSD: University of California, San Diego)H-Index: 89
view all 6 authors...
Models of reading emphasize that visual (orthographic) processing provides input to phonological as well as lexical-semantic processing. Neurobiological models of reading have mapped these processes to distributed regions across occipital-temporal, temporal-parietal, and frontal cortices. However, the role of the precentral gyrus in these models is ambiguous. Articulatory phonemic representations in the precentral gyrus are obviously involved in reading aloud, but it is unclear if the precentral...
#1Andre Altmann (UCL: University College London)H-Index: 26
#2Mina Ryten (UCL Institute of Neurology)H-Index: 50
Last. Edoardo Micotti (Mario Negri Institute for Pharmacological Research)H-Index: 23
view all 100 authors...
Aims: The causes of distinct patterns of reduced cortical thickness in the common human epilepsies, detectable on neuroimaging and with important clinical consequences, are unknown. We investigated the underlying mechanisms of cortical thinning using a systems-level analysis. // Methods: Imaging-based cortical structural maps from a large-scale epilepsy neuroimaging study were overlaid with highly spatially resolved human brain gene expression data from the Allen Human Brain Atlas. Cell-type dec...
#1Angelique C. Paulk (Harvard University)H-Index: 19
#2Jimmy C. Yang (Harvard University)H-Index: 6
Last. Sydney S. Cash (Harvard University)H-Index: 66
view all 43 authors...
Despite ongoing advances in our understanding of local single-cellular and network-level activity of neuronal populations in the human brain, extraordinarily little is known about their "intermediate" microscale local circuit dynamics. Here, we utilized ultra-high-density microelectrode arrays and a rare opportunity to perform intracranial recordings across multiple cortical areas in human participants to discover three distinct classes of cortical activity that are not locked to ongoing natural...
#5Yael M. Cycowicz (Ebor: University of York)H-Index: 21
The ability to process and respond to external input is critical for adaptive behavior. Why, then, do neural and behavioral responses vary across repeated presentations of the same sensory input? Spontaneous fluctuations of neuronal excitability are currently hypothesized to underlie the trial-by-trial variability in sensory processing. To test this, we capitalized on invasive electrophysiology in neurosurgical patients performing an auditory discrimination task with visual cues: specifically, w...
#1Farras Abdelnour (UCSF: University of California, San Francisco)H-Index: 1
#2Michael DayanH-Index: 11
Last. Ashish Raj (UCSF: University of California, San Francisco)H-Index: 29
view all 5 authors...
Abstract The relationship between anatomic and resting state functional connectivity of large-scale brain networks is a major focus of current research. In previous work, we introduced a model based on eigen decomposition of the Laplacian which predicts the functional network from the structural network in healthy brains. In this work, we apply the eigen decomposition model to two types of epilepsy; temporal lobe epilepsy associated with mesial temporal sclerosis, and MRI-normal temporal lobe ep...
#1Karen Blackmon (St. George's University)H-Index: 2
#2Randall Waechter (St. George's University)H-Index: 10
Last. A. Desiree LaBeaud (Stanford University)H-Index: 20
view all 20 authors...
Children with Congenital Zika Syndrome and microcephaly are at high risk for epilepsy; however, the risk is unclear in normocephalic children with prenatal Zika virus (ZIKV) exposure [Exposed Children (EC)]. In this prospective cohort study, we performed epilepsy screening in normocephalic EC alongside a parallel group of normocephalic unexposed children [Unexposed Children (UC)]. We compared the incidence rate of epilepsy among EC and UC at one year of life to global incidence rates. Pregnant w...
#1Elliot H. Smith (UofU: University of Utah)H-Index: 15
#2Edward M. Merricks (Columbia University)H-Index: 7
Last. Catherine A. Schevon (Columbia University)H-Index: 32
view all 14 authors...
High frequency oscillations (HFOs) are bursts of neural activity in the range of 80 Hz or higher, recorded from intracranial electrodes during epileptiform discharges. HFOs are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting. Despite such clinical utility of HFOs, the spatial context and neuronal activity underlying these local field potential (LFP) events remains unclear. We sought to further understand the neuronal correlates of ictal high frequenc...
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 12
#2Adam Milton Morgan (UCSD: University of California, San Diego)H-Index: 4
Last. Eric Halgren (UCSD: University of California, San Diego)H-Index: 89
view all 9 authors...
ABSTRACTIntracranial electrophysiology (iEEG) studies using cognitive tasks contribute to the understanding of the neural basis of language. However, though iEEG is recorded continuously during clinical treatment, due to patient considerations task time is limited. To increase the usefulness of iEEG recordings for language study we provided patients with a tablet pre-loaded with media filled with natural language, wirelessly synchronised to clinical iEEG. This iEEG data collected and time-locked...
#1Anli Liu (NYU: New York University)H-Index: 16
#2Daniel Friedman (NYU: New York University)H-Index: 72
Last. Patricia Dugan (NYU: New York University)H-Index: 14
view all 6 authors...
Abstract Background Early accounts of forced thought were reported at the onset of a focal seizure, and characterized as vague, repetitive, and involuntary intellectual auras distinct from perceptual or psychic hallucinations or illusions. Here, we examine the neural underpinnings involved in conceptual thought by presenting a series of 3 patients with epilepsy reporting intrusive thoughts during electrical stimulation of the left lateral prefrontal cortex (PFC) during invasive surgical evaluati...
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