Gail A. Laughlin
University of California, San Diego
Circadian rhythmInternal medicineEndocrinologyCardiologyCognitionProspective cohort studyHazard ratioBone mineralDehydroepiandrosteroneEstrogenMenopauseContext (language use)Body mass indexPopulationSex hormone-binding globulinConfidence intervalRisk factorBreast cancerTestosteroneDiabetes mellitusHormoneMedicineCohortGerontologyBiology
212Publications
65H-index
10.9kCitations
Publications 199
Newest
#1Eric S. OrwollH-Index: 118
#2Jodi LapidusH-Index: 36
Last. Claes OhlssonH-Index: 116
view all 17 authors...
Measurement of serum testosterone (T) levels is recommended in the evaluation of osteoporosis in older men and estradiol (E2) and sex hormone binding globulin (SHBG) levels are associated with the rate of bone loss and fractures, but the clinical utility of sex steroid and SHBG measurements for the evaluation of osteoporosis in men has not been examined. To evaluate whether measurements of T, E2, and/or SHBG are useful for the prediction of fracture risk or the rate of bone loss in older men, we...
23 CitationsSource
The added value of blood pressure (BP) trajectories for predicting cardiovascular disease (CVD) is currently unknown. We investigated the association of systolic BP (SBP) trajectories with CVD and all-cause mortality and compared these associations with those of average SBP, taking antihypertensive medication into account. Data from 762 participants of the Rancho Bernardo Study were used. SBP from five examinations (maximum) from 1984 to 2002 was used; mortality data were obtained from 2002 to 2...
#1Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. E. Barrett-ConnorH-Index: 35
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This study examines sex and age differences in associations of systolic and diastolic blood pressure (SBP, DBP), pulse pressure and hypertension with cognitive function in a community-dwelling population.Cross-sectional study.Research clinic visit in 1988-91.Participants were 693 men and 1022 women aged 50-97 Measurements: Blood pressure was measured and 12 cognitive function tests were administered.Average age was 73.8±9.9 in men and 73.2±9.3 in women; 62.6% of men and 63.4% of women were hyper...
7 CitationsSource
#1Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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BACKGROUND: Evidence of a role for vitamin D (VitD) in cognitive aging is mixed and based primarily on extreme VitD deficiency. We evaluated the association of VitD insufficiency with cognitive function in older, community-dwelling adults living in a temperate climate with year-round sunshine. METHODS: A population-based longitudinal study of 1,058 adults (median age 75; 62% women) who had cognitive function assessed and serum levels of 25-hydroxyvitaminD (25OHD) measured in 1997-99 and were fol...
12 CitationsSource
#1Erin Richard (UCSD: University of California, San Diego)H-Index: 12
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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To better understand the association of alcohol intake with cognitively healthy longevity (CHL), we explored the association between amount and frequency of alcohol intake and CHL among 1,344 older community-dwelling adults. Alcohol intake was assessed by questionnaire in 1984-1987. Cognitive function was assessed in approximate four-year intervals between 1988 and 2009. Multinomial logistic regression, adjusting for multiple lifestyle and health factors, was used to examine the association betw...
15 CitationsSource
#1Toni M. Rush (UCSD: University of California, San Diego)H-Index: 2
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Linda K. McEvoy (UC: University of California)H-Index: 66
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Objective To examine the association of dietary sodium intake with cognitive function in community-dwelling older adults.
9 CitationsSource
#1C. McDaniels-Davidson (UCSD: University of California, San Diego)H-Index: 3
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Deborah M. Kado (UCSD: University of California, San Diego)H-Index: 35
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Abstract Purpose Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults. Methods Between 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis mea...
Source
#1Gina N Woods (UCSD: University of California, San Diego)H-Index: 8
#2Mei-Hua Huang (UCLA: University of California, Los Angeles)H-Index: 20
Last. Deborah M. Kado (UCSD: University of California, San Diego)H-Index: 35
view all 10 authors...
: Accentuated kyphosis is associated with adverse health outcomes, including falls and fractures. Low bone density is a risk factor for hyperkyphosis, and each vertebral fracture adds roughly 4° to forward spine curvature. Sex steroids, in particular low bioavailable estradiol and high sex hormone-binding globulin (SHBG), are associated with bone loss and high SHBG is associated with vertebral fractures in older men. We, therefore, hypothesized that low bioavailable estradiol and high SHBG would...
5 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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BACKGROUND: Evidence suggests that moderate alcohol consumption may protect against cognitive decline and dementia. However, uncertainty remains over the patterns of drinking that are most beneficial. OBJECTIVE: To examine associations between amount and frequency of alcohol consumption with multiple domains of cognitive function in a well-characterized cohort of older community-dwelling adults in southern California. DESIGN: Observational, cross-sectional cohort study. SETTING: A research visit...
15 CitationsSource
#1Timothy J. KeyH-Index: 166
#2Paul N. ApplebyH-Index: 93
Last. Marc J. GunterH-Index: 73
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