Maxim Puchkov
University of Basel
ParticlePorosimetryInternal medicineEngineeringBiomedical engineeringSolubilityNanotechnologyBioavailabilityChemistryMaterials sciencePlaceboMoxidectinAlbendazoleExcipientCalcium carbonateMebendazoleDrug deliveryDrugChemical engineeringChromatographyPorosityMedicineDosage formDissolutionPharmacology
51Publications
14H-index
597Citations
Publications 51
Newest
#1Viktoria Schreiner (University of Basel)H-Index: 1
#2Pascal Detampel (University of Basel)H-Index: 9
Last. Jörg Huwyler (University of Basel)H-Index: 49
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Abstract Buprenorphine is a short-acting analgesic drug. Its use in veterinary medicine requires several injections per day to alleviate pain in animals. We, therefore, designed a poly-lactic-co-glycolic acid (PLGA) based depot formulation of the opioid to prolong the analgesic effect. We characterized our novel microparticulate depot formulation with emphasis on a potential future product development in the present work. Microparticles showed low residual moisture levels and did meet bacterial ...
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#1Fabio Bachmann (University of Basel)H-Index: 5
#2Urs Duthaler (University of Basel)H-Index: 16
Last. Stephan Krähenbühl (University of Basel)H-Index: 70
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Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4. So far, it is unknown whether metamizole induces additional CYPs and by which mechanism. Therefore, we assessed the activity of 6 different CYPs in 12 healthy male subjects before and after treatment with 3 g of metamizole per day for 1 week using a phenotyping cocktail approach. In addition, we investigated whether m...
2 CitationsSource
#1Daniel Preisig (University of Basel)H-Index: 4
#2Felipe J.O. VarumH-Index: 11
Last. Manuel Haschke (University Hospital of Basel)H-Index: 16
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Abstract Drug delivery to the colon offers great promise for local treatment of colonic diseases as it allows bypassing systemic absorption in the small intestine, thereby increasing luminal drug concentrations in the colon. The primary objective of this in vivo pharmaco-scintigraphy study was to assess the colon drug targeting accuracy of a metronidazole benzoate colonic drug delivery system intended for local treatment of Clostridioides difficile infections. Additionally, it was assessed if th...
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#1A. SchittnyH-Index: 3
Last. Jörg HuwylerH-Index: 49
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Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug absorption mechanisms from ASDs in humans is incomplete. Aiming to gain insights in this matter, we conducted a randomized cross-over design open-label clinical study (NCT03886766) with 16 healthy male volunteers in an ambulatory setting, using micro-dosed efavirenz as a model drug. In three phases, subjects were administered (1) solid AS...
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#2Klara KieneH-Index: 3
Last. Jörg HuwylerH-Index: 49
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There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of a novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium carbonate/calcium phosphate carrier material as the main excipient. They were assessed in a cross-sectional acceptability study. The 40 child participants were between 2 to 5 years and 6 to 10 years old. One pODT with 5 mm diameter was administered to each participatin...
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#1A. Schittny (University of Basel)H-Index: 3
#2Jörg Huwyler (University of Basel)H-Index: 49
Last. Maxim Puchkov (University of Basel)H-Index: 14
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AbstractAmorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble drugs. However, their use in drug development is comparably rare due to a lack of basic understand...
58 CitationsSource
#1Maryam Farzan (University of Basel)H-Index: 4
#2Gabriela Québatte (University of Basel)H-Index: 6
Last. Maxim Puchkov (University of Basel)H-Index: 14
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Despite the wide-spread use of liposomal drug delivery systems, application of these systems for oral purposes is limited due to their large-scale formulation and storage issues. Proliposomes are one of the formulation approaches for achieving solid powders that readily form liposomes upon hydration. In this work, we investigated a dry powder formulation of a model low-soluble drug with phospholipids loaded in porous functionalized calcium carbonate microparticles. We characterized the liposome ...
2 CitationsSource
#1Emre Cörek (University of Basel)H-Index: 2
#2Griffin Rodgers (University of Basel)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
view all 14 authors...
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#1Emre Cörek (University of Basel)H-Index: 2
#2Griffin Rodgers (University of Basel)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
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Metal-based nanoparticles are clinically used for diagnostic and therapeutic applications. After parenteral administration, they will distribute throughout different organs. Quantification of their distribution within tissues in the 3D space, however, remains a challenge owing to the small particle diameter. In this study, synchrotron radiation-based hard X-ray tomography (SRμCT) in absorption and phase contrast modes is evaluated for the localization of superparamagnetic iron oxide nanoparticle...
2 CitationsSource
Zusammenfassung. Opioide zur Schmerztherapie werden zunehmend missbraucht. Dies hat in Anbetracht zahlreicher Todesfalle vor allem in den USA zu einer «Opioid-Krise» gefuhrt. Wir zeigen im Folgende...
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