Susan C. Nagel
University of Missouri
Environmental chemistryContaminationOffspringInternal medicineEndocrinologyFetusChemistryEstrogenBenzhydryl compoundsHydraulic fracturingXenoestrogenEndometriosisBisphenol ADiethylstilbestrolEnvironmental sciencePhysiologyEndocrine systemGestationNatural gasHormoneMedicineEstrogen receptorBiologyWastewater
82Publications
30H-index
5,663Citations
Publications 77
Newest
#1Mohamed Bayati (MU: University of Missouri)H-Index: 6
#2Danh C. VuH-Index: 9
Last. Chung-Ho Lin (MU: University of Missouri)H-Index: 21
view all 13 authors...
Children are particularly vulnerable to many classes of the volatile organic compounds (VOCs) detected in indoor environments. The negative health impacts associated with chronic and acute exposures of the VOCs might lead to health issues such as genetic damage, cancer, and disorder of nervous systems. In this study, 40 VOCs including aldehydes and ketones, aliphatic hydrocarbons, esters, aromatic hydrocarbons, cyclic terpenes, alcohols, and glycol ethers were identified and qualified in differe...
Source
#1Christopher D. Kassotis (Duke University)H-Index: 17
#2Jennifer S. Harkness (USGS: United States Geological Survey)H-Index: 12
Last. Susan C. Nagel (MU: University of Missouri)H-Index: 30
view all 13 authors...
The rise of hydraulic fracturing and unconventional oil and gas (UOG) exploration in the United States has increased public concerns for water contamination induced from hydraulic fracturing fluids and associated wastewater spills. Herein, we collected surface and groundwater samples across Garfield County, Colorado, a drilling-dense region, and measured endocrine bioactivities, geochemical tracers of UOG wastewater, UOG-related organic contaminants in surface water, and evaluated UOG drilling p...
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#1Susan C. Nagel (MU: University of Missouri)H-Index: 30
#2Christopher D. Kassotis (Duke University)H-Index: 17
Last. V.D. Balise (UNM: University of New Mexico)H-Index: 1
view all 6 authors...
Abstract Unconventional oil and natural gas extraction (UOG) combines directional drilling and hydraulic fracturing and produces billions of liters of wastewater per year. Herein, we review experimental studies that evaluated the potential endocrine-mediated health impacts of exposure to a mixture of 23 UOG chemicals commonly found in wastewater. The purpose of this manuscript is to synthesize and summarize a body of work using the same UOG-mix but with different model systems and physiological ...
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#1Sadia AkterH-Index: 4
#2Dong XuH-Index: 75
Last. Trupti JoshiH-Index: 39
view all 7 authors...
Endometriosis is a complex and high impact disease affecting 176 million women worldwide with diagnostic latency between 4 to 11 years due to lack of a definitive clinical symptom or a minimally invasive diagnostic method. In this study, we developed a new ensemble machine learning classifier based on chromosomal partitioning, named GenomeForest and applied it in classifying the endometriosis vs. the control patients using 38 RNA-seq and 80 enrichment-based DNA-methylation (MBD-seq) datasets, an...
#1Lise Saffran (MU: University of Missouri)H-Index: 4
#2Sisi Hu (MU: University of Missouri)H-Index: 1
Last. Susan C. Nagel (MU: University of Missouri)H-Index: 30
view all 5 authors...
This study develops a measure of perceived authenticity in science communication and then explores communication strategies to improve the perceived authenticity of a scientific message. The findings are consistent with literature around trust and credibility, but indicate that authenticity-the perception that the scientist is a unique individual with qualities beyond institutional affiliations or a role in the production of the research-may add a potentially important dimension to accepted cate...
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#1Danh C. Vu (MU: University of Missouri)H-Index: 9
#2Thi L. Ho (Rice University)H-Index: 3
Last. Chung-Ho Lin (MU: University of Missouri)H-Index: 21
view all 11 authors...
Abstract Exposure to volatile organic compounds (VOCs) in child care environments has raised a public concern. This study aimed to characterize indoor VOCs in four facilities of Head Start programs in Kansas city, Missouri, investigate seasonal and spatial variations in VOC levels, and assess health risks associated with children's VOC exposure. In total, 49 VOCs including aromatic and aliphatic hydrocarbons, aldehydes, glycol ethers, esters and chlorinated hydrocarbons were identified and quant...
Source
#1Sadia Akter (MU: University of Missouri)H-Index: 4
#2Dong Xu (MU: University of Missouri)H-Index: 75
Last. Trupti Joshi (MU: University of Missouri)H-Index: 39
view all 7 authors...
Endometriosis is a complex and common gynecological disorder yet a poorly understood disease affecting about 176 million women worldwide, and causing significant impact on their quality of life and economic burden. Neither a definitive clinical symptom nor a minimally invasive diagnostic method is available thus leading to an average of 10 years of diagnostic latency. Discovery of relevant biological patterns from microarray expression or next generation sequencing (NGS) data has been advanced o...
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#1Victoria D. Balise (MU: University of Missouri)H-Index: 6
#2Jennifer N. Cornelius-Green (MU: University of Missouri)H-Index: 4
Last. Susan C. Nagel (MU: University of Missouri)H-Index: 30
view all 12 authors...
Chemicals used in unconventional oil and gas (UOG) operations can act as endocrine disrupting chemicals and metabolic disruptors. Our lab has reported altered energy expenditure and activity in C57BL/6J mice that were periconceptionally, gestationally, and lactationally exposed via maternal drinking water to a laboratory-created mixture of 23 UOG chemicals from gestational day 1 to postnatal day 21 in seven-month-old female mice with no change in body composition. We hypothesized that allowing t...
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#1Jacques Robert (UR: University of Rochester)H-Index: 51
#2Connor C. McGuire (UR: University of Rochester)H-Index: 5
Last. Francisco De Jesús Andino (UR: University of Rochester)H-Index: 13
view all 5 authors...
Abstract Although aquatic vertebrates and humans are increasingly exposed to water pollutants associated with unconventional oil and gas extraction (UOG), the long-term effects of these pollutants on immunity remains unclear. We have established the amphibian Xenopus laevis and the ranavirus Frog Virus 3 (FV3) as a reliable and sensitive model for evaluating the effects of waterborne pollutants. X. laevis tadpoles were exposed to a mixture of equimass amount of UOG chemicals with endocrine disru...
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The contamination of surface water and ground water by human activities, such as fossil fuel extraction and agriculture, can be difficult to assess due to incomplete knowledge of the chemicals and chemistry involved. This is particularly true for the potential contamination of drinking water by nearby extraction of oil and/or gas from wells completed by hydraulic fracturing. A case that has attracted considerable attention is unconventional natural gas extraction in Susquehanna County, Pennsylva...
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