Kazuhiko Kurozumi
Hamamatsu University School of Medicine
GeneGenetic enhancementInternal medicineRadiologySurgeryPathologyOncologyCellMolecular biologyIntegrinImmunologyImmunohistochemistryIn vivoGlioblastomaVascular endothelial growth factorBevacizumabGliomaCilengitideAngiogenesisCancer researchMedicineCell cultureOncolytic virusBiology
Publications 127
#1Yusuke Tomita (Okayama University)H-Index: 6
#2Yosuke Shimazu (Okayama University)H-Index: 6
Last. Isao Date (Okayama University)H-Index: 58
view all 12 authors...
Ventriculitis is a rare, serious complication of neurosurgery. A 59-year-old man who had undergone a craniotomy for a paranasal adenocarcinoma, developed a right frontal cystic lesion. We performed a bifrontal craniotomy to remove the lesion. The dura was repaired with non-vascularized free fascia lata in watertight fashion. Ventriculitis occurred 3 days postoperatively. Ventricular drainage, craniectomy, and endoscopic irrigation were undertaken to remove an abscess. The dura and the resection ...
#1Shunsuke Noguchi (OPU: Osaka Prefecture University)H-Index: 16
#2Marina Inoue (OPU: Osaka Prefecture University)
Last. Hiroaki Kamishina (Gidai: Gifu University)H-Index: 8
view all 8 authors...
Abstract Canine glioma is a common brain tumor with poor prognosis despite surgery and/or radiation therapy. Therefore, newer and more effective treatment modalities are needed. Neuregulin 3 (NRG3) has known to be a ligand of ERBB4. This study aimed to investigate the usefulness of the NRG3/ERBB4 signaling cascade as a novel therapeutic target in canine glioma. We found out that microRNA (miR)-190a was downregulated in canine brain tumor tissues, including glioma and meningioma. miR-190a directl...
1 CitationsSource
#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 15 authors...
Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment....
4 CitationsSource
#1Hirokazu Takami (National Cancer Research Institute)H-Index: 11
#2Kaishi Satomi (National Cancer Research Institute)H-Index: 13
Last. Nobuhito Saito (UTokyo: University of Tokyo)H-Index: 32
view all 38 authors...
#1Akira Shimada (Okayama University)H-Index: 56
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Masahiro Shin (UTokyo: University of Tokyo)H-Index: 28
view all 9 authors...
#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Masahiro Kameda (Okayama University)H-Index: 21
Last. Isao Date (Okayama University)H-Index: 58
view all 6 authors...
#1Hideyuki Arita (Osaka University)H-Index: 17
#2Yuko MatsushitaH-Index: 14
Last. Koichi IchimuraH-Index: 58
view all 51 authors...
TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these mutations have an impact on patient survival independent of 1p/19q codeletion is unknown. In this study, we investigated the impact of TERT promoter mutations on survival in IDH-mutated glioma cases. Detailed clinical information and molecular status data were collected for a cohort of 560 adult patients with IDH-mutated gliomas. Among these patients, 279 had both TERT promoter m...
5 CitationsSource
#1Yusuke TomitaH-Index: 6
#2Kazuhiko KurozumiH-Index: 23
Last. Isao DateH-Index: 58
view all 5 authors...
Breast cancer is the most common malignancy among women worldwide, and the main cause of death in patients with breast cancer is metastasis. Metastasis to the central nervous system occurs in 10% to 16% of patients with metastatic breast cancer, and this rate has increased because of recent advancements in systemic chemotherapy. Because of the various treatments available for brain metastasis, accurate diagnosis and evaluation for treatment are important. Magnetic resonance imaging (MRI) is one ...
#1Masafumi Hiramatsu (Okayama University)H-Index: 7
#2Kenji Sugiu (Okayama University)H-Index: 26
Last. Isao Date (Okayama University)H-Index: 58
view all 13 authors...
BACKGROUND AND PURPOSE: Detailed arterial anatomy of the sphenoid ridge and olfactory groove meningiomas is complicated due to the fine angioarchitecture and anastomoses between each feeder. Herein, we present details of the arterial anatomy and the relationships of feeders in these lesions. MATERIALS AND METHODS: This study included 20 patients admitted to our department between April 2015 and March 2020. Conditions of subjects consisted of 16 sphenoid ridge meningiomas and 4 olfactory groove m...
2 CitationsSource
#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Koji HirashitaH-Index: 6
Last. Isao Date (Okayama University)H-Index: 58
view all 7 authors...
Methotrexate (MTX) is an immunosuppressor that is widely used to treat autoimmune diseases, including rheumatoid arthritis (RA). However, it can have serious adverse effects including a lymphoma: MTX-associated lymphoproliferative disorder (MTX-LPD). Extranodal lesions are common in MTX-LPD patients. However, MTX-LPD in the central nervous system (CNS) is extremely rare with few reported cases. Here, we describe a case of primary CNS MTX-LPD in a patient with RA, with a review of the literature....
1 CitationsSource