Eri Nakamura
Okayama University
PhosphorylationInternal medicineMitogen-activated protein kinaseEndocrinologyPathologyCell signalingEndogenyReceptorChemistryPediatricsIn vivoAromataseSomatostatinRUNX2OocyteEosinophiliaEstrogenGranulosa cellMelatoninOsteoblastCorticotropin-releasing hormoneAldosteroneProlactinForskolinMEDLINESteroidogenic acute regulatory proteinOvarian follicleEosinophilic pneumoniaMelatonin receptorFollicle-stimulating hormone receptorBone morphogenetic proteinMAPK/ERK pathwaySignal transductionMedicineProtein kinase BSomatostatin receptorCholesterol side-chain cleavage enzymeEstrogen receptorBiologyGastroenterologyCell biology
26Publications
13H-index
379Citations
Publications 26
Newest
#1Masaya IwamuroH-Index: 17
#2Kosuke KimuraH-Index: 5
Last. Hiroyuki OkadaH-Index: 62
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An 82-year-old Japanese man presented with a gastric involvement of peripheral T-cell lymphoma, not otherwise specified. Although gastrointestinal lesions were not detected on computed tomography, oesophagogastroduodenoscopy revealed a slight elevation of the gastric mucosa, with changes in mucosal colour and the presence of abnormal microvessels. This led to the prompt detection of gastric involvement in lymphoma. This case highlights the usefulness of detailed observation of the gastric mucosa...
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#1Tokiko Urabe (Okayama University)
#2Hideharu Hagiya (Okayama University)H-Index: 13
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 4 authors...
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#1Hideharu Hagiya (Okayama University)H-Index: 13
#2Eri Nakamura (Okayama University)H-Index: 13
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 10 authors...
1 CitationsSource
#1Takayuki HaraH-Index: 4
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
Abstract Melatonin has been reported to suppress adrenocorticotropin (ACTH) secretion in the anterior pituitary and cortisol production in the adrenal by different mechanisms. However, the effect of melatonin on aldosterone production has remained unknown. In this study, we investigated the role of melatonin in the regulation of aldosterone production using human adrenocortical H295R cells by focusing on the activin system expressed in the adrenal. Melatonin receptor MT1 mRNA and protein were ex...
7 CitationsSource
#1Satoshi Akao (Okayama University)
#2Hideharu Hagiya (Okayama University)H-Index: 3
Last. Fumio Otsuka (Okayama University)H-Index: 35
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#1Takeshi Hosoya (Okayama University)H-Index: 6
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
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Abstract BMPs expressed in the ovary differentially regulate steroidogenesis by granulosa cells. BMP-9, a circulating BMP, is associated with cell proliferation, apoptosis and differentiation in various tissues. However, the effects of BMP-9 on ovarian function have yet to be elucidated. Here we investigated BMP-9 actions on steroidogenesis using rat primary granulosa cells. BMP-9 potently suppressed FSH-induced progesterone production, whereas it did not affect FSH-induced estradiol production ...
20 CitationsSource
#1Koichi WasedaH-Index: 9
#2Hideharu HagiyaH-Index: 13
Last. Fumio OtsukaH-Index: 35
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An 81-year-old Japanese male with primary Sjogren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefor...
2 CitationsSource
#1Hideharu Hagiya (Okayama University)H-Index: 3
#2Kou Hasegawa (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
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: A 34-year-old man with 22q11.2 deletion syndrome (DiGeorge syndrome) concurrently suffered from myopathy and eosinophilic pneumonia shortly after receiving daptomycin (DAP) for right-sided infective endocarditis. The simultaneous occurrence of these phenomena in relation to DAP therapy has not been previously well described. An allergic reaction was suspected as a possible etiology of these DAP-related complications. This case highlights the need for close observation in order to detect both m...
6 CitationsSource
#1Tomohiro Terasaka (Okayama University)H-Index: 10
#2Hideharu HagiyaH-Index: 13
Last. Fumio OtsukaH-Index: 35
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We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only th...
1 CitationsSource
#1Eri Nakamura (Okayama University)H-Index: 13
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 8 authors...
Abstract The ovarian bone morphogenetic protein (BMP) system is a physiological inhibitor of luteinization in growing ovarian follicles. BMP-6, which is expressed in oocytes and granulosa cells of healthy follicles, specifically inhibits FSH actions by suppressing adenylate cyclase activity. In the present study, we studied the role of melatonin in ovarian steroidogenesis using rat primary granulosa cells of immature female rat ovaries by focusing on the interaction with BMP-6 activity. Treatmen...
16 CitationsSource