Ioannis Psallidas
Churchill Hospital
Internal medicineRadiologySurgeryPathologyEffusionRandomized controlled trialIntensive care medicineMalignant pleural effusionPleural diseasePleurodesisMesotheliomaLungPneumothoraxThoracoscopyPleural effusionPleural infectionPleural fluidCancer researchMedicine
183Publications
24H-index
1,833Citations
Publications 183
Newest
#1Dave Singh (University of Manchester)H-Index: 75
#2Jutta BeierH-Index: 18
Last. Jaclyn A. Smith (University of Manchester)H-Index: 49
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BACKGROUND Navafenterol (AZD8871) belongs to a new class of bronchodilator, the single-molecule muscarinic antagonist and beta agonist (MABA), being developed for the treatment of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the efficacy, pharmacokinetics and safety of navafenterol versus placebo and an active comparator treatment for moderate-to-severe COPD. METHODS This phase 2a, randomised, multicentre (Germany and UK), double-blind, double-dummy, three-way compl...
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#1Rachelle Asciak (Churchill Hospital)H-Index: 7
#2Nikolaos I. Kanellakis (Churchill Hospital)H-Index: 12
Last. Stephen Montefort (Mater Dei Hospital)H-Index: 29
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BACKGROUND Most patients with malignant pleural mesothelioma (MPM) present with malignant pleural effusion (MPE). There is in vitro evidence that MPE may not be a simple bystander of malignancy, but potentially has biological properties improving cancer cell survival and promoting cancer progression. If this is the case, MPE management may need to shift from current symptomatic strategies to aggressive fluid removal to impact on survival. RESEARCH QUESTION Is there an association between pleural...
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#1S. Tsim (Glas.: University of Glasgow)H-Index: 5
#2Laura Alexander (Glas.: University of Glasgow)H-Index: 8
Last. Davand Sharma (Inverclyde Royal Hospital)
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Introduction null Malignant pleural mesothelioma (MPM) is difficult to diagnose. An accurate blood biomarker could prompt specialist referral or be deployed in future screening. In earlier retrospective studies, SOMAscan® proteomics and Fibulin-3 appeared highly accurate, but SOMAscan® has not been validated prospectively and subsequent Fibulin-3 data have been contradictory. null Methods null A multi-centre prospective observational study was performed in 22 centres, generating a large intentio...
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#1Rachelle AsciakH-Index: 7
Last. Ioannis PsallidasH-Index: 24
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Objectives Patients with malignant pleural mesothelioma (MPM) or pleural metastases often present with malignant pleural effusion (MPE). This study aimed to analyze the effect of pleural fluid on cancer cells. Materials and methods Established patient-derived cancer cell cultures derived from MPE (MPM, breast carcinoma, lung adenocarcinoma) were seeded in 100% pleural fluid (exudate MPM MPE, transudate MPE, non-MPE transudate fluid) and proliferation was monitored. In addition, the establishment...
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#1Ioannis PsallidasH-Index: 24
#2Vibeke Backer (UCPH: University of Copenhagen)H-Index: 59
Last. Tariq Sethi (AstraZeneca)H-Index: 2
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Rationale: To examine the potential of TLR9 activation to modulate the Type-2 immune response in asthma. Objectives: To evaluate efficacy and safety of AZD1419, an inhaled TLR9 agonist, in a phase ...
5 CitationsSource
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Rationale Asthma is characterized by chronic inflammation;inhaled corticosteroids (ICS) are the preferred antiinflammatory treatment at all severity levels. Velsecorat, a once-daily inhaled non-steroidal selective glucocorticoid receptor (GR) modulator potentially has an improved risk-benefit profile compared to ICS. The aim of this Phase 1 study (AMBER, NCT03976869) was to establish the pharmacokinetic (PK) and pharmacodynamic (PD) profile of velsecorat in adolescents to enable inclusion of thi...
#1John P. CorcoranH-Index: 18
#2I PsallidasH-Index: 1
Last. Alex WestH-Index: 10
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#2Momen M. Wahidi (Duke University)H-Index: 38
Last. Lonny Yarmus (Johns Hopkins University)H-Index: 34
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Abstrac Background The management of recurrent pleural effusions remains a challenging issue for clinicians. Advances in management have led to increased use of indwelling tunneled pleural catheters (IPC) due to their effectiveness and ease of outpatient placement. However, with the increase in IPC placement there have also been increasing reports of complications, including infections. Currently there is minimal guidance in IPC related management issues after placement. Research Question Our ob...
6 CitationsSource
#2Rachelle AsciakH-Index: 4
Last. Ioannis PsallidasH-Index: 24
view all 21 authors...
Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with cancer-specific cytotoxic T cells and showed diverse responses. Some of the biphasic...
3 CitationsSource