Lars Grip
University of Gothenburg
Internal medicineSurgeryCardiologyIntensive care medicineThrombinHeparinInfarctionAbciximabCoronary artery diseaseStentThrombolysisReperfusion injuryInogatranAngioplastyPercutaneous coronary interventionAnesthesiaConventional PCIMyocardial infarctionIschemiaMedicine
Publications 96
#1Annika OdellH-Index: 3
#2Angela Bång (UB: University of Borås)H-Index: 1
Last. Lars GripH-Index: 21
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Background Clinical decision-making is often based on evidence of outcome after a specific treatment. Healthcare providers and patients may, however, have different perceptions and expectations of what to achieve from a certain healthcare measure. Aims To evaluate patients’ expectations, perceptions and health related quality of life (HRQoL) before a care process including coronary angiography for suspected coronary artery disease and to evaluate the fulfilment of these expectations in relation ...
2 CitationsSource
#1Elias Spanos (University of Gothenburg)H-Index: 1
#2Lars O. Karlsson (University of Gothenburg)H-Index: 7
Last. Niklas Bergh (University of Gothenburg)H-Index: 10
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Abstract Eribis Peptide 94 (EP94) is an enkephalin analog with cardioprotective properties in ischemia and reperfusion. The aim of the present study was to define the optimal timing and dosing of the administration of EP94 during ischemia and reperfusion in a rat model. 172 anesthetized and mechanically ventilated male Sprague–Dawley rats were randomly assigned to different administration protocols of EP94 and subjected to 30 or 40 min of coronary artery occlusion followed by 2 h of reperfusion....
1 CitationsSource
#1Inger EkmanH-Index: 59
#2Nicky BrittenH-Index: 70
Last. Karl SwedbergH-Index: 146
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Modern care is often based on investigations such as laboratory markers and imaging - for example, x-ray or ultrasound. The results contribute to a diagnosis and, if judged necessary, treatment is initiated. This diseased-oriented approach is the prevailing mode of management in modern medicine. In contrast, person-centered care (PCC) takes the point of departure from each person´s subjective experience of illness and its impact on daily life. A patient is considered as a person with emotions an...
4 CitationsSource
#1Christina Drevinge (University of Gothenburg)H-Index: 5
#2Lars O. Karlsson (University of Gothenburg)H-Index: 7
Last. Malin Levin (University of Gothenburg)H-Index: 19
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Myocardial ischemia is associated with intracellular accumulation of lipids and increased depots of myocardial lipids are linked to decreased heart function. Despite investigations in cell culture and animal models, there is little data available on where in the heart the lipids accumulate after myocardial ischemia and which lipid species that accumulate. The aim of this study was to investigate derangements of lipid metabolism that are associated with myocardial ischemia in a porcine model of i...
20 CitationsSource
#1Karin Åström-Olsson (University of Gothenburg)H-Index: 5
#2Lizhen Li (University of Gothenburg)H-Index: 2
Last. Lars Grip (University of Gothenburg)H-Index: 21
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Aims: To establish a cardiac cell culture model for simulated ischemia and reperfusion and in this model investigate the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6, and intracellular calcium dynamics. Methods: HL-1 cell cultures were exposed to normoxia (as control), hypoxia, simulated ischemia (HEDA) or HEDA + reactive oxygen species (ROS) for up to 24 h and after HEDA, with or without ROS, followed or not by simulated reperfu...
9 CitationsSource
#1Lars O. Karlsson (University of Gothenburg)H-Index: 7
#2Niklas Bergh (University of Gothenburg)H-Index: 10
Last. Lars Grip (University of Gothenburg)H-Index: 21
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Background: In recent years, cyclosporine A (CsA) has emerged as a promising therapy to limit myocardial ischemic–reperfusion injury, presumably by inhibiting the opening of the mitochondrial permeability transition pore. Results from different large animal models are conflicting, however, with failure to prove beneficial effects of 10 mg/kg CsA administered at reperfusion. Recently, a small clinical study using a bolus of 2.5 mg/kg CsA showed promising but not unequivocal results. The aim of th...
16 CitationsSource
#1Lars O. Karlsson (University of Gothenburg)H-Index: 7
#2Niklas Bergh (University of Gothenburg)H-Index: 10
Last. Lars Grip (University of Gothenburg)H-Index: 21
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Abstract Opioids confer cardioprotection after myocardial ischaemia and reperfusion. The primary aim of the present study was to evaluate the cardioprotective effect of different doses of enkephalin analogue Eribis peptide 94 (EP 94) in a porcine model of ischaemia and reperfusion. A secondary aim was to analyse the impact of ischaemia and reperfusion on the expression of opioid receptor subtypes in the porcine heart. Thirty-four anesthetised pigs underwent 40 min of balloon occlusion of the lef...
16 CitationsSource
#1Jacob Odenstedt (University of Gothenburg)H-Index: 13
#2Bengt Linderoth (KI: Karolinska Institutet)H-Index: 66
Last. Paulin Andréll (Sahlgrenska University Hospital)H-Index: 13
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Background Susceptibility to ventricular arrhythmias and sudden cardiac death can be reduced by modulation of autonomic tone. Spinal cord stimulation (SCS) presumably affects autonomic tone and reduces myocardial ischemia. Objective The purpose of this study was to investigate whether SCS could reduce myocardial ischemia, infarct size, and ventricular arrhythmias as well as repolarization alterations in a porcine ischemia–reperfusion model. Methods Anesthetized common Landrace pigs were randomiz...
53 CitationsSource
#1Camilla Hage (KI: Karolinska Institutet)H-Index: 15
#2Lars Grip (Sahlgrenska University Hospital)H-Index: 21
Last. Nawsad Saleh (KI: Karolinska Institutet)H-Index: 10
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Aims: Patients with type 2 diabetes (T2DM) have a high restenosis rate after percutaneous coronary intervention (PCI). This study investigated whether markers of inflammation and the adipo-insular axis associated with T2DM and poor metabolic control were able to predict restenosis after PCI in T2DM patients.Methods and results: The predictive value of traditional and non-traditional risk markers, including IL-1β, IL-6, TNF-α, hsCRP, interferon gamma, leptin, IGF-I, insulin, proinsulin and NT-pro...
2 CitationsSource
#1Pauline Andréll (Sahlgrenska University Hospital)H-Index: 1
#2Olof Ekre (Sahlgrenska University Hospital)H-Index: 8
Last. Clas Mannheimer (Sahlgrenska University Hospital)H-Index: 29
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Abstract Background Refractory angina pectoris has been defined as coronary artery disease and severe angina, not available for further conventional pharmacological treatment or for revascularization procedures. The aim of the study was to assess fatality, morbidity and quality of life in patients with refractory angina. Methods Patients with refractory angina were prospectively identified at seven centres and were compared with an age and gender matched group of patients accepted for revascular...
50 CitationsSource