Barbara Illi
National Research Council
CiliumEmbryonic stem cellMolecular biologyCREBRegulation of gene expressionChromatin remodelingChemistryHistone deacetylaseDuchenne muscular dystrophyStem cellCiliopathiesEpigeneticsCancer researchNitric oxideGeneticsHistoneMedicineChromatinBiologyCell biology
Publications 56
#1Annarita Favia (National Research Council)H-Index: 8
#2Luisa Salvatori (National Research Council)H-Index: 17
Last. Barbara Illi (National Research Council)H-Index: 21
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Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and symmetrically, respectively. They are ubiquitously expressed and play fundamental roles in tumour malignancies, including glioblastoma multiforme (GBM) which presents largely deregulated Myc activity. Previously, we demonstrated that PRMT5 associates with Myc in GBM cells, modulatin...
8 CitationsSource
#1Roberta De MoriH-Index: 3
#2Mariasavina Severino (Istituto Giannina Gaslini)H-Index: 17
Last. Enza Maria Valente (UNIPV: University of Pavia)H-Index: 60
view all 22 authors...
Basal ganglia are subcortical grey nuclei that play essential roles in controlling voluntary movements, cognition and emotion. While basal ganglia dysfunction is observed in many neurodegenerative or metabolic disorders, congenital malformations are rare. In particular, dysplastic basal ganglia are part of the malformative spectrum of tubulinopathies and X-linked lissencephaly with abnormal genitalia, but neurodevelopmental syndromes characterized by basal ganglia agenesis are not known to date....
2 CitationsSource
#1Cristiana Porcu (University of L'Aquila)H-Index: 5
#2Laura Antonucci (University of L'Aquila)H-Index: 2
Last. Clara Balsano (University of L'Aquila)H-Index: 32
view all 10 authors...
// Cristiana Porcu 1, 2, * , Laura Antonucci 1, 2, * , Barbara Barbaro 1, 2 , Barbara Illi 3 , Sergio Nasi 3 , Maurizio Martini 5 , Anna Licata 4 , Luca Miele 5 , Antonio Grieco 5 and Clara Balsano 1, 2 1 MESVA Department, University of L’Aquila, L’Aquila, Italy 2 F. Balsano Foundation, Rome, Italy 3 Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy 4 DIBIMIS, University of Palermo, School of Medicine, Palermo, Italy 5 Fondazione Policlinico Universitario Gemel...
7 CitationsSource
#1Roberta De Mori (UNIME: University of Messina)H-Index: 3
#2Marta RomaniH-Index: 15
Last. Enza Maria Valente (UNIPV: University of Pavia)H-Index: 60
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The Sonic Hedgehog (SHH) pathway is a key signaling pathway orchestrating embryonic development, mainly of the CNS and limbs. In vertebrates, SHH signaling is mediated by the primary cilium, and genetic defects affecting either SHH pathway members or ciliary proteins cause a spectrum of developmental disorders. SUFU is the main negative regulator of the SHH pathway and is essential during development. Indeed, Sufu knock-out is lethal in mice, and recessive pathogenic variants of this gene have n...
17 CitationsSource
#1Silvia Galardi (University of Rome Tor Vergata)H-Index: 13
#2M. SavinoH-Index: 11
Last. Sergio NasiH-Index: 18
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MYC deregulation is common in human cancer and has a role in sustaining the aggressive cancer stem cell populations. MYC mediates a broad transcriptional response controlling normal biological programmes, but its activity is not clearly understood. We address MYC function in cancer stem cells through the inducible expression of Omomyc—a MYC‐derived polypeptide interfering with MYC activity—taking as model the most lethal brain tumour, glioblastoma. Omomyc bridles the key cancer stemlike cell fea...
25 CitationsSource
#2Mauro Savino (National Research Council)H-Index: 3
Last. Andrea LeviH-Index: 30
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// Maria Patrizia Mongiardi 1, * , Mauro Savino 2, * , Maria Laura Falchetti 1 , Barbara Illi 2 , Francesca Bozzo 3, 4 , Cristiana Valle 1, 4 , Manuela Helmer-Citterich 5 , Fabrizio Ferre 6 , Sergio Nasi 2, ** , Andrea Levi 1, ** 1 Institute of Cell Biology and Neurobiology, CNR, c/o CERC, 00143 Rome, Italy 2 Nucleic Acids Laboratory, Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR) and Department of Biology and Biotechnologies, Sapienza University, 00185 Rome, ...
13 CitationsSource
#1Maria Patrizia Mongiardi (National Research Council)H-Index: 11
#2M. Savino (National Research Council)H-Index: 11
Last. Barbara Illi (Casa Sollievo della Sofferenza)H-Index: 21
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Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells
24 CitationsSource
#1Barbara Illi (National Research Council)H-Index: 21
#2Roberta CiarapicaH-Index: 16
Last. Maurizio C. CapogrossiH-Index: 72
view all 3 authors...
Abstract DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called “epigenetic drift”, in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and his...
17 CitationsSource
#1Adi Mory (Rambam Health Care Campus)H-Index: 11
#2Efrat Dagan (University of Haifa)H-Index: 19
Last. Ruth Gershoni-Baruch (Rappaport Faculty of Medicine)H-Index: 43
view all 11 authors...
Abstract Background Kohlschutter–Tonz syndrome (KTS; MIM 22675) is a rare autosomal recessive disorder characterized by intellectual impairment, spasticity, epilepsy, and amelogenesis imperfecta. We have recently identified the causative gene and mutation underlying KTS, namely, p.R157X, corresponding to ROGDI c.571C>T, which creates a premature stop codon in ROGDI homolog (Drosophila), a gene of unknown function, in KTS patients of Druze origin. Patients To better delineate the phenotype of KTS...
7 CitationsSource
#1Sveva Romani (Casa Sollievo della Sofferenza)H-Index: 7
#2Barbara Illi (Casa Sollievo della Sofferenza)H-Index: 21
Last. Enza Maria Valente (Casa Sollievo della Sofferenza)H-Index: 60
view all 6 authors...
Abstract The dysfunction of the primary cilium, a complex, evolutionarily conserved, organelle playing an important role in sensing and transducing cell signals, is the unifying pathogenetic mechanism of a growing number of diseases collectively termed “ciliopathies”, typically characterized by multiorgan involvement. Developmental defects of the central nervous system (CNS) characterize a subset of ciliopathies showing clinical and genetic overlap, such as Joubert syndrome (JS) and Meckel syndr...
4 CitationsSource
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