Ambra Buschiazzo
University of Genoa
Internal medicineRadiologyPET-CTEndocrinologyPathologyPsychologyNeuroscienceCarbohydrate metabolismChemistryStandardized uptake valueIn vivoPositron emission tomographyDiseaseLymphomaMalignancyDementiaAmyotrophic lateral sclerosisSpinal cordDoxorubicinCognitive impairmentNuclear medicineIn patientCancer researchFunctional neuroimagingAudiologyNeuroimagingMedicineBiology
Publications 40
#1Barbara Paghera (University of Brescia)H-Index: 19
#2Daniele AltomareH-Index: 12
Last. Ugo Paolo GuerraH-Index: 17
view all 15 authors...
BACKGROUND: Three different amyloid tracers labeled with 18-flourine have been introduced into clinical use. The leaflets of tracers indicate different visual criteria for PET reporting. In clinical practice, it isn't yet ascertained whether this criteria are equivalent in terms of diagnostic accuracy or if anyone is better than another. We aimed to evaluate the inter and intra-rater variability of visual assessment of 18F-Florbetapir PET/CT images among six independent readers with different cl...
1 CitationsSource
#1Mirko MagnoneH-Index: 17
#2Laura EmioniteH-Index: 26
Last. Elena ZocchiH-Index: 45
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Abscisic acid (ABA) is a plant hormone active also in mammals where it regulates, at nanomolar concentrations, blood glucose homeostasis. Here we investigated the mechanism through which low-dose ABA controls glycemia and glucose fate. ABA stimulated uptake of the fluorescent glucose analog 2-NBDG by L6, and of [18F]-deoxy-glucose (FDG) by mouse skeletal muscle, in the absence of insulin, and both effects were abrogated by the specific AMPK inhibitor dorsomorphin. In L6, incubation with ABA incr...
5 CitationsSource
#1Domenico Albano (University of Brescia)H-Index: 24
#2Riccardo Laudicella (UNIME: University of Messina)H-Index: 8
Last. Salvatore AnnunziataH-Index: 15
view all 18 authors...
Mantle cell lymphoma (MCL) is an aggressive lymphoma subtype with poor prognosis in which 18F-FDG-PET/CT role in treatment response evaluation and prediction of outcome is still unclear. The aim of this multicentric study was to investigate the role of 18F-FDG-PET/CT in staging MCL and the prognostic role of Deauville criteria (DC) in terms of progression-free survival (PFS) and overall survival (OS). We retrospectively enrolled 229 patients who underwent baseline and end-of-treatment (eot) 18F-...
10 CitationsSource
#1Elisa Principi (UniGe: University of Genoa)H-Index: 4
#2Ambra Buschiazzo (UniGe: University of Genoa)H-Index: 16
Last. Sara Tavella (UniGe: University of Genoa)H-Index: 17
view all 12 authors...
Lipocalin-2 (LCN2) is widely expressed in the organism with pleiotropic roles. In particular, its overexpression correlates with tissue stress conditions including inflammation, metabolic disorders, chronic diseases and cancer. To assess the effects of systemic LCN2 overexpression on adipose tissue and glucose metabolism. Eighteen-month-old transgenic mice with systemic LCN2 overexpression (LCN2-Tg) and age/sex-matched wild-type mice. Metabolic cages; histology and real-time PCR analysis; glucos...
9 CitationsSource
#1Mirco Ponzoni (Istituto Giannina Gaslini)H-Index: 55
#2Flavio Curnis (UniSR: Vita-Salute San Raffaele University)H-Index: 32
Last. Fabio Pastorino (Istituto Giannina Gaslini)H-Index: 34
view all 24 authors...
: Targeted delivery of anticancer drugs with nanocarriers can reduce side effects and ameliorate therapeutic efficacy. However, poorly perfused and dysfunctional tumor vessels limit the transport of the payload into solid tumors. The use of tumor-penetrating nanocarriers might enhance tumor uptake and antitumor effects. A peptide containing a tissue-penetrating (TP) consensus motif, capable of recognizing neuropilin-1, is here fused to a neuroblastoma-targeting peptide (pep) previously developed...
14 CitationsSource
#1Cecilia MariniH-Index: 28
#2Silvia Morbelli (Health Science University)H-Index: 33
Last. Gianmario Sambuceti (Health Science University)H-Index: 48
view all 25 authors...
: We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning in amyotrophic lateral sclerosis. The present study aimed to verify the relationship between spinal cord and brain metabolism in 44 prospectively recruited patients affected by amyotrophic lateral sclerosis submitted to 18F-fluorodeoxyglucose brain and whole-body PET/CT. Patients were studied to highlight the presence of brain hypo- or hypermetabolism with respe...
25 CitationsSource
#1Letizia Zullo (IIT: Istituto Italiano di Tecnologia)H-Index: 9
#2Ambra Buschiazzo (Health Science University)H-Index: 16
Last. Gianmario Sambuceti (Health Science University)H-Index: 48
view all 8 authors...
: This study aimed to develop a method of administering 18F-FDG to the common octopus in order to perform a PET biodistribution assay characterizing glucose metabolism in organs and regenerating tissues. Methods: Seven animals (two of which had a regenerating arm) were anesthetized with 3.7% MgCl2 in artificial seawater and then injected with 18-30 MBq of isosmotic 18F-FDG through either the left branchial heart or the anterior vena cava. After an uptake time of about 50 min, the animals were sa...
8 CitationsSource
#1Mirco PonzoniH-Index: 55
#2Chiara BrignoleH-Index: 29
Last. Fabio PastorinoH-Index: 34
view all 19 authors...
Background: Anti-cancer drugs-loaded targeted nanocarriers can reduce side-effects and improve therapeutic efficacy in preclinical studies. However, poorly perfused and dysfunctional tumour vessels limit the transport of the payload into the parenchyma of solid tumours. The use of tumour-penetrating nanocarriers might enhance tumour penetration and anti-tumour effects. Methods: A consensus motif, mediator of tissue penetration (TP) was added to a previously characterized neuroblastoma (NB)-targe...
#1Ambra Buschiazzo (UniGe: University of Genoa)H-Index: 16
#2Vanessa CossuH-Index: 7
Last. Cecilia MariniH-Index: 28
view all 21 authors...
The close connection between neuronal activity and glucose consumption accounts for the clinical value of 18F-fluoro-2-deoxyglucose (FDG) imaging in neurodegenerative disorders. Nevertheless, brain metabolic response to starvation (STS) might hamper the diagnostic accuracy of FDG PET/CT when the cognitive impairment results in a severe food deprivation. Thirty six-week-old BALB/c female mice were divided into two groups: “control” group (n = 15) were kept under standard conditions and exposed to...
8 CitationsSource
#1Cecilia MariniH-Index: 28
#2Sara SeitunH-Index: 20
Last. Gianmario SambucetiH-Index: 48
view all 20 authors...
Background Recent technical advances in multi-detector computed tomography (MDCT) allow for assessment of coronary flow reserve (CFR). We compared regional CFR by dynamic SPECT and by dynamic MDCT in patients with suspected or known coronary artery disease (CAD).
9 CitationsSource