Mark N. Gaze
University College London Hospitals NHS Foundation Trust
Internal medicineRadiologySurgeryPathologyOncologyPediatricsMedical physicsAdverse effectExternal beam radiotherapyChemotherapyNeuroblastomaDiseaseRhabdomyosarcoma3-IodobenzylguanidineNuclear medicineIn patientCancer researchRadiation therapyClinical trialMedicineBiology
Publications 181
#6Ian Proctor (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 10
Abstract null null Background null Medullary thyroid carcinoma (MTC) in the context of multiple endocrine neoplasia type 2 (MEN2) is caused by mutations in the RET proto-oncogene. Therefore, in children with MEN2 and advanced MTC, the RET tyrosine kinase (TK) pathway is a target for treatment with selpercatinib, a selective RET TK inhibitor. null null null Patients and methods null A retrospective review of the clinical, genetic, biochemical (calcitonin and carcinoembryonic antigen [CEA]) and im...
#1Catherine A Taylor (UCLH: University College London Hospitals NHS Foundation Trust)
#2Ananth ShankarH-Index: 14
Last. Jamshed BomanjiH-Index: 51
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Peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues such as 177-lutetium DOTATATE is an effective treatment modality for neuroendocrine tumours, paragangliomas, and neuroblastomas. However, renal and haematopoietic toxicities are the major limitations of this therapeutic approach. The renal toxicity of PRRT is mediated by renal proximal tubular reabsorption and interstitial retention of the radiolabelled peptides resulting in excessive renal irradiation that c...
#1Tom Boterberg (Ghent University Hospital)H-Index: 33
#2Cathy Dunlea (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Mark N. Gaze (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 29
view all 7 authors...
#1Esther Bär (UCL: University College London)H-Index: 8
#2Charles-Antoine Collins-Fekete (UCL: University College London)H-Index: 6
Last. Gary Royle (UCL: University College London)H-Index: 22
view all 8 authors...
PURPOSE Relative stopping powers (RSP) for proton therapy are estimated using single-energy CT (SECT), calibrated with standardised tissues of the adult male. It is assumed that those tissues are representative of tissues of all age and sex. Female, male and paediatric tissues differ from one another in density and composition. In this study, we use tabulated paediatric tissues and computational phantoms to investigate the impact of this assumption on paediatric proton therapy. The potential of ...
#1Charlotte Atkinson (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
#2Balaji Ganeshan (UCL: University College London)H-Index: 34
Last. Mark N. Gaze (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 29
view all 8 authors...
Purpose Neuroendocrine tumours (NET) are rare cancers with variable behavior. A better understanding of prognosis would aid individualised management. The aim of this hypothesis-generating pilot study was to investigate the prognostic potential of tumour heterogeneity and tracer avidity in NET using texture analysis (TA) of 68Ga-DOTATATE positron emission tomography (PET) and non-enhanced computed tomography (CT) performed at baseline in patients treated with 177Lu-DOTATATE. It aims to justify a...
#2Pei Lim (UCLH: University College London Hospitals NHS Foundation Trust)
Last. C. VeigaH-Index: 10
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#1Alison Cameron (University Hospitals Bristol NHS Foundation Trust)H-Index: 8
#2Markus C. Elze (Hoffmann-La Roche)H-Index: 3
Last. Hélène MartelliH-Index: 26
view all 19 authors...
Abstract null null Purpose: There is limited evidence to define the role of radiotherapy in children with metastatic rhabdomyosarcoma (mRMS). In the international XXXX study, children with mRMS or non-RMS soft tissue sarcoma were randomized to receive standard chemotherapy with/without bevacizumab, with radiotherapy recommended to all disease sites after chemotherapy cycle 6. We retrospectively evaluated the impact of radiotherapy on survival in the mRMS cohort. null Methods and Materials: Patie...
#1Heidi Glosli (Oslo University Hospital)H-Index: 10
#2Gianni Bisogno (UNIPD: University of Padua)H-Index: 55
Last. EpSSG membersH-Index: 1
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Abstract Background/objectives The primary aim of this study was to analyse and evaluate the impact of different local treatments on the pattern of relapse in children with primary head and neck non-parameningeal (HNnPM) rhabdomyosarcoma (RMS), treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 study. The secondary aim was to assess whether current risk stratification is valid for this specific site. Design/methods This study includes all patients with localised H...
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