Rajendra S. Apte
Washington University in St. Louis
OphthalmologyInternal medicineSurgeryChemistryImmunologyMacular degenerationNeurodegenerationRetinaVisual acuityNeovascularizationDiseaseMacrophageDiabetic retinopathyAngiogenesisRetinalRetinal degenerationChoroidal neovascularizationCancer researchMedicineBiologyCell biology
173Publications
37H-index
4,693Citations
Publications 171
Newest
#1Raja NarayananH-Index: 3
view all 7 authors...
Source
#1Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
#2Christopher K. Hwang (WashU: Washington University in St. Louis)
Source
#1Bliss E. O’Bryhim (WashU: Washington University in St. Louis)H-Index: 1
#2Jonathan B. Lin (MEE: Massachusetts Eye and Ear Infirmary)
Last. Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
view all 4 authors...
Source
#1Jonathan B Lin (Harvard University)
#2Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
Source
#1Jonathan B. Lin (UW: University of Washington)
#2Arsham Sheybani (UW: University of Washington)
Last. Rajendra S. Apte (UW: University of Washington)H-Index: 37
view all 4 authors...
Purpose: Growth Differentiation Factor 15 (GDF15) was previously identified as a molecular marker of retinal ganglion cell stress in rodent models of glaucoma and was elevated in the aqueous humor (AH) of patients with primary open-angle glaucoma as a possible risk factor for glaucoma progression. The purpose of this study was to determine whether changes in the AH GDF15 levels were associated with intraocular pressure (IOP) changes in eyes undergoing glaucoma surgery. Methods: Here, we performe...
Source
#1Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
New Experimental Approach to Retinal Degeneration Loss of retinal photoreceptor cells is a critical event in loss of vision. A new, albeit tentative, strategy to rectify the loss of photoreceptor c...
Source
#1Jonathan J. Miner (WashU: Washington University in St. Louis)H-Index: 27
#2Derek J. Platt (WashU: Washington University in St. Louis)H-Index: 10
Last. Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
view all 12 authors...
Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmitted via corneal transplantation in mice. However, in human corneal explants, we report that ZIKV does not replicate efficiently and that SARS-CoV-2 does not replicate at all. Additionally, we demonstrate that type III interferon (IFN-λ) and its receptor (IFNλ...
6 CitationsSource
#1Yo Sasaki (WashU: Washington University in St. Louis)H-Index: 34
#2Hiroki Kakita (WashU: Washington University in St. Louis)H-Index: 1
Last. Jeffrey Milbrandt (WashU: Washington University in St. Louis)H-Index: 120
view all 13 authors...
Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by mutations of the NAD+ synthesis enzyme NMNAT1. Despite the ubiquitous expression of NMNAT1, patients do not manifest pathologies other than retinal degeneration. Here we demonstrate that widespread NMNAT1 depletion in adult mice mirrors the human pathology, with selective loss of photoreceptors highlighting the exquisite vulnerability of these cells to NMNAT1 loss. Conditional deletion demonstrates that NMNAT1 i...
8 CitationsSource
#1Cecilia S. Lee (UW: University of Washington)H-Index: 21
#2Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
PURPOSE: To address challenges associated with identifying retinal biomarkers for Alzheimer'sdisease (AD) and strategies for future investigation of novel ophthalmologic biomarkers. DESIGN: Perspective METHODS: Summarization of the current understanding of retinal changes that have been identified using advances in imaging technology, analysis of current research into how these changes reflect neurodegenerative pathology, and recommendations for further research in this area that will allow for ...
5 CitationsSource
#1Aaditya Shah (WashU: Washington University in St. Louis)H-Index: 1
#2Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of intraocular tissues with high resolution. Recently, an innovative use of this technology in studying neurodegenerative diseases has emerged with the neurosensory retina as a unique window into deeper brain tissues. Here, we discuss its role in identifying biomarkers of neurodegenerative diseases.
1 CitationsSource