Tiziana Rancati
University of Milan
CancerInternal medicineRadiologyUrologySurgeryOncologyProspective cohort studyCohort studyProstateAbdominal surgeryProstate cancerRectumPopulationToxicityNuclear medicineIn patientRadiation therapyBreast cancerMedicineCohortUrinary systemGastroenterology
Publications 300
#1Federica PaloriniH-Index: 9
Last. Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 55
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Purpose Development of NTCP models of late severe urinary symptoms after radical RT for prostate cancer (PCa). Methods Patients were enrolled in a prospective, multicentre, observational trial in 2010–2014 and treated with conventional (74–80 Gy at 1.8–2 Gy/fr) or moderately hypofractionated IMRT (65–75.2 Gy at 2.2–2.7 Gy/fr). Bladder dose-surface histograms were corrected to 2 Gy/fr equivalent doses (EQD2) and reduced to Equivalent Uniform Doses at varying α / β and n. Urethral stricture requir...
#2Tiziana RancatiH-Index: 27
Last. Riccardo Valdagni (University of Milan)H-Index: 50
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Purpose To develop a modelling procedure for late rectal bleeding (LRB) that goes beyond maximum likelihood model fitting of data. Thus, to create a metamodel for grade 2–3 (G23) and grade 3 (G3) LRB starting from literature evidence and validate it on a large population. Methods Metamodelling allows to highlight specific features of the model itself. Characteristics that predictive models for LRB have in common are: the global harmony of radiobiological parameters (volume effect parameter, n, s...
#1Ester OrlandiH-Index: 23
Last. Anna CavalloH-Index: 7
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Abstract Introduction/objective Oral and oropharyngeal mucositis (OM) represents a multifactorial and complex interplay of patient-, tumor-, and treatment-related factors. We aimed to build a predictive model for acute OM for locally advanced nasopharyngeal carcinoma (NPC) patients by combining clinical and dosimetric factors. Materials/methods A series of consecutive NPC patients treated curatively with IMRT/VMAT + chemotherapy at 70 Gy (2–2.12 Gy/fr) was considered. For each patient, clinical-...
10 CitationsSource
#1Alessandro Cicchetti (UNIPV: University of Pavia)H-Index: 7
#2Barbara AvuzziH-Index: 10
Last. Riccardo Valdagni (University of Milan)H-Index: 50
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Purpose This study aimed to validate a previously published predictive model for late fecal incontinence (FI) in a contemporary population of prostate cancer patients treated with radical radiation therapy. Methods and Materials The validation included patients treated with intensity-modulated radiation therapy (IMRT) (2010-2014). Prescribed dose range was 65-80 Gy, including conventional and moderate hypo-fractionated treatments. Rectal toxicity was scored using LENT/SOMA, a minimum 2-year foll...
7 CitationsSource
#1Paolo GandelliniH-Index: 25
#2Rihan El BezawyH-Index: 3
Last. Nadia ZaffaroniH-Index: 66
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Radiotherapy is a standard treatment for organ-confined prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a significant percentage of patients still undergo recurrence. The onset of radioresistance is a complex phenomenon involving several genetic and epigenetic abnormalities, including the deregulation of microRNAs (miRNAs), endogenous small noncoding RNA molecules that negatively regulate gene expression. In this study, we investigated t...
#1John Kang (URMC: University of Rochester Medical Center)H-Index: 7
#2Tiziana RancatiH-Index: 27
Last. Barry S. Rosenstein (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
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Due to the rapid increase in the availability of patient data, there is significant interest in precision medicine that could facilitate the development of a personalized treatment plan for each patient on an individual basis. Radiation oncology is particularly suited for predictive machine learning models due to the enormous amount of diagnostic data used as input and therapeutic data generated as output. An emerging field in precision radiation oncology that can take advantage of machine learn...
32 CitationsSource
#2Claudia RepettoH-Index: 17
Last. Lara BellarditaH-Index: 10
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Purpose:The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) is a self-report questionnaire that was developed in English to assess prostate cancer (PCa)-related anxiety. The aim of this study w...
3 CitationsSource
#1Tiziana RancatiH-Index: 27
#2C. FiorinoH-Index: 7