Gianni Fellin
Acute toxicityCancerInternal medicineRadiologyUrologySurgeryOncologyOdds ratioProspective cohort studyCystectomySurvival rateChemotherapyProstate cancerBladder cancerRectumCombined Modality TherapyToxicityNuclear medicineRadiation therapyMedicineGastroenterology
Publications 32
#2Tiziana RancatiH-Index: 27
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 13 authors...
Abstract Aim To investigate late gastrointestinal toxicity in a large pooled population of prostate cancer patients treated with radical radiotherapy. Normal tissue complication probability models were developed for late stool frequency and late rectal pain. Methods and materials Population included 1336 patients, 3-year minimum follow-up, treated with 66–80 Gy. Toxicity was scored with LENT-SOMA-scale. Two toxicity endpoints were considered: grade ⩾2 rectal pain and mean grade (average score du...
12 CitationsSource
#1Orazio CaffoH-Index: 36
#2C. Thompson (University of Manchester)H-Index: 2
Last. Ananya Choudhury (University of Manchester)H-Index: 28
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Abstract Purpose Although radical cystectomy is still considered the standard of care for most localized muscle-invasive bladder cancer (MIBC) patients, bladder-sparing strategies with chemoradiotherapy have demonstrated comparable local control and survival rates when adjusting for tumor stage. We present a pooled analysis of individual patient data out of published trials with gemcitabine-based chemoradiotherapy for MIBC. Methods and materials Individual patient data were collected from Instit...
24 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. Riccardo ValdagniH-Index: 51
view all 10 authors...
#1Gianni FellinH-Index: 17
#2Tiziana Rancati (UniSR: Vita-Salute San Raffaele University)H-Index: 27
Last. Riccardo Valdagni (UniSR: Vita-Salute San Raffaele University)H-Index: 51
view all 18 authors...
Abstract Purpose To prospectively evaluate long-term late rectal bleeding (lrb) and faecal incontinence (linc) after high-dose radiotherapy (RT) for prostate cancer in the AIROPROS 0102 population, and to assess clinical/dosimetric risk factors. Materials and methods Questionnaires of 515 patients with G0 baseline incontinence and bleeding scores (follow-up ⩾6years) were analysed. Correlations between lrb/linc and many clinical and dosimetric parameters were investigated by univariate and multiv...
26 CitationsSource
Although radical cystectomy is still the treatment of choice for patients with infiltrating bladder cancer, there is growing evidence of the effectiveness of a conservative approach. Developed as a treatment of need for elderly or unfit patients unable to undergo radical cystectomy, conservative therapy is becoming a true alternative to surgery for highly selected patients. Although transurethral bladder resection, external radiotherapy and systemic chemotherapy can control the disease as single...
15 CitationsSource
#1Orazio CaffoH-Index: 36
#2Antonello VecciaH-Index: 14
Last. Enzo GalligioniH-Index: 25
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It has recently been reported that the incidence of brain metastases (BMs) from prostate cancer (PC) has increased in comparison with historical series. The aim of this study was to compare the incidence of BMs in the pre- and post-docetaxel era in a single institution in which all oncological patients are referred to one Radiotherapy and one Medical Oncology Department. We searched the electronic databases of these departments for all males with BMs entered from 1994 to 2011. The year of the in...
16 CitationsSource
#1Riccardo ValdagniH-Index: 51
#2Vittorio VavassoriH-Index: 18
Last. C. Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 7
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Purpose: To evaluate and discuss the role of specific types of abdominal surgery (SURG) before radical radiation therapy as a risk factor for late rectal toxicity in prostate cancer patients. Methods: Results concerning questionnaire-based scored late bleeding and faecal incontinence in 718 patients with a complete follow-up of 36 months were analysed, focusing on the impact of specific pre-radiotherapy abdominal/pelvic surgery procedures. Patients were accrued in the prospective study AIROPROS ...
30 CitationsSource
Purpose To model late fecal incontinence after high-dose prostate cancer radiotherapy (RT) in patients accrued in the AIROPROS (prostate working group of the Italian Association of Radiation Oncology) 0102 trial using different endpoint definitions. Methods and Materials The self-reported questionnaires (before RT, 1 month after RT, and every 6 months for ≤3 years after RT) of 586 patients were available. The peak incontinence (P_INC) and two longitudinal definitions (chronic incontinence [C_INC...
29 CitationsSource
#1Lucia PernaH-Index: 17
#2Cesare CozzariniH-Index: 43
Last. C. FiorinoH-Index: 7
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Several investigations have recently suggested the existence of a correlation between the dose received by the penile bulb (PB) and the risk of erectile dysfunction (ED) after radical radiotherapy for clinically localized prostate carcinoma. A prospective multi-Institute study (DUE-01) was implemented with the aim to assess the predictive parameters of ED. Previously, an evaluation of inter-observer variations of PB contouring was mandatory in order to quantify its impact on PB dose-volume param...
20 CitationsSource
#1Tiziana RancatiH-Index: 27
#2C. FiorinoH-Index: 7
Last. Riccardo ValdagniH-Index: 51
view all 12 authors...
Abstract Background and purpose To fit an NTCP model including clinical risk factors to late rectal toxicities after radiotherapy for prostate cancer. Methods and materials Data of 669 patients were considered. The probability of late toxicity within 36months (bleeding and incontinence) was fitted with the original and a modified Logit-EUD model, including clinical factors by fitting a subset specific TD 50 s: the ratio of TD 50 s with and without including the clinical variable was the dose-mod...
52 CitationsSource