Patrizia Giannatempo
University of Milan
Internal medicineSurgeryOncologyStage (cooking)Clinical endpointCystectomyChemotherapyGerm cell tumorsCarcinomaCisplatinPembrolizumabBladder cancerSalvage therapyMetastatic Urothelial CarcinomaMuscle invasiveIn patientOpen labelPhases of clinical researchProportional hazards modelMedicine
Publications 267
#1Filippo PederzoliH-Index: 13
#2Irene LocatelliH-Index: 7
Last. Dejan LazarevicH-Index: 24
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Abstract Background Data regarding the role of positron emission tomography/computed tomography (PET/CT) to stage lymph nodes in patients receiving neoadjuvant immunotherapy before radical cystectomy are lacking. The aim of this study is to evaluate the role of PET/CT to predict the pathologic lymph node involvement (LNI) in patients with MIBC receiving neoadjuvant pembrolizumab within the PURE-01 trial (NCT02736266). Material and methods Three courses of pembrolizumab were administered before r...
2 CitationsSource
#1Christoph Seidel (UHH: University of Hamburg)H-Index: 18
#2Gedske Daugaard (Copenhagen University Hospital)H-Index: 60
Last. Christoph Oing (UHH: University of Hamburg)H-Index: 15
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PURPOSE The prognostic significance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defined. We investigated the prognostic impact of LDH levels prior to first-line systemic treatment and other clinical characteristics in this subset of patients. METHODS Files from two registry studies and one single-institution database were analyzed retrospectively. Uni- and multivariate analyses were conducted to identify patient characteristics associated with recurrence free survi...
1 CitationsSource
#2Laura Marandino (UNITO: University of Turin)H-Index: 10
Last. Massimo Di Maio (UNITO: University of Turin)H-Index: 47
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401Background: Considerable numbers of patients (pts) with metastatic urothelial carcinoma (mUC) (approximately 25-47%) develop bone metastases (BoM). Their impact on the efficacy of immunotherapy ...
#1Laura MarandinoH-Index: 10
#2Russell Madison (Foundation Medicine)H-Index: 12
Last. Andrea NecchiH-Index: 35
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479Background: MIBC is an aggressive disease and a limited number of patients (pts) will benefit from neoadjuvant chemotherapy (NAC) or immunotherapy. CGP may help identify prognostic factors, pred...
#1Daniele RaggiH-Index: 19
#2Marco Bandini (UniSR: Vita-Salute San Raffaele University)H-Index: 24
Last. Andrea NecchiH-Index: 35
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449Background: Administration of single-agent neoadjuvant immunotherapy (IO) proved to be effective and safe in the treatment of MIBC, and the identification of reliable predictors of treatment-fai...
#1Melissa Bersanelli (University of Parma)H-Index: 19
#2Sebastiano Buti (University of Parma)H-Index: 24
Last. Fausto PetrelliH-Index: 45
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Abstract Background Advanced upper tract urothelial carcinoma (UTUC) has different molecular and genetic features from the commonest carcinoma of the bladder, suggesting a possible different sensitivity to immune-checkpoint inhibitors (ICI). Methods A systematic review and meta-analysis of all relevant clinical studies including advanced UTUC patients treated with ICI was conducted according to PRISMA guidelines. Results Six prospective trials for a total 2537 patients, including 396 (15.6%) wit...
1 CitationsSource