Yoshiko Ishimi
Showa University
EndocrinologyBone remodelingChemistryOsteoclastOsteoporosisBone mineralEstrogenOsteoblastGenisteinBone densityIsoflavonesBone marrowDaidzeinEquolFood scienceBiochemistryBone resorptionMedicineOvariectomized ratBiology
114Publications
32H-index
4,164Citations
Publications 114
Newest
#1Yu Matsumoto (Tokyo University of Agriculture)H-Index: 3
#2Yoshiko IshimiH-Index: 32
Last. Yuji Yamamoto (Tokyo University of Agriculture)H-Index: 13
view all 6 authors...
Abstract Soybeans are a complete nutritional resource and soybean proteins are known to affect lipid metabolism via multiple mechanisms. Soybean meal (SBM) is produced after extraction of soybean oil and in this study we investigated the ability whether the SBM could prevent high fat diet-induced obesity and understand the underlying mechanisms. Male Sprague–Dawley rats, aged 5 weeks, were randomly divided into 3 groups (n=8 each) and fed one of three diets for 28 days: Cont (AIN-93G), HFD (high...
1 CitationsSource
#1Kaoru Yanaka (Waseda University)H-Index: 2
#2Mitsuru Higuchi (Waseda University)H-Index: 37
Last. Yoshiko IshimiH-Index: 32
view all 3 authors...
: Female athlete triad (FAT) is an interrelationship between menstrual dysfunction, low energy availability with or without eating disorder, and decreased bone mineral density (BMD) in female athletes. The purpose of this study was to investigate whether isoflavone intake can prevent bone loss caused by voluntary wheel running under energy-restricted condition. We used a female rat model of osteoporosis for female athletes established previously. Fourteen female Sprague-Dawley rats (8-wk old) we...
2 CitationsSource
: To clarify the degree of consistency between the international recommendations and the national Japanese system, the nutrient reference values (NRVs) adopted by the CODEX were compared with current Japanese NRVs 2015, the dietary reference intakes for Japanese (DRIs-J) 2015, and actual nutrient intake levels by the Japanese population. The Japanese NRV for protein was high relative to CODEX NRV-R (i.e., NRV-Requirement). The Japanese NRVs for folate and calcium were low, and vitamin K was high...
1 CitationsSource
#1Yuko TousenH-Index: 10
#2Yu MatsumotoH-Index: 3
Last. Yoshiko IshimiH-Index: 32
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The intestinal microbiota may regulate bone metabolism by reducing levels of pro-inflammatory cytokines, and T cells in bone tissues of oestrogen-deficient mice have been reported. Resistant starch (RS) is a type of dietary fibre and results in changes in the composition of the gut microbiota. We evaluated the effects of RS supplemented in diets on intestinal microbial composition, bone mineral density, and inflammatory-gene expression in the colon and bone marrow of ovariectomised (OVX) mice. O...
11 CitationsSource
#1Jun Yamauchi (Tokyo University of Agriculture)H-Index: 7
#2Sarasa Kogure (Tokyo University of Agriculture)H-Index: 1
Last. Yoshiko IshimiH-Index: 32
view all 9 authors...
1 CitationsSource
Source
#1Yoshiko IshimiH-Index: 32
#2J TakebayashiH-Index: 1
Last. Nobuo KawaharaH-Index: 27
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Abstract Focusing on licorice, a highly used raw material in health foods, quantitative analysis of functional/medicinal components and a safety and functional evaluation was carried out for herbal medicines, health food ingredients, and so-called health foods. A functional component, glabridin, was detected in herbal medicines from Glycyrrhiza glabra and G. inflata, health food ingredients, and in commercially available health foods that contain licorice. Likewise, glycyrrhizin, a medicinal com...
1 CitationsSource
#1Yu Matsumoto (Tokyo University of Agriculture)H-Index: 3
#2Yuko TousenH-Index: 10
Last. Yoshiko IshimiH-Index: 32
view all 3 authors...
: β-Carotene has been reported to be useful to maintain a positive balance of bone turnover. However, the effects of β-carotene on bone loss remain to be elucidated in mice with hind limb unloading. Therefore, we investigated whether β-carotene prevented bone loss induced by skeletal hind limb unloading in mice. Female 8-week-old ddY mice were divided into six groups (n = 6-8 each) and subjected to: (1) normal housing, (2) sham unloading fed a control diet, (3) hind limb unloading fed a control ...
3 CitationsSource
#1Mako Tsuji (Ibaraki University)H-Index: 1
#2Tomoki Tanaka (Ibaraki University)H-Index: 1
Last. Yukio Ishimi (Ibaraki University)H-Index: 23
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: It has been reported that daidzein and equol stimulate DNA replication and proliferation of MCF-7 cells. However, their molecular mechanisms of action are still unclear. We examined the effects of daidzein and equol on DNA replication of MCF-7 cells, focusing on MCM2-7 proteins, which function as the replicative helicase. In the presence of either 1 μM of daidzein or equol, the number of cells in S-phase, which was determined by detecting bromodeoxyuridine incorporated into replicated DNA, alm...
3 CitationsSource
Background and Objectives: Isoflavone (daidzein and genistein) interventions in postmenopausal women have produced inconsistent skeletal benefits, partly due to population heterogeneity in daidzein metabolism to equol by enteric bacteria. This study assessed changes in microflora and bone turnover in response to isoflavone and kiwifruit supplementation in New Zealand postmenopausal women. Methods and Study Design: Healthy women 1-10 years post-menopause were randomly allocated to group A (n=16) ...
5 CitationsSource
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