Paula Cunnea
Imperial College London
CancerInternal medicinePhenotypePathologyOncologySerous fluidStromal cellGene knockdownGenome instabilityLymphatic systemChemotherapyCisplatinDiseaseOvarian tumorOvarian cancerDebulkingSerous ovarian cancerPoor prognosisCancer researchCarcinogenesisBioinformaticsMedicineBiomarker (medicine)Protein kinase BEpithelial–mesenchymal transitionPI3K/AKT/mTOR pathwayBiology
35Publications
7H-index
201Citations
Publications 35
Newest
#1Paula CunneaH-Index: 7
#2Christina Fotopoulou (Imperial College London)H-Index: 20
Last. M Kessler (LMU: Ludwig Maximilian University of Munich)
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Gynaecological malignancies represent a heterogeneous group of neoplasms with vastly different aetiology, risk factors, molecular drivers, and disease outcomes. From HPV-driven cervical cancer where early screening and molecular diagnostics efficiently reduced the number of advanced-stage diagnosis, prevalent and relatively well-treated endometrial cancers, to highly aggressive and mostly lethal high-grade serous ovarian cancer, malignancies of the female genital tract have unique presentations ...
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Last. Paula CunneaH-Index: 7
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1 CitationsSource
#1T Bartl (Medical University of Vienna)H-Index: 3
#2Jasmine KaracsH-Index: 1
Last. Grimm ChristophH-Index: 1
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This study aimed to assess the predictive value of tumor growth rate estimates based on serial cancer antigen-125 (CA-125) levels on therapy response and survival of patients with recurrent high-grade serous ovarian cancer (HGSOC). In total, 301 consecutive patients with advanced HGSOC (exploratory cohort: n = 155, treated at the Medical University of Vienna; external validation cohort: n = 146, from the Ovarian Cancer Therapy–Innovative Models Prolong Survival (OCTIPS) consortium) were enrolled...
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#1Manikandan Periyasamy (Imperial College London)H-Index: 16
#2Anup Kumar Singh (Imperial College London)H-Index: 7
Last. Simak Ali (Imperial College London)H-Index: 57
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The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing A3B levels, and consequently limiting cancer mutagenesis. We previously demonstrated that A3B is repressed by p53 and p53 mutation increases A3B expression. Here, we investigate A3B expression upon treatment wi...
1 CitationsSource
#1Haonan Lu (Imperial College London)H-Index: 7
#2Paula Cunnea (Imperial College London)H-Index: 7
Last. Christina Fotopoulou (Imperial College London)H-Index: 20
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BACKGROUND Maximal effort cytoreductive surgery is associated with improved outcomes in advanced high-grade serous ovarian cancer (HGSOC). However, despite complete gross resection (CGR), there is a percentage of patients who will relapse and die early. The aim of this study is to identify potential candidate biomarkers to help personalise surgical radicality. METHODS 136 advanced HGSOC cases who underwent CGR were identified from three public transcriptomic datasets. Candidate prognostic biomar...
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#1Zhiyuan Hu (University of Oxford)H-Index: 4
#2Paula Cunnea (Imperial College London)H-Index: 7
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
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Purpose: Using RNA sequencing, we recently developed the 52-gene–based Oxford classifier of carcinoma of the ovary (Oxford Classic, OxC) for molecular stratification of serous ovarian cancers (SOCs) based on the molecular profiles of their cell of origin in the fallopian tube epithelium. Here, we developed a 52-gene NanoString panel for the OxC to test the robustness of the classifier. Experimental Design: We measured the expression of the 52 genes in an independent cohort of prospectively colle...
1 CitationsSource
#1Jennifer PloskiH-Index: 2
#2Katherine NixonH-Index: 5
Last. Christina FotopoulouH-Index: 30
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Introduction/Background High-grade serous ovarian cancer (HGSOC) is the most common subtype of ovarian cancer, characterised by vast genomic instability and heterogeneity and acquired resistance to platinum-based chemotherapy. However, matching the most beneficial treatment options to patients is difficult to predict due to different platinum resistance mechanisms and limited effective predictive biomarkers. A study characterising intra-tumoural heterogeneity in HGSOC has identified variations i...
1 CitationsSource
#1Paula CunneaH-Index: 7
#2Edward CurryH-Index: 15
Last. Christina FotopoulouH-Index: 20
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Introduction/Background High-grade serous ovarian cancer (HGSOC) is characterised by high degrees of genomic instability and heterogeneity, with most patients eventually acquiring resistance to platinum-based chemotherapy. Matching the best treatment options to patients remains problematic due to diverse platinum resistance mechanisms and limited effective predictive biomarkers. This study aims to understand the extent of intra-tumoural heterogeneity (ITH) in advanced stage HGSOC, at presentatio...
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#1Sarah Christina Johnson (Imperial College London)H-Index: 1
#2Sanjukta Chakraborty (A&M: Texas A&M University)H-Index: 17
Last. James E. Moore (Imperial College London)H-Index: 45
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Lymphogenic spread is associated with poor prognosis in epithelial ovarian cancer (EOC), yet little is known regarding roles of non-peri-tumoural lymphatic vessels (LVs) outside the tumour microenvironment that may impact relapse. The aim of this feasibility study was to assess whether inflammatory status of the LVs and/or changes in the miRNA profile of the LVs have potential prognostic and predictive value for overall outcome and risk of relapse. Samples of macroscopically normal human lymph L...
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#1Paula CunneaH-Index: 7
#2Edward CurryH-Index: 15
Last. Christina FotopoulouH-Index: 30
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