Kathie A. Mihindukulasuriya
Washington University in St. Louis
GeneGenomeMicrobiomeGene expressionMetagenomicsMolecular biologyOmicsVirologyNeurosciencePhosphataseCell typeHuman Microbiome ProjectVirusDiseaseMicrogliaCerebral cortexAlzheimer's diseaseGeneticsComputational biologyEvolutionary biologyBiologyPhylogeneticsHuman microbiome
43Publications
20H-index
9,585Citations
Publications 41
Newest
#1Kathie A. Mihindukulasuriya (WashU: Washington University in St. Louis)H-Index: 20
#2Lindsay Droit (WashU: Washington University in St. Louis)H-Index: 16
Last. David Wang (WashU: Washington University in St. Louis)H-Index: 57
view all 8 authors...
We report the draft genome sequences of five novel members of the family Picornaviridae that were isolated from the stool of rhesus macaques (Macaca mulatta) with chronic diarrhea. The strains were named NOLA-1 through NOLA-5 because the macaques were residents of the Tulane National Primate Research Center.
Source
#1Chengran Yang (WashU: Washington University in St. Louis)H-Index: 5
#2Fabiana H.G. Farias (WashU: Washington University in St. Louis)H-Index: 8
Last. Jorge A. Bahena (WashU: Washington University in St. Louis)H-Index: 2
view all 22 authors...
Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic atlas of protein levels in three tissues relevant to neurological disorders (brain, cerebrospinal fluid and plasma) by profiling thousands of proteins from participants with and without Alzheimer's disease. We identified 274, 127 and 32 protein quantitative trait loci (pQTLs) for cerebrospinal fluid, plasma and brai...
3 CitationsSource
#1Kathie A. Mihindukulasuriya (WashU: Washington University in St. Louis)H-Index: 20
#2Ruben A. T. Mars (Mayo Clinic)H-Index: 9
Last. Ran Blekhman (UMN: University of Minnesota)H-Index: 33
view all 15 authors...
Background & Aims null The gut virome includes eukaryotic viruses and bacteriophages that can shape the gut bacterial community and elicit host responses. The virome can be implicated in diseases, such as irritable bowel syndrome (IBS), where gut bacteria play an important role in pathogenesis. We provide a comprehensive and longitudinal characterization of the virome, including DNA and RNA viruses and paired multi-omics data in a cohort of healthy subjects and patients with IBS. null Methods nu...
1 CitationsSource
#1Erin R. Saito (BYU: Brigham Young University)H-Index: 2
#2Justin B. Miller (BYU: Brigham Young University)H-Index: 14
Last. Benjamin T. Bikman (BYU: Brigham Young University)H-Index: 19
view all 7 authors...
Introduction Sporadic Alzheimer's disease (AD) is strongly correlated with impaired brain glucose metabolism, which may affect AD onset and progression. Ketolysis has been suggested as an alternative pathway to fuel the brain. Methods RNA-seq profiles of post mortem AD brains were used to determine whether dysfunctional AD brain metabolism can be determined by impairments in glycolytic and ketolytic gene expression. Data were obtained from the Knight Alzheimer's Disease Research Center (62 cases...
3 CitationsSource
#1Jorge A. Bahena (WashU: Washington University in St. Louis)H-Index: 2
#2Brett Eiffert (WashU: Washington University in St. Louis)H-Index: 1
Last. Oscar Harari (WashU: Washington University in St. Louis)H-Index: 23
view all 8 authors...
Source
#1Shih‐Feng You (WashU: Washington University in St. Louis)
#2June He (WashU: Washington University in St. Louis)
Last. Celeste M. Karch (WashU: Washington University in St. Louis)H-Index: 36
view all 10 authors...
Source
#1Chengran Yang (WashU: Washington University in St. Louis)H-Index: 5
Last. Oscar Harari (WashU: Washington University in St. Louis)H-Index: 23
view all 9 authors...
Source
#2Chengran Yang (WashU: Washington University in St. Louis)H-Index: 5
#3Fabiana H.G. Farias (WashU: Washington University in St. Louis)H-Index: 8
Last. Fengxian Wang (WashU: Washington University in St. Louis)H-Index: 4
view all 21 authors...
Expression quantitative trait loci (eQTL) mapping has successfully resolved some genome-wide association study (GWAS) loci for complex traits. However, there is a need for implementing additional "omic" approaches to untangle additional loci and provide a biological context for GWAS signals. We generated a detailed landscape of the genomic architecture of protein levels in multiple neurologically relevant tissues (brain, cerebrospinal fluid (CSF) and plasma), by profiling thousands of proteins i...
4 CitationsSource
#1Francesca Cignarella (WashU: Washington University in St. Louis)H-Index: 7
#2Fabia Filipello (WashU: Washington University in St. Louis)H-Index: 9
Last. Laura Piccio (USYD: University of Sydney)H-Index: 38
view all 20 authors...
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2 is expressed by microglia and promotes microglial survival, proliferation, and phagocytic activity. Herein we demonstrate that TREM2 was highly expressed on myelin-laden phagocytes in active demyelinating lesions ...
35 CitationsSource
#1Bruce A. Rosa (WashU: Washington University in St. Louis)H-Index: 3
#2Kathie A. Mihindukulasuriya (WashU: Washington University in St. Louis)H-Index: 20
Last. Makedonka Mitreva (WashU: Washington University in St. Louis)H-Index: 59
view all 10 authors...
ABSTRACT Whole-genome bacterial sequences are required to better understand microbial functions, niche-specific bacterial metabolism, and disease states. Although genomic sequences are available for many of the human-associated bacteria from commonly tested body habitats (e.g., feces), as few as 13% of bacterium-derived reads from other sites such as the skin map to known bacterial genomes. To facilitate a better characterization of metagenomic shotgun reads from underrepresented body sites, we ...
1 CitationsSource