Virend K. Somers
Mayo Clinic
Sleep in non-human animalsInternal medicineEndocrinologyCardiologyObstructive sleep apneaSleep apneaHeart rateHeart failurePolysomnographyAtrial fibrillationContinuous positive airway pressureCentral sleep apneaBody mass indexPopulationIn patientAnesthesiaObesityMedicineBlood pressure
Publications 747
#1Joshua M. Bock (Mayo Clinic)H-Index: 1
#2Soumya Vungarala (Mayo Clinic)H-Index: 1
Last. Virend K. Somers (Mayo Clinic)H-Index: 117
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While the contribution of several physiological systems to arterial blood pressure regulation has been studied extensively, the role of normal and disrupted sleep as a modifiable determinant of blood pressure control, and in the pathophysiology of hypertension, has only recently emerged. Several sleep disorders, including sleep apnea and insomnia, are thought to contribute to the development of hypertension, although less attention is paid to the relationship between sleep duration and blood pre...
#1Emerson M. Wickwire (UMB: University of Maryland, Baltimore)H-Index: 19
#2M. Doyinsola Bailey (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Jennifer S. Albrecht (UMB: University of Maryland, Baltimore)H-Index: 19
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To examine (1) the impact of adherence to continuous positive airway pressure (CPAP) therapy on risk for cardiovascular (CVD) events among a nationally representative sample of older adults with obstructive sleep apnea (OSA), and (2) the heterogeneity of this effect across subgroups defined by race, sex, and socioeconomic status. We conducted a retrospective cohort study among Medicare beneficiaries aged ≥ 65 years with OSA (2009–2013). Monthly indicators of CPAP adherence (charges for machines,...
#1Jingen Li (Mayo Clinic)H-Index: 1
#2Virend K. Somers (Mayo Clinic)H-Index: 117
Last. Naima Covassin (Mayo Clinic)H-Index: 14
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BACKGROUND Rest-activity rhythm (RAR), a manifestation of circadian rhythms, has been associated with morbidity and mortality risk. However, RAR patterns in the general population and specifically the role of demographic characteristics in RAR pattern have not been comprehensively assessed. Therefore, we aimed to describe RAR patterns among non-institutionalized US adults and age, sex, and race/ethnicity variation using accelerometry data from a nationally representative population. METHODS This...
#1Emelia J. Benjamin (BU: Boston University)H-Index: 54
#2Sana M. Al-Khatib (Duke University)H-Index: 76
Last. Paulus KirchhofH-Index: 108
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There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevale...
#1Martin R. CowieH-Index: 84
#2Dominik Linz (Maastricht University Medical Centre)H-Index: 37
Last. Anita K. Simonds (Twitter)
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Abstract null null Sleep disordered breathing causes repetitive episodes of nocturnal hypoxemia, sympathetic nervous activation, and cortical arousal, often associated with excessive daytime sleepiness. Sleep disordered breathing is common in people with, or at risk of, cardiovascular (CV) disease including those who are obese or have hypertension, coronary disease, heart failure, or atrial fibrillation. Current therapy of obstructive sleep apnea includes weight loss (if obese), exercise, and po...
1 CitationsSource
#1Yerem YeghiazariansH-Index: 45
#2Hani JneidH-Index: 34
Last. Virend K. SomersH-Index: 117
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Obstructive sleep apnea (OSA) is characterized by recurrent complete and partial upper airway obstructive events, resulting in intermittent hypoxemia, autonomic fluctuation, and sleep fragmentation. Approximately 34% and 17% of middle-aged men and women, respectively, meet the diagnostic criteria for OSA. Sleep disturbances are common and underdiagnosed among middle-aged and older adults, and the prevalence varies by race/ethnicity, sex, and obesity status. OSA prevalence is as high as 40% to 80...
1 CitationsSource
#1Naima Covassin (Mayo Clinic)H-Index: 14
#2Jan Bukartyk (Mayo Clinic)H-Index: 11
Last. Virend K. Somers (Mayo Clinic)H-Index: 117
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Although insufficient sleep is associated with increased cardiovascular risk, evidence of a causal relationship is lacking. We investigated the effects of prolonged sleep restriction on 24-hour ambulatory blood pressure (BP) and other cardiovascular measures in 20 healthy young participants (aged 23.4±4.8 years, 9 females), who underwent a randomized, controlled, crossover, 16-day inpatient study consisting of 4 days of acclimation, 9 days of sleep restriction (4 hours of sleep/night) or control...
#1Jingen Li (Mayo Clinic)H-Index: 1
#2Naima Covassin (Mayo Clinic)H-Index: 14
Last. Virend K. Somers (Mayo Clinic)H-Index: 117
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Purpose Excessive daytime sleepiness is highly prevalent and has been associated with increased risk of cardiovascular diseases, but evidence for its association with cardiovascular mortality is limited and inconsistent. We aimed to determine whether excessive daytime sleepiness is independently associated with cardiovascular mortality in general adult population. Patients and Methods A prospective study of 10,330 adult participants (aged ≥20 years) from National Health and Nutrition Examination...
#1Hao Cui (Mayo Clinic)H-Index: 4
#2Hartzell V. Schaff (Mayo Clinic)H-Index: 131
Last. Steve R. Ommen (Mayo Clinic)H-Index: 78
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Abstract null null Objective null To determine the impact of sleep-disordered breathing (SDB) on survival in patients with hypertrophic cardiomyopathy (HCM) following septal myectomy. null null null Patients and Methods null Patients with obstructive HCM undergoing septal myectomy from 2007 to 2016 were reviewed. Those who had an overnight oximetry test within 6 months before myectomy were included in analysis. Oxygen desaturation index was examined continuously and also categorically (SDB [>5/h...
1 CitationsSource
#1Rodrigo IturriagaH-Index: 32
#2Julio AlcayagaH-Index: 19
Last. Virend K. SomersH-Index: 117
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The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2 and CO2, and pH, eliciting reflex ventilatory, cardiovascular and humoral responses to maintain homeostasis. This review examines the fundamental biology underlying CB chemoreceptor function, its contribution to integrated physiologic responses, and its role in maintaining health and potentiating disease. Emphasis will be placed on: i) Transduction mechanisms in chemoreceptor (type I) cells, highlighting...
2 CitationsSource