Frank Birklein
University of Mainz
PathophysiologyEndocrinologyNociceptionPsychologyNeurologyNeurosciencePhysical therapyStimulationNeurogenic inflammationSympathetic nervous systemNeuropathic painAllodyniaSudomotorAxon reflexHyperalgesiaComplex regional pain syndromeChronic painAnesthesiaMedicineSensory system
Publications 325
#1Ana Luiza C. Sayegh (University of Auckland)H-Index: 1
#2Annette Janzen (University of Marburg)H-Index: 5
Last. Christoph Best (University of Marburg)H-Index: 4
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Abstract Objective Changes in baroreflex sensitivity have been reported in patients with idiopathic Parkinson’s disease (PD). We sought to investigate the hypothesis that patients with isolated rapid eye movement (REM)-sleep behavior disorder (iRBD), known to be a prodromal stage for PD, will show abnormalities in baroreflex control. Methods Ten iRBD patients were compared to 10 sex- and age-matched healthy controls. Their cardiovascular parameters and muscle sympathetic nerve activity (MSNA) we...
Diabetic neuropathy (dNP) patients often suffer from severe neuropathic pain. It was suggested that alpha-1 adrenoceptor (α1-AR) hyperresponsiveness contributes to pain in dNP. The aim of our study was to quantify α1-AR expression using immunohistochemistry in skin biopsies of nine patients with painful diabetic neuropathy compared to 10 healthy controls. Additionally, the association between α1-AR expression and activation with spontaneous and sympathetically maintained pain (SMP) induced by in...
#1Xiaoyou ShiH-Index: 25
#2Tian-Zhi GuoH-Index: 28
Last. Wade S. KingeryH-Index: 47
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ABSTRACT It has been proposed that complex regional pain syndrome (CRPS) is a posttraumatic autoimmune disease. Previously, we observed that B cells contribute to CRPS-like changes in a mouse tibia fracture model, and that early ( 12 months duration) CRPS patient IgM (but not IgG) caused nociceptive sensitization in muMT fracture mice, but intraplantar injection of chronic CRPS IgM or IgG had no effect. We postulate that CRPS IgM antibodies bind to neoantigens in the fracture limb skin and corre...
#1Bernhard Baier (University of Mainz)H-Index: 23
#2Hannah CuvenhausH-Index: 1
Last. Marianne Dieterich (LMU: Ludwig Maximilian University of Munich)H-Index: 86
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BACKGROUND AND PURPOSE The aim of the study was to identify the neuroanatomical correlates and associations of neuropsychological syndromes after acute unilateral right-hemisphere brain lesions. The neuropsychological syndromes considered were orientation in three-dimensional space such as tilts of the subjective visual vertical or of the subjective haptic vertical, pusher syndrome, visual neglect and unawareness of paresis (anosognosia for hemiparesis). These neuropsychological phenomena have b...
ABSTRACT Matrix metalloproteinases (MMP)-2 and MMP-9 play important roles in inflammation as well as in pain processes. For this reason, we compared the concentrations of these enzymes in skin and serum of patients with complex regional pain syndrome (CRPS), other pain diseases and healthy subjects. We analyzed ipsi- and contralateral skin biopsies of 18 CRPS patients, as well as in 10 pain controls and 9 healthy subjects. Serum samples were analyzed from 20 CRPS, 17 pain controls and 17 healthy...
#1Andreas GoebelH-Index: 23
#2Frank BirkleinH-Index: 67
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#1Heidrun H. Krämer (University of Giessen)H-Index: 19
#2Cora Rebhorn (University of Mainz)H-Index: 5
Last. Frank Birklein (University of Mainz)H-Index: 67
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OBJECTIVE To explore small fiber somatosensory and sympathetic function in PD and MSA. METHODS We recruited 20 PD patients (7 women, median age 65.5 years; IQR 54.75-70.0), 10 MSA patients (4 women; median age 68 years; IQR 66.25-74.0), and 10 healthy subjects (HC; 4 women, median age 68; IQR 59.0-71.0 years). Autonomic testing included forehead cooling, intradermal microdialysis of norepinephrine (NE; 10-5; 10-6; 10-7; and 10-8), and orthostatic hypotension (OH); somatosensory testing included ...
#1Anthony Tucker-Bartley (Boston Children's Hospital)H-Index: 1
#2Jordan Lemme (Boston Children's Hospital)H-Index: 3
Last. Jaymin Upadhyay (Harvard University)H-Index: 21
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Abstract For patients diagnosed with a rare musculoskeletal or neuromuscular disease, pain may transition from acute to chronic; the latter yielding additional challenges for both patients and care providers. We assessed the present understanding of pain across a set of ten rare, noninfectious, noncancerous disorders; Osteogenesis Imperfecta, Ehlers-Danlos Syndrome, Achondroplasia, Fibrodysplasia Ossificans Progressiva, Fibrous Dysplasia/McCune-Albright Syndrome, Complex Regional Pain Syndrome, ...