Etto C. Eringa
Maastricht University
VasodilationInternal medicineMicrocirculationEndocrinologyPerfusionCardiologyAdipose tissueChemistryAdipokineInflammationEndotheliumType 2 diabetesInsulin resistanceInsulinSkeletal muscleVasoconstrictionObesityDiabetes mellitusMedicineBlood pressureBiology
106Publications
29H-index
2,922Citations
Publications 106
Newest
#1Edina Cenko (UNIBO: University of Bologna)H-Index: 17
#2Lina BadimonH-Index: 99
Last. Etto C. Eringa (UM: Maastricht University)H-Index: 29
view all 23 authors...
The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory and immune responses are characteristic features of severe COVID-19. Pre-existing cardiovascular disease and viral load are linked to myocardial injury and worse outcomes. The vascular response to cytokine production and the interaction between SARS-CoV-2 and...
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#1Joana Amado-Azevedo (UvA: University of Amsterdam)H-Index: 1
Last. Victor W.M. van Hinsbergh (UvA: University of Amsterdam)H-Index: 7
view all 13 authors...
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#1Camiel V J Box (UvA: University of Amsterdam)
#2Amandeep K Sandhu (UvA: University of Amsterdam)
Last. Etto C. Eringa (UM: Maastricht University)H-Index: 29
view all 7 authors...
Background null Vascular endothelial dysfunction is an essential part of the pathophysiology of type 2 diabetes and its complications. In type 2 diabetes, endothelial dysfunction is characterized by reduced insulin signaling and increased transendothelial transport of fatty acids (FA). As the Abl kinase inhibitor imatinib was previously shown to reverse type 2 diabetes and to inhibit VEGF signaling via Abl kinases, we studied the effect of imatinib on vascular insulin sensitivity and fatty acid ...
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#1Rio P. Juni (UvA: University of Amsterdam)H-Index: 3
#2Rushd Al-Shama (UvA: University of Amsterdam)H-Index: 1
Last. Victor W.M. van Hinsbergh (UvA: University of Amsterdam)H-Index: 7
view all 9 authors...
Abstract Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk leading to impairment of cardiomyocyte function is not known. The sodium-glucose co-transporter 2 inhibitor, empagliflozin, reduced cardiovascular events in diabetic patie...
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#1Jorn P. Meekel (UvA: University of Amsterdam)H-Index: 1
#2Marina Dias-Neto (University of Porto)H-Index: 6
Last. Kak K. Yeung (UvA: University of Amsterdam)H-Index: 13
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Objective Perivascular adipose tissue (PVAT) contributes to vascular homeostasis and is increasingly linked to vascular pathology. PVAT density and volume were associated with abdominal aortic aneurysm (AAA) presence and dimensions on imaging. However, mechanisms underlying the role of PVAT in AAA have not been clarified. This study aimed to explore differences in PVAT from AAA using gene expression and functional tests. Methods Human aortic PVAT and control subcutaneous adipose tissue were coll...
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#1Joana Amado-Azevedo (UvA: University of Amsterdam)H-Index: 1
Last. Coert Margadant (UvA: University of Amsterdam)H-Index: 5
view all 13 authors...
Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis and acute respiratory distress syndrome. We identified the kinase Arg/Abl2 as a mediator of endothelial barrier disruption, but the role of Arg in endothelial monolayer regulation and its relevance in vivo remain poorly understood. Here we show that depletion of Arg in endothelial cells results in the activation of both RhoA and Rac1, increased cel...
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#1Rio P. JuniH-Index: 3
#2Rushd Al-ShamaH-Index: 1
Last. Victor W.M. van HinsberghH-Index: 94
view all 9 authors...
Background: It has been proposed that diabetes and chronic kidney disease cause heart failure with preserved ejection fraction (HFpEF) through low-grade inflammation and microvascular endothelial dysfunction. We have previously shown that endothelial enhancement of cardiomyocyte contraction and relaxation is mediated by NO, impaired by cytokines, and restored upon treatment with the SGLT2 inhibitor Empagliflozin. Chronic kidney disease (CKD) is linked to diabetes and HFpEF and causes systemic en...
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#1Alexander H. Turaihi (UvA: University of Amsterdam)H-Index: 2
#2E.H. Serné (UvA: University of Amsterdam)H-Index: 8
Last. Etto C. Eringa (UvA: University of Amsterdam)H-Index: 29
view all 13 authors...
Insulin-mediated microvascular recruitment (IMVR) regulates delivery of insulin and glucose to insulin-sensitive tissues. We have previously proposed that perivascular adipose tissue (PVAT) controls vascular function through outside-to-inside communication and through vessel-to-vessel, or “vasocrine” signaling. However, direct experimental evidence supporting a role of local PVAT in regulating IMVR and insulin sensitivity in vivo is lacking. Here, we studied muscles with and without PVAT in mice...
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#1Michelle A. Keske (UTAS: University of Tasmania)H-Index: 16
#2Eugene J. Barrett (UVA: University of Virginia)H-Index: 67
Last. Etto C. Eringa (UvA: University of Amsterdam)H-Index: 29
view all 12 authors...
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#1Emily Attrill (UTAS: University of Tasmania)H-Index: 3
#2Ciaran J Ramsay (UTAS: University of Tasmania)H-Index: 2
Last. Dino Premilovac (UTAS: University of Tasmania)H-Index: 9
view all 8 authors...
The matching of capillary blood flow to metabolic rate of the cells within organs and tissues is a critical microvascular function which ensures appropriate delivery of hormones and nutrients, and the removal of waste products. This relationship is particularly important in tissues where local metabolism, and hence capillary blood flow, must be regulated to avoid a mismatch between nutrient demand and supply that would compromise normal function. The consequences of a mismatch in microvascular b...
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