Nagarajan Selvamurugan
SRM University
GeneInternal medicineBiomedical engineeringmicroRNAMolecular biologyChemistryMaterials scienceMesenchymal stem cellRUNX2OsteoblastChitosanParathyroid hormoneBone regenerationBone tissue engineeringChemical engineeringTissue engineeringCancer researchTranscription factorBiologyProtein adsorptionCell biology
160Publications
59H-index
9,002Citations
Publications 152
Newest
#1A. Moorthi (SRM University)H-Index: 17
#2Selvaraj Vimalraj (SRM University)H-Index: 17
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Abstract Osteoblast differentiation is tightly regulated by post transcriptional regulators such as microRNAs (miRNAs). Several bioactive materials including nano-bioglass ceramic particles (nBGC) influence differentiation of the osteoblasts, but the molecular mechanisms of nBGC-stimulation of osteoblast differentiation via miRNAs are not yet determined. In this study, we identified that nBGC-treatment stimulated miR-30c expression in human osteoblastic cells (MG63). The bioinformatics tools ide...
44 CitationsSource
#1Ramesh Niranjan (SRM University)H-Index: 1
#2Chandru Koushik (SRM University)H-Index: 1
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/β-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (β-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room temperature and turned into a gel at body temperature. The hydrogel was characterized by SEM, EDX, XRD, FT-IR and swelling stud...
99 CitationsSource
: The central dogma of transfer of genetic information from DNA to protein via mRNA is now challenged by small fragment of non coding RNAs typically 19-25 nucleotides in length namely microRNAs (miRNAs). miRNAs regulate expression of the protein coding genes by interfering in their mRNAs and, thus, act as key regulators of diverge cellular activities. Osteoblast differentiation, a key step in skeletal development involves activation of several signalling pathways including TGFb, BMP, Wnt and tra...
76 Citations
BACKGROUND: Breast cancer is the most common cancer affecting women in the world today. Matrix metalloproteinases (MMPs) are a family of endopeptidases that can degrade extracellular matrix proteins and promote cell invasion and metastasis. MMPs are differentially expressed and their expressions are often associated with a poor prognosis for patients. OBJECTIVE: The aim of this study is to investigate and compare the expression of MMPs in different grades of human breast cancer tissues with norm...
31 CitationsSource
#1A. Moorthi (SRM University)H-Index: 17
#2Sekaran Saravanan (SRM University)H-Index: 31
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
view all 7 authors...
19 CitationsSource
#1Anjali Tripathi (SRM University)H-Index: 3
#2Sekaran Saravanan (SRM University)H-Index: 31
Last. Nagarajan Selvamurugan (NYU: New York University)H-Index: 59
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Abstract The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu–Zn alloy nanoparticles (nCu–Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu–Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu–Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial ac...
107 CitationsSource
#1Maddela Swetha (SRM University)H-Index: 4
#2Kolli SahithiH-Index: 4
Last. Nagarajan SelvamuruganH-Index: 59
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: The bone implants used in tissue repair are susceptible to infections caused by staphylococci, specifically Staphylococcus aureus. Hence, the development of better biological materials that provide antimicrobial activity in bone tissue engineering is required. The nanoparticles of hydroxyapatite (nHAp) and nHAp dopped with Zn (nHAp-Zn) were prepared by the wet chemical method and the ion exchange method, respectively. They were characterized using SEM, AFM, FTIR and XRD. The antibacterial acti...
33 CitationsSource
#1Soumitri Pattnaik (SRM University)H-Index: 3
#2Sricharan Nethala (SRM University)H-Index: 2
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Abstract A scaffold harboring the desired features such as biodegradation, biocompatibility, porous structure could serve as template for bone tissue engineering. In the present study, chitosan (CS), nano-scaled silicon dioxide (Si) and zirconia (Zr) were combined by freeze drying technique to fabricate a bio-composite scaffold. The bio-composite scaffold (CS/Si/Zr) was characterized by SEM, XRD and FT-IR studies. The scaffold possessed a porous nature with pore dimensions suitable for cell infi...
70 CitationsSource
#1Sekaran Saravanan (SRM University)H-Index: 31
#2Sricharan Nethala (SRM University)H-Index: 2
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Abstract In this study, a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver particles (CS/nHAp/nAg) was developed by freeze drying technique, followed by introduction of silver ions in controlled amount through reduction phenomenon by functional groups of chitosan. The scaffolds were characterized using SEM, FT-IR, XRD, swelling, and biodegradation studies. The testing of the prepared scaffolds with Gram-positive and Gram-negative bacterial strains showed antibacterial a...
188 CitationsSource
#1Sridhar Muthusami (University of Madras)H-Index: 9
#2Krishnamoorthy Senthilkumar (University of Madras)H-Index: 1
Last. Narasimhan Srinivasan (SRM University)H-Index: 26
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Osteoporosis is a public health problem which is associated with significant morbidity and mortality. The repair of bone defect is still a big challenge for orthopedic surgeons. Traditional use of Cissus quadrangularis (C. quadrangularis) in the treatment of bone disorders has been documented. The present study was employed to delineate the effects of ethanolic extract of C. quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells. Lact...
41 CitationsSource