Andrew M. Atz
Medical University of South Carolina
Internal medicineSurgeryCardiologyRetrospective cohort studyRandomized controlled trialHemodynamicsPediatricsProspective cohort studyNorwood procedureFontan procedureCardiac surgeryCardiopulmonary bypassVentricleHypoplastic left heart syndromeHeart diseasePopulationPerioperativeAnesthesiaClinical trialMedicineCohort
Publications 210
#1Robert D. AnnettH-Index: 20
#2Scott BickelH-Index: 4
Last. Kurtis R. KulbethH-Index: 1
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#1Sinai C. Zyblewski (MUSC: Medical University of South Carolina)H-Index: 14
#2Renee H. Martin (MUSC: Medical University of South Carolina)H-Index: 26
Last. Eric M. Graham (MUSC: Medical University of South Carolina)H-Index: 20
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Abstract Background Neurodevelopmental impairment is a significant consequence for survivors of surgery for critical congenital heart disease. This study sought to determine if intraoperative methylprednisolone during neonatal cardiac surgery is associated with neurodevelopmental outcomes at 12 months of age and to identify early prognostic variables associated with neurodevelopmental outcomes. Methods A planned secondary analysis of a two-center, double-blind, randomized, placebo-controlled tri...
#1Ryan J. Butts (UTSW: University of Texas Southwestern Medical Center)H-Index: 13
#2Andrew M. Atz (MUSC: Medical University of South Carolina)H-Index: 55
Last. Lynn Mahony (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
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Increased circulating catecholamines are associated with worse exercise performance in adult heart failure patients. Patients with Fontan physiology have increased circulating catecholamines and theoretically could benefit from beta blockade. We hypothesized that carvedilol would improve exercise performance in Fontan patients. A double-blind, placebo-controlled, crossover trial of carvedilol was performed. Single ventricle patients between the ages of 10 and 35 years with a previous Fontan oper...
#1Allison Ross Eckard (MUSC: Medical University of South Carolina)H-Index: 15
#2Kenneth M. Borow (Bryn Mawr College)H-Index: 5
Last. Andrew M. Atz (MUSC: Medical University of South Carolina)H-Index: 55
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Multisystem inflammatory syndrome in children (MIS-C) is a serious postinfectious immune dysregulation associated with coronavirus disease 2019 that may present with severe and life-threatening cardiovascular dysfunction, hemodynamic instability, shock, and multisystem organ failure. Optimal treatment is unknown. Current standard of care consists of nonspecific anti-inflammatory and antithrombotic therapies. Interventions that target MIS-C’s distinctive clinical features and immunophenotype are ...
1 CitationsSource
#1Renee Sananes (U of T: University of Toronto)H-Index: 13
#2Caren S. Goldberg (UM: University of Michigan)H-Index: 41
Last. Cheryl L. Brosig (MCW: Medical College of Wisconsin)H-Index: 17
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OBJECTIVES To determine if neurodevelopmental deficits in children with single-ventricle physiology change with age and early developmental scores predict 6-year outcomes. METHODS In the Single Ventricle Reconstruction Trial, Bayley Scales of Infant Development, Second Edition, were administered at 14 months of age, and parents completed the Behavior Assessment System for Children, Second Edition (BASC-2) annually from the ages of 2 to 6 years. Scores were classified as average, at risk, or impa...
2 CitationsSource
#1David J. Goldberg (Children's Hospital of Philadelphia)H-Index: 28
#2Victor ZakH-Index: 17
Last. Stephen M. Paridon (Children's Hospital of Philadelphia)H-Index: 42
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Impaired exercise following Fontan is a surrogate of morbidity. Single-center longitudinal data exist, but there is a lack of contemporary multi-center data. Ramp cycle ergometry was re-performed in consented participants who had originally participated in the Pediatric Heart Network’s Fontan cross-sectional study. Annualized change was evaluated at maximal and submaximal exercise. Associations between these outcomes and patient characteristics were analyzed. There were 336 participants in Fonta...
4 CitationsSource
#1Leslie Young (UVM: University of Vermont)H-Index: 3
#2Zhuopei HuH-Index: 2
Last. Lori A. Devlin (University of Louisville)H-Index: 6
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BACKGROUND AND OBJECTIVES: Variation in pediatric medical care is common and contributes to differences in patient outcomes. Site-to-site variation in the characteristics and care of infants with neonatal opioid withdrawal syndrome (NOWS) has yet to be quantified. Our objective was to describe site-to-site variation in maternal-infant characteristics, infant management, and outcomes for infants with NOWS. METHODS: Cross-sectional study of 1377 infants born between July 1, 2016, and June 30, 2017...
4 CitationsSource
#1Stephanie S. Gaydos (MUSC: Medical University of South Carolina)H-Index: 2
#2Shahryar M. Chowdhury (MUSC: Medical University of South Carolina)H-Index: 10
Last. Kimberly E McHugh (Sewanee: The University of the South)
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Introduction: Patients with Fontan circulation often develop multiorgan dysfunction. Obesity is a risk factor for systemic complications in the general population, but the impact of obesity in Font...
#2Carolyn L. Taylor (MUSC: Medical University of South Carolina)H-Index: 7
Last. Andrew M. AtzH-Index: 55
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Introduction: The objective of this study was to investigate the association of contractility, afterload, and diastolic dysfunction to exercise function between patients with heart failure and pres...
#1Shufan Ge (UNC: University of North Carolina at Chapel Hill)H-Index: 2
#2Susan R. Mendley (UMB: University of Maryland, Baltimore)H-Index: 19
Last. Daniel Gonzalez (UNC: University of North Carolina at Chapel Hill)H-Index: 16
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Metoclopramide is commonly used for gastroesphageal reflux. The aims of the present study were to develop a pediatric population pharmacokinetic (PopPK) model, which was applied to simulate the metoclopramide exposure following dosing used in clinical practice. Opportunistic pharmacokinetic (PK) data were collected from pediatric patients receiving enteral or parenteral metoclopramide per standard of care and these data were simultaneously fitted using NONMEM(R). Allometric scaling with body wei...