Rachele Riganò
Istituto Superiore di Sanità
Peripheral blood mononuclear cellImmunoglobulin EPathologyAntigenAntibodyAutoantibodyProinflammatory cytokineChemistryImmunologyT cellOxidative stressInflammationEchinococcus granulosusCytokineAutoimmunityEndothelial dysfunctionMedicineBiologyImmune systemCell biology
103Publications
31H-index
2,644Citations
Publications 102
Newest
Macrophage activation and polarization play a central role in atherosclerotic plaque fate. The M1/M2 activation phenotypes represent two profiles of the macrophage polarization state. During atherosclerosis regression or stabilization, macrophages switch from M1 proinflammatory phenotype to M2 anti-inflammatory reparative one. Here, we investigated whether the natural compound lupeol, a pentacyclic triterpene, induces phenotypical and functional changes in human M1 macrophages and counteracts th...
2 CitationsSource
#1Brigitta Buttari (ISS: Istituto Superiore di Sanità)H-Index: 25
#2Elisabetta Profumo (ISS: Istituto Superiore di Sanità)H-Index: 28
Last. Rachele Riganò (ISS: Istituto Superiore di Sanità)H-Index: 31
view all 8 authors...
β-Thalassemia is an inherited single gene disorder related to reduced synthesis of the β-globin chain of hemoglobin. Patients with β-thalassemia present variable clinical severity ranging from asymptomatic trait to severe transfusion-dependent anemia and multiple organs complications. Moreover, multiple immune abnormalities are a major concern in β-thalassemia patients. Aberrant neutrophil effector function plays a pivotal role in infection susceptibility in these patients. In severe and persist...
Source
#1Brigitta Buttari (ISS: Istituto Superiore di Sanità)H-Index: 25
#2Elisabetta Profumo (ISS: Istituto Superiore di Sanità)H-Index: 28
Last. Rachele Riganò (ISS: Istituto Superiore di Sanità)H-Index: 31
view all 6 authors...
AbstractAntiphospholipid antibody syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombosis and/or pregnancy morbidity. The incidence is around five new cases/...
2 CitationsSource
#1Elisabetta Profumo (ISS: Istituto Superiore di Sanità)H-Index: 28
#2Brigitta Buttari (ISS: Istituto Superiore di Sanità)H-Index: 25
Last. Rachele Riganò (ISS: Istituto Superiore di Sanità)H-Index: 31
view all 14 authors...
We have previously demonstrated that human heat shock protein 90 (HSP90), an intracellular self protein, is the target of cellular and humoral autoimmune responses in patients with carotid atherosclerosis. In this study, we evaluated in vitro whether oxidative stress, a feature of atherosclerotic plaque, alters HSP90 expression in endothelial cells, thus inducing surface localization of this molecule and whether the antioxidant compound 7,8-dihydroxy-4-methylcoumarin (7,8-DHMC) is able to preven...
7 CitationsSource
#1Rita BusinaroH-Index: 18
#2Ilia J. ElenkovH-Index: 31
Last. Rachele RiganòH-Index: 31
view all 10 authors...
Source
#1Elisabetta Profumo (ISS: Istituto Superiore di Sanità)H-Index: 28
#2Brigitta Buttari (ISS: Istituto Superiore di Sanità)H-Index: 25
Last. Rachele Riganò (ISS: Istituto Superiore di Sanità)H-Index: 31
view all 8 authors...
Atherosclerosis is characterized by endothelial dysfunction, mainly induced by inflammation and oxidative stress. Increased reactive oxygen species (ROS) production together with increased adhesion molecules and thrombogenic tissue factor (TF) expression on endothelial cells has a key role in proatherogenic mechanisms. Therefore downmodulation of these molecules could be useful for reducing the severity of inflammation and atherosclerosis progression. Dehydrozingerone (DHZ) is a nutraceutical co...
10 CitationsSource
#1Maurizio Sorice (Sapienza University of Rome)H-Index: 45
#2Brigitta Buttari (ISS: Istituto Superiore di Sanità)H-Index: 25
Last. Rachele Riganò (ISS: Istituto Superiore di Sanità)H-Index: 31
view all 12 authors...
Anti-phospholipid antibody syndrome (APS) is a systemic autoimmune disease characterized clinically by arterial and/or venous thromboses, recurrent abortions or fetal loss and serologically by the presence of 'anti-phospholipid antibodies' (aPL). The main target antigen of the antibodies is β2 glycoprotein I (β2 GPI). Post-translational oxidative modifications of the protein have been widely described. In this study we aimed to analyse sera reactivity to glucose-modified β2 GPI (G-β2 GPI). Sera ...
5 CitationsSource
Macrophages are key cellular mediators of innate immunity: they are positionally and transcriptionally programmed to respond to pathogens and environmental challenges. When activated by inflammatory signals in their microenvironment they develop into functionally and phenotypically distinct polarized subpopulations: classically activated macrophages, M1, characterized by cytotoxix/proinflammatory activity; alternatively activated macrophages, M2, characterized by anti-inflammatory/wound repair a...
Source
#1Brigitta Buttari (ISS: Istituto Superiore di Sanità)H-Index: 25
#2Elisabetta Profumo (ISS: Istituto Superiore di Sanità)H-Index: 28
Last. Rachele Riganò (ISS: Istituto Superiore di Sanità)H-Index: 31
view all 3 authors...
Atherosclerosis is a chronic multifactorial disease of the arterial wall characterized by inflammation, oxidative stress, and immune system activation. Evidence exists on a pathogenic role of oxidized red blood cells (RBCs) accumulated in the lesion after intraplaque hemorrhage. This review reports current knowledge on the impact of oxidative stress in RBC modifications with the surface appearance of senescent signals characterized by reduced expression of CD47 and glycophorin A and higher exter...
50 CitationsSource
Cardiovascular diseases, which are the leading cause of mortality in the Western World, are closely associated with atherosclerosis development. Atherosclerosis is a chronic multifactorial disease of the arterial wall characterized by endothelial dysfunction, inflammation and oxidative stress. Oxidative stress is an alteration of the balance between pro-oxidant and antioxidant mechanisms which promotes vascular complications and represents a valid therapeutic target to prevent or treat cardiovas...
35 CitationsSource