Olivera Casar-Borota
Uppsala University
EndocrinologyPathologyImmunohistochemistrySomatostatinATRXAdenomaAcromegalyPituitary glandNeuroendocrine tumorsPituitary adenomaContext (language use)OctreotidePituitary tumorsPituitary neoplasmSomatostatin receptor-5Cancer researchMedicineCorticotropic cellSomatostatin receptorBiology
Publications 54
#1Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 86
#2Ozgur Mete (UHN: University Health Network)H-Index: 32
Last. Shereen Ezzat (UHN: University Health Network)H-Index: 57
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The classification of adenohypophysial neoplasms as "pituitary neuroendocrine tumors" (PitNETs) was proposed in 2017 to reflect their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors ranging from small indolent lesions to large, locally invasive, unresectable tumors. Tumor growth and hormone hypersecretion cause significant morbidity and mortality in a subset of patients. The proposal was endorsed by a WHO working group that sought to provide a unified...
#1Jimmy SundblomH-Index: 1
#2Fabjola Xheka (Uppsala University)
Last. Mats RyttleforsH-Index: 11
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#1Olivera Casar-Borota (Uppsala University)H-Index: 14
#2Henning B. Boldt (OUH: Odense University Hospital)H-Index: 6
Last. Pia Burman (Lund University)H-Index: 25
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Context Aggressive pituitary tumours (APTs) are characterised by unusually rapid growth and lack of response to standard treatment. About 1-2% develop metastases being classified as pituitary carcinomas (PCs). For unknown reasons, the corticotroph tumours are overrepresented amongst APTs and PCs. Mutations in the ATRX gene, regulating chromatin remodelling and telomere maintenance, have been implicated in the development of several cancer types, including neuroendocrine tumours. Objective To stu...
3 CitationsSource
#1Lilian Vasaitis (Uppsala University)H-Index: 6
#2Johan Wikström (Uppsala University)H-Index: 22
Last. Olivera Casar-Borota (Uppsala University)H-Index: 14
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IgG4-related hypophysitis (IgG4-RH) is increasingly being reported as an isolated entity or, less frequently, as a manifestation of a multiorgan IgG4-related disease (IgG4-RD), in which typical histopathology is a cornerstone for the diagnosis. We aimed to describe the histopathological changes in the surgical specimens from patients with clinical signs of pituitary disease that fulfilled the current diagnostic criteria for IgG4-RH. Histopathological features were correlated with clinical and ra...
#1Axel Tjörnstrand (University of Gothenburg)H-Index: 3
#2Olivera Casar-Borota (Uppsala University)H-Index: 14
Last. Helena Filipsson Nyström (University of Gothenburg)H-Index: 14
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OBJECTIVES Somatostatin receptors (SSTRs) are potential targets for detecting pituitary neuroendocrine tumors (PitNETs) that can be visualized effectively with 68 Ga-labeled PET tracers. With this study, we have evaluated the diagnostic properties of such a tracer, 68 Ga-DOTATOC, in patients with hormone-producing PitNETs before and after surgery. DESIGN /Methods This prospective case-control study presents preoperative positron emission tomography (PET) and histopathological data in 18 patients...
1 CitationsSource
#1Evelina SjöstedtH-Index: 15
Last. Olivera Casar-BorotaH-Index: 14
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Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for TGFBR3L staining and combined with SF1 and FSH for a 3-plex fluorescent protocol, providing more details about the cell lineage specificity of TGFBR3L expression. A cohort ...
#1Marco Savarese (UH: University of Helsinki)H-Index: 14
#2Anna Vihola (UH: University of Helsinki)H-Index: 22
Last. Bjarne Udd (UH: University of Helsinki)H-Index: 54
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High throughput sequencing analysis has facilitated the rapid analysis of the entire titin (TTN) coding sequence. This has resulted in the identification of a growing number of recessive titinopathy patients. The aim of this study was to (1) characterize the causative genetic variants and clinical features of the largest cohort of recessive titinopathy patients reported to date and (2) to evaluate genotype–phenotype correlations in this cohort. We analyzed clinical and genetic data in a cohort o...
2 CitationsSource
#1Anders Jensen Kolnes (University of Oslo)H-Index: 2
#2Kristin Astrid Berland Øystese (University of Oslo)H-Index: 5
Last. Anders Palmstrøm Jørgensen (Oslo University Hospital)H-Index: 10
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CONTEXT: Gonadotroph pituitary neuroendocrine tumors (PitNETs) can express FSH and LH or be hormone negative, but they rarely secrete hormones. During tumor development, epithelial cells develop a mesenchymal phenotype. This process is characterized by decreased membranous E-cadherin and translocation of E-cadherin to the nucleus. Estrogen receptors (ER) regulate both E-cadherin and FSH expression and secretion. Whether the hormone status of patients with gonadotroph PitNETs is regulated by EMT ...
3 CitationsSource