Francesca Degrassi
Sapienza University of Rome
Binucleated cellsDNA damageTopoisomeraseMolecular biologyKinetochoreChinese hamsterSister chromatid exchangeAneuploidyCell cycleChromosomeMicronucleusMicronucleus testAnaphaseGeneticsDNACell growthSister chromatidsBiologyMitosisCell biology
83Publications
30H-index
3,253Citations
Publications 75
Newest
#1Francesca Degrassi (Sapienza University of Rome)H-Index: 30
#2Michela Damizia (Sapienza University of Rome)H-Index: 2
Last. Patrizia Lavia (Sapienza University of Rome)H-Index: 36
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Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how microcephaly-related mitotic genes operate in the control of chromosome segregation during mitosis...
6 CitationsSource
#2David Sasah Staid (Sapienza University of Rome)H-Index: 2
Last. Renata CozziH-Index: 21
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Resveratrol and its natural stilbene-containing derivatives have been extensively investigated as potential chemotherapeutic agents. The synthetic manipulation of the stilbene scaffold has led to the generation of new analogues with improved anticancer activity and better bioavailability. In the present study we investigated the anticancer activity of a novel trimethoxystilbene derivative (3,4,4′-trimethoxylstilbene), where two methoxyl groups are adjacent on the benzene ring (ortho configuratio...
3 CitationsSource
#1Antonella Russo (UNIPD: University of Padua)H-Index: 20
#2Francesca Degrassi (National Research Council)H-Index: 30
Abstract The purpose of this review is to provide an historical overview of the molecular cytogenetic approaches that have been pursed to identify the mechanism of origin of micronuclei as well as highlight the significance of the findings obtained for the understanding of the molecular action of harmful agents in the micronucleus assay. Then, we summarize recent exciting findings that have been obtained by applying molecular approaches to analyze the biology of micronuclei. These findings empha...
17 CitationsSource
#2Mario FioreH-Index: 17
Last. Renata CozziH-Index: 21
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Natural compounds are extensively studied for their potential use in traditional and non-traditional medicine. Several natural and synthetic Resveratrol analogues have shown interesting biological activities in the field of cancer chemoprevention. In the present study, we have focused on the ability of Resveratrol and two methoxylated derivatives (Trimethoxystilbene and Pterostilbene) to inhibit human cancer cell growth particularly analyzing their ability to interfere with tubulin dynamics at m...
7 CitationsSource
#1Ángel Sánchez-Lamar (UH: University of Havana)H-Index: 9
Last. Francesca DegrassiH-Index: 30
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Abstract Ethnopharmacological relevance Xanthium strumarium L. is a member of the Asteraceae family popularly used with multiple therapeutic purposes. Whole extracts of this plant have shown anti-mitotic activity in vitro suggesting that some components could induce mitotic arrest in proliferating cells. Aim of the sudy Aim of the present work was to characterize the anti-mitotic properties of the X. strumarium whole extract and to isolate and purify active molecule(s). Materials and methods The...
5 CitationsSource
Abstract Resveratrol (3,4′,5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histo...
8 CitationsSource
#2Mario FioreH-Index: 17
Last. Renata CozziH-Index: 21
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Various naturally occurring stilbene-like compounds that are related to resveratrol (RSV) possess some of the beneficial effects of the parent molecule and provide even further benefits. Therefore, a series of methoxylated analogues of RSV were prepared with the aim of increasing antitumour and proapoptotic activity. In a previous article, we studied two methoxy-derivatives, pterostilbene (PTERO) and trimethoxystilbene (TRIMETHOXY), in which the first was formed by the substitution of two hydrox...
11 CitationsSource
#1Maria Di Bari (Sapienza University of Rome)H-Index: 10
#2Vanessa Tombolillo (Sapienza University of Rome)H-Index: 1
Last. Ada Maria Tata (Sapienza University of Rome)H-Index: 21
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Abstract Glioblastomas are the most common brain tumors in humans. Previously, we demonstrated that the muscarinic receptor agonist, arecaidine propargyl ester, via M2 receptors, inhibits cell proliferation in a time and dose-dependent manner and induces a severe apoptosis in human U251 and U87 glioblastoma cell lines. In order to clarify the mechanisms causing apoptosis after arecaidine treatment, we analyzed the ability of arecaidine to induce oxidative stress. By dichloro-dihydro-fluorescein ...
14 CitationsSource
#1Antonella Russo (UNIPD: University of Padua)H-Index: 20
Last. Francesca DegrassiH-Index: 30
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Genomic instability leads to a wide spectrum of genetic changes, including single nucleotide mutations, structural chromosome alterations, and numerical chromosome changes. The accepted view on how these events are generated predicts that separate cellular mechanisms and genetic events explain the occurrence of these types of genetic variation. Recently, new findings have shed light on the complexity of the mechanisms leading to structural and numerical chromosome aberrations, their intertwining...
21 CitationsSource
#1Dimitris StellasH-Index: 14
Last. Soterios A. KyrtopoulosH-Index: 34
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a b s t r a c t The environmental carcinogen benzo(a)pyrene (B(a)P) after being metabolised by cytochrome P450 enzymes forms DNA adducts. This abnormal situation induces changes in the cell cycle, DNA damage, chromosomal and mitotic aberrations, all of which may be related to carcinogenesis. In order to further investigate the mechanistic basis of these effects, HepG2 cells were treated with 3 M B(a)P for various time periods, followed by further incubation in the absence of B(a)P for up to 192 ...
7 CitationsSource
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