Fredrik J. Swartling
Uppsala University
GeneCancerNeural stem cellPathologyCellImmunologySonic hedgehogGliomaSOX9MetastasisBrain tumorMedulloblastomaStem cellCancer researchSignal transductionComputational biologyMedicineBromodomainTranscription factorBiology
88Publications
17H-index
1,343Citations
Publications 87
Newest
#1Linxuan Zhao (Uppsala University)
#2Pengwei Xing (Uppsala University)
Last. Irem Yildirim (Science for Life Laboratory)
view all 14 authors...
The majority of biopsies in both basic research and translational cancer studies are preserved in the format of archived formalin-fixed paraffin-embedded (FFPE) samples. Profiling histone modifications in archived FFPE tissues is critically important to understand gene regulation in human disease. The required input for current genome-wide histone modification profiling studies from FFPE samples is either 10-20 tissue sections or whole tissue blocks, which prevents better resolved analyses. But ...
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#1Christelle Adolphe (UQ: University of Queensland)H-Index: 11
#2Amanda Millar (UQ: University of Queensland)H-Index: 3
Last. Laura A. Genovesi (UQ: University of Queensland)H-Index: 6
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Medulloblastoma (MB) is the most common malignant pediatric brain tumour and there is an urgent need for molecularly targeted and subgroup-specific therapies. The stem cell factor SOX9, has been proposed as a potential therapeutic target for the treatment of Sonic Hedgehog medulloblastoma (SHH-MB) subgroup tumors, given its role as a downstream target of Hedgehog signaling and in functionally promoting SHH-MB metastasis and treatment resistance. However, the functional requirement for SOX9 in th...
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#1Vamsi Krishna Polavarapu (Uppsala University)
#2Pengwei Xing (Uppsala University)
Last. Xingqi Chen (Uppsala University)H-Index: 10
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Archived formalin-fixed paraffin-embedded (FFPE) samples are the global standard format for preservation of the majority of biopsies in both basic research and translational cancer studies, and profiling chromatin accessibility in the archived FFPE tissues is fundamental to understanding gene regulation. Accurate mapping of chromatin accessibility from FFPE specimens is challenging because of the high degree of DNA damage. Here, we first showed that standard ATAC-seq can be applied to purified F...
1 CitationsSource
#1Kilian ColasH-Index: 1
#2Karl O. HolmbergH-Index: 2
Last. Christine DyragerH-Index: 1
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#1Erin F. Simonds (UCSF: University of California, San Francisco)H-Index: 19
#2Edbert D. Lu (UCSF: University of California, San Francisco)H-Index: 1
Last. Mats Hellström (Uppsala University)H-Index: 31
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BACKGROUND Glioblastoma (GBM) is refractory to immune checkpoint inhibitor (ICI) therapy. We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain, and if it can be reversed. METHODS We used CyTOF mass cytometry to compare the tumor immune microenvironments (TIME) of human tumors that are generally ICI-refractory (GBM and sarcoma) or ICI-responsive (renal cell carcinoma), as well as mouse models...
2 CitationsSource
#4Miao Zhao (Science for Life Laboratory)
#5Gabriela Rosen (Science for Life Laboratory)H-Index: 1
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#1Tracy J. Berg (Lund University)H-Index: 1
#2Carolina MarquesH-Index: 3
Last. Alexander Pietras (Lund University)H-Index: 15
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The tumor microenvironment plays an essential role in supporting glioma stemness and radioresistance. Following radiotherapy, recurrent gliomas form in an irradiated microenvironment. Here we report that astrocytes, when pre-irradiated, increase stemness and survival of co-cultured glioma cells. Tumor-naive brains increased reactive astrocytes in response to radiation, and mice subjected to radiation prior to implantation of glioma cells developed more aggressive tumors. Extracellular matrix der...
4 CitationsSource
#1Anna Borgenvik (Science for Life Laboratory)H-Index: 1
#2Matko Čančer (KI: Karolinska Institutet)H-Index: 5
Last. Fredrik J. Swartling (Science for Life Laboratory)H-Index: 17
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Misregulation of MYC genes, causing MYC overexpression or protein stabilization, is observed in more than half of all cancers highlighting their important roles as oncogenes. Brain tumors in children have recently become the most lethal of all pediatric malignancies and the most common malignant primary adult brain tumor, glioblastoma, is still practically incurable. MYCN is one of three MYC family members and is crucial for normal brain development. It is associated with poor prognosis in many ...
1 CitationsSource
#1Sara Bolin (Uppsala University)H-Index: 10
#2Vasil Savov (Uppsala University)H-Index: 4
Last. Fredrik J. Swartling (Uppsala University)H-Index: 17
view all 29 authors...
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#1Erin F. Simonds (University of California, Berkeley)H-Index: 19
#2Edbert D. Lu (University of California, Berkeley)H-Index: 1
Last. Mats Hellström (Uppsala University)H-Index: 31
view all 21 authors...
BackgroundGlioblastoma (GBM) is refractory to checkpoint blockade immunotherapy (CPI). We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain, and if it can be reversed. MethodsWe used CyTOF mass cytometry to compare the tumor immune microenvironments (TIME) of human tumors that are generally CPI-refractory (GBM and sarcoma) or CPI-responsive (renal cell carcinoma), as well as mouse models of ...
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