Arduino A. Mangoni
Flinders Medical Centre
Internal medicineEndocrinologySurgeryCardiologyIntensive care medicineChemistryOxidative stressHomocysteineRheumatoid arthritisDiseaseAsymmetric dimethylarginineDrugPopulationAnesthesiaClinical trialMedicineBlood pressureGastroenterologyMeta-analysisPharmacology
Publications 381
#1Maria Carmina Pau (University of Sassari)H-Index: 3
#2Elisabetta ZinelluH-Index: 16
Last. Pietro Pirina (University of Sassari)H-Index: 26
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Oxidative stress induced by nocturnal intermittent hypoxia plays a significant pathophysiological role in obstructive sleep apnea (OSA). Malondialdehyde (MDA), one of the most commonly investigated markers of lipid peroxidation, might assist with the monitoring of oxidative balance in OSA. We conducted a systematic review and meta-analysis to evaluate the differences in circulating MDA concentrations between patients with OSA and non-OSA controls. A systematic search was conducted in the electro...
#1Rajiv Ananthakrishna (Flinders Medical Centre)H-Index: 2
#2Sau L Lee (Flinders Medical Centre)
Last. Joseph B. Selvanayagam (Flinders Medical Centre)H-Index: 47
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ABSTRACT null null Background null The presence and extent of left ventricular hypertrophy (LVH) is a major determinant of symptoms in patients with hypertrophic cardiomyopathy (HCM). There is increasing evidence to suggest that myocardial energetic impairment represents a central mechanism leading to LVH in HCM. There is currently a significant unmet need for disease-modifying therapy that regresses LVH in HCM patients. Perhexiline, a potent carnitine palmitoyl transferase-1 (CPT-1) inhibitor, ...
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Arduino A. Mangoni (Flinders University)H-Index: 40
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Alterations in cardiac biomarkers have been reported in patients with coronavirus disease 2019 (COVID-19) in relation to disease severity and mortality. We conducted a systematic review and meta-analysis with meta-regression of studies reporting B-type natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) plasma concentrations in COVID-19. We searched PubMed, Web of Science, and Scopus, between January 2020 and 2021, for studies reporting BNP/NT-proBNP concentrations, measures of COVID-19 s...
#1Richard J. Woodman (Flinders University)H-Index: 50
#2Kimberley BryantH-Index: 1
Last. Arduino A. Mangoni (Flinders University)H-Index: 40
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Background: The Multidimensional Prognostic Index (MPI) is an aggregate, comprehensive, geriatric assessment scoring system derived from eight domains that predict adverse outcomes, including 12-month mortality. However, the prediction accuracy of using the three MPI categories (mild, moderate, and severe risk) was relatively poor in a study of older hospitalized Australian patients. Prediction modeling using the component domains of the MPI together with additional clinical features and machine...
#1Gian L. ErreH-Index: 2
#1Gian Luca ErreH-Index: 17
Last. Mario PigaH-Index: 21
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#1Alena Kozlova (TUD: Dresden University of Technology)H-Index: 4
#2Vinitha Nair Ragavan (TUD: Dresden University of Technology)
Last. Raul R. Gainetdinov (SPbU: Saint Petersburg State University)H-Index: 90
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The endogenous methylated derivative of ʟ-arginine, Nω,Nω'-dimethyl-ʟ-arginine (asymmetric dimethylarginine, ADMA), an independent risk factor in many diseases, inhibits the activity of nitric oxide synthases and, consequently, modulates the availability of nitric oxide. While most studies on the biological role of ADMA have focused on endothelial and inducible nitric oxide synthases modulation and its contribution to cardiovascular, metabolic, and renal diseases, a role in regulating neuronal n...
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Yusra M. A. Ahmed (College of Health Sciences, Bahrain)
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. A common denominator of these complications is the myofibroblast-driven excessive deposition of extracellular matrix proteins. Although fibroblast appears to be the primary source of myofibroblasts, other cells, including endothelial cells, can generate myofibroblasts throu...
#1Ganessan Kichenadasse (Flinders Medical Centre)H-Index: 19
#2John O. MinersH-Index: 84
Last. Michael J. SorichH-Index: 29
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Background Concomitant use of proton pump inhibitors (PPIs) may negatively affect the efficacy of anticancer drugs such as fluoropyrimidines in patients with colorectal cancer (CRC). The primary objective of this study was to assess whether there is an association between concomitant PPI use and survival outcomes in patients with CRC treated with a fluoropyrimidine-based chemotherapy. Patients and methods A secondary analysis of 6 randomized controlled clinical trials in patients with advanced C...
#1Alessandro G. FoisH-Index: 17
#2Valentina ScanoH-Index: 4
Last. Angelo ZinelluH-Index: 31
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