Dale C. Leitman
University of California, Berkeley
Nuclear receptor coactivator 2Response elementEndocrinologyMolecular biologyRegulation of gene expressionEstrogen receptor alphaChemistryPsychological repressionEstrogenTamoxifenSelective estrogen receptor modulatorAgonistRaloxifeneCancer researchHormone response elementCoactivatorEstrogen receptorTranscription factorBiologyEstrogen receptor beta
47Publications
26H-index
3,150Citations
Publications 45
Newest
#1Kathryn M Benavidez (St. Edward's University)H-Index: 2
#2Colin A. ChapmanH-Index: 82
Last. Michael D. Wasserman (McGill University)H-Index: 14
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#2Tara R. HarrisH-Index: 11
Last. Jessica M. RothmanH-Index: 27
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#1Mary Tagliaferri (Bionovo, Inc.)H-Index: 23
#2Jennifer M. Creasman (UCSF: University of California, San Francisco)H-Index: 24
Last. Deborah Grady (UCSF: University of California, San Francisco)H-Index: 80
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Objective To evaluate the level of reduction in hot flushes among a cohort of postmenopausal women randomized to a phase-2 clinical trial evaluating MF101, a selective estrogen receptor β modulator, for treatment of vasomotor symptoms to determine clinically meaningful efficacy.Methods We performed a re-analysis of data from a double-blinded, placebo-controlled trial of 217 postmenopausal women randomized to treatment with MF101 or placebo for 12 weeks. At study termination, participants were as...
3 CitationsSource
#1Dale C. Leitman (University of California, Berkeley)H-Index: 26
#2Uwe Christians (University of Colorado Denver)H-Index: 51
Introduction: The Women's Health Initiative Estrogen Plus Progestin clinical trial demonstrated the risks exceeded the benefits which have led to a decline in menopausal hormone therapy (MHT) by greater than 50%. MHT use was initiated long before there was a significant understanding of the molecular mechanisms of estrogens. It has become clear that the problem with the current estrogens in MHT is they act non-selectively as an agonist in all tissues that contain estrogen receptors. MF101 is an ...
7 CitationsSource
#1Michael D. Wasserman (McGill University)H-Index: 14
#2Alexandra Taylor-Gutt (University of California, Berkeley)H-Index: 1
Last. Dale C. Leitman (University of California, Berkeley)H-Index: 26
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Phytoestrogens, or naturally occurring estrogen-mimicking compounds, are found in many human plant foods, such as soybeans (Glycine max) and other legumes. Because the consumption of phytoestro- gens may result in both health benefits of protecting against estrogen-dependent cancers and reproductive costs of disrupting the developing endocrine system, con- siderable biomedical research has been focused on the physiological and behavioral effects of these compounds. Despite this interest, little ...
16 CitationsSource
#1Dale C. LeitmanH-Index: 26
#2Sreenivasan Paruthiyil (Bionovo, Inc.)H-Index: 2
Last. Terence P. Speed (University of California, Berkeley)H-Index: 91
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Estrogens are frequently used in reproductive medicine. The Women’s Health Initiative trial found that the risks of menopausal hormone therapy (MHT) exceed the benefits. The estrogens in MHT, however, were introduced prior to our understanding of the mechanism of action of estrogens. Estrogen signaling is highly complex, involving various DNA regulatory elements to which estrogen receptors bind. Numerous transcription factors and co-regulatory proteins modify chromatin structure to further regul...
22 CitationsSource
#1Elise F. Saunier (Bionovo, Inc.)H-Index: 4
#2Omar I. Vivar (University of California, Berkeley)H-Index: 5
Last. Dale C. Leitman (University of California, Berkeley)H-Index: 26
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Long-term estrogen deficiency increases the risk of obesity, diabetes and metabolic syndrome in postmenopausal women. Menopausal hormone therapy containing estrogens might prevent these conditions, but its prolonged use increases the risk of breast cancer, as wells as endometrial cancer if used without progestins. Animal studies indicate that beneficial effects of estrogens in adipose tissue and adverse effects on mammary gland and uterus are mediated by estrogen receptor alpha (ERα). One strate...
9 CitationsSource
#1Aleksandra Cvoro (UCSF: University of California, San Francisco)H-Index: 6
#2Chaoshen Yuan (University of California, Berkeley)H-Index: 3
Last. Dale C. LeitmanH-Index: 26
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Glucocorticoids exert potent anti-inflammatory effects by repressing proinflammatory genes. We previously demonstrated that estrogens repress numerous proinflammatory genes in U2OS cells. The objective of this study was to determine if cross talk occurs between the glucocorticoid receptor (GR) and estrogen receptor (ER)α. The effects of dexamethasone (Dex) and estradiol on 23 proinflammatory genes were examined in human U2OS cells stably transfected with ERα or GR. Three classes of genes were re...
29 CitationsSource
#1Dale C. Leitman (University of California, Berkeley)H-Index: 26
#2Sreenivasan Paruthiyil (Bionovo, Inc.)H-Index: 2
Last. Terence P. Speed (University of California, Berkeley)H-Index: 91
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Estrogenic effects are mediated through two estrogen receptor (ER) subtypes, ERα and ERβ. Estrogens are the most commonly prescribed drugs to treat menopausal conditions, but by non-selectively triggering both ERα and ERβ pathways in different tissues they can cause serious adverse effects. The different sizes of the binding pockets and sequences of their activation function domains indicate that ERα and ERβ should have different specificities for ligands and biological responses that can be exp...
106 CitationsSource
#1Lili Zhang (UCSF: University of California, San Francisco)H-Index: 1
#2Brigitte E. Blackman (UCSF: University of California, San Francisco)H-Index: 5
Last. Dale C. Leitman (University of California, Berkeley)H-Index: 26
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Estrogens are used extensively to treat hot flashes in menopausal women. Some of the beneficial effects of estrogens in hormone therapy on the brain might be due to nongenomic effects in neurons such as the rapid stimulation of calcium oscillations. Most studies have examined the nongenomic effects of estrogen receptors (ER) in primary neurons or brain slices from the rodent brain. However, these cells can not be maintained continuously in culture because neurons are post-mitotic. Neurons derive...
20 CitationsSource
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