Akitaka Tsujikawa
Kyoto University
OphthalmologyInternal medicineSurgerySingle-nucleotide polymorphismMacular degenerationRetinaRetinal pigment epitheliumVisual acuityGlaucomaOptical coherence tomographyFluorescein angiographyBranch retinal vein occlusionMacular edemaRetinalRanibizumabChoroidal neovascularizationOptical coherence tomography angiographyAge relatedMedicineBiology
423Publications
60H-index
8,009Citations
Publications 430
Newest
#1Yuichiro Shimizu (Kyoto University)H-Index: 1
#2Manabu Miyata (Kyoto University)H-Index: 13
Last. Ayako Takahashi (Kyoto University)H-Index: 16
view all 14 authors...
PURPOSE To investigate whether the efficacy of anti-vascular endothelial growth factor (VEGF) monotherapy for polypoidal choroidal vasculopathy (PCV) differs between pachychoroid and non-pachychoroid phenotypes in the long term. METHODS This retrospective longitudinal study included 115 treatment-naive eyes in 115 consecutive patients with symptomatic PCV who were treated with anti-VEGF monotherapy and were followed up for 5 years. Eligible eyes were assigned to either a pachy-PCV group, with a ...
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#1Yoko Okamoto (Kyoto University)H-Index: 21
#2Tadamichi Akagi (Niigata University)H-Index: 30
Last. Akitaka Tsujikawa (Kyoto University)H-Index: 60
view all 10 authors...
We performed a prospective, longitudinal study to investigate the association between the preoperative intrascleral vasculature assessed using anterior segment (AS)-optical coherence tomography angiography (OCTA) and surgical outcomes of trabecular meshwork-targeted micro- or minimally invasive glaucoma surgery (MIGS). We included 37 patients with primary open-angle glaucoma. Preoperative AS-OCTA images of the sclero-conjunctiva of the nasal corneal limbus were acquired in the superficial (conju...
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#1Kenji Yamashiro (Kyoto University)H-Index: 61
#2Akio Oishi (Nagasaki University)H-Index: 38
Last. Akitaka Tsujikawa (Kyoto University)H-Index: 60
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Anti-VEGF treatment for neovascular age-related macular degeneration (nAMD) has been evaluated in clinical trials. To select the best anti-VEGF drug and the best treatment regimen for nAMD, a thorough understanding of the characteristics of each anti-VEGF drug and treatment regimen is essential. In this review, we summarized visual acuity (VA) changes in 30 previous clinical trials of anti-VEGF treatment for nAMD. In most studies, ranibizumab, aflibercept, and brolucizumab improved the VA by 6 t...
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#1Miho Tagawa (Kyoto University)H-Index: 2
#2Hanako Ohashi Ikeda (Kyoto University)H-Index: 19
Last. Akitaka Tsujikawa (Kyoto University)H-Index: 60
view all 6 authors...
We have established a stepwise method to differentiate induced pluripotent stem cells (iPSCs) into retinal pigment epithelium (RPE) (iPSC-RPE), which enables efficient isolation and purification of patient-derived iPSC-RPE cells with high quality. Here, we describe in detail the process of differentiating iPSCs into iPSC-RPE.
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#1Shin Kadomoto (Kyoto University)H-Index: 4
#2Yuki Muraoka (Kyoto University)H-Index: 19
Last. Akitaka Tsujikawa (Kyoto University)H-Index: 60
view all 9 authors...
Purpose The purpose of this study was to image and investigate the foveal microstructure of human cone and Muller cells using adaptive optics-optical coherence tomography. Methods Six healthy subjects underwent the prototype adaptive optics-optical coherence tomography imaging, which allowed an axial resolution of 3.4 µm and a transverse resolution of approximately 3 µm. The morphological features of the individual retinal cells observed in the foveola were qualitatively and quantitatively evalu...
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#1Ayaka Doi (Kyoto University)
#2Manabu Miyata (Kyoto University)H-Index: 13
Last. Akitaka Tsujikawa (Kyoto University)H-Index: 60
view all 12 authors...
PURPOSE To investigate long-term visual outcome in inferior posterior staphyloma (IPS) in each group classified based on macular complications and to examine the treatment effect for eyes with IPS with choroidal neovascularization (CNV) DESIGN: Prospective clinical cohort study PARTICIPANTS: We analyzed 56 eyes of 43 consecutive patients with IPS who were followed for 4 years. METHODS We classified eligible eyes into three groups based on baseline findings: eyes without CNV or retinal exudate (n...
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#1Ai Kido (Kyoto University)H-Index: 3
#2Masahiro Miyake (Kyoto University)H-Index: 27
Last. Akitaka Tsujikawa (Kyoto University)H-Index: 60
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To investigate the association between the use of topical β-blockers and subsequent asthma attacks in glaucoma patients with asthma. This was a retrospective longitudinal cohort study using an administrative claims database. All patients aged 20 years or older who were registered in the health insurance claims database updated and managed by JMDC Inc. (Tokyo, Japan). Patients who were newly prescribed eye drops for glaucoma treatment were identified between 2011 and 2017. The patients with glauc...
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#1Sachiko Iwai (Kyoto University)H-Index: 5
#2Hanako Ohashi Ikeda (Kyoto University)H-Index: 19
Last. Akira Kakizuka (Kyoto University)H-Index: 60
view all 7 authors...
Currently there is no effective treatment available for osteoarthritis (OA). We have recently developed Kyoto University Substances (KUSs), ATPase inhibitors specific for valosin-containing protein (VCP), as a novel class of medicine for cellular protection. KUSs suppressed intracellular ATP depletion, endoplasmic reticulum (ER) stress, and cell death. In this study, we investigated the effects of KUS121 on chondrocyte cell death. In cultured chondrocytes differentiated from ATDC5 cells, KUS121 ...
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#1Kentaro Kawai (Kyoto University)H-Index: 2
#2Akihito UjiH-Index: 25
Last. Akitaka TsujikawaH-Index: 60
view all 10 authors...
PURPOSE To investigate the effect of denoise processing by artificial intelligence (AI) on the optical coherence tomography angiography (OCTA) images in eyes with retinal lesions. METHODS Prospective, observational, cross-sectional study. OCTA imaging of a 3 x 3 mm area involving the lesions (neovascularization, intraretinal microvascular abnormality, and non-perfusion area) was performed five times using OCT-HS100 (Canon, Tokyo, Japan). We acquired AI-denoised OCTA images and averaging OCTA ima...
1 CitationsSource
#1Shin Kadomoto (Kyoto University)H-Index: 4
#2Yuki Muraoka (Kyoto University)H-Index: 19
Last. Akitaka Tsujikawa (Kyoto University)H-Index: 60
view all 6 authors...
Abstract null null High resolution imaging with optical coherence tomography angiography and offset pinhole adaptive optics scanning light ophthalmoscope helped us visualize the hemodynamic and structural changes in a ruptured retinal arterial macroaneurysm in a 78-year-old woman. Intravitreal injection of anti-vascular endothelial growth factor was administered to ameliorate the condition.
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