Estelle Oberlin
French Institute of Health and Medical Research
CD34HaematopoiesisAmniotic stem cellsEndothelial stem cellInternal medicineEndocrinologyAmniotic epithelial cellsPathologyEmbryonic stem cellMesenchymal stem cellProgenitor cellStem cell factorImmunologyAdult stem cellEx vivoEndotheliumYolk sacHematonBone marrowVE-cadherinStem cellPopulationOntogenyBiologyImmune systemCell biologyHemangioblast
22Publications
7H-index
630Citations
Publications 18
Newest
#1Yu Y (Peking Union Medical College)H-Index: 1
#2Valderrama Av (French Institute of Health and Medical Research)H-Index: 1
Last. Estelle Oberlin (French Institute of Health and Medical Research)H-Index: 7
view all 6 authors...
Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or modulate deleterious immune responses by various molecular mechanisms. These cells are the subject of major translational efforts as cellular therapies for immune-related diseases and transplantations. Plenty of preclinical studies and clinical trials employing MSCs have shown promising safety and efficacy outcomes and also shed light on the modifications in the frequency and function of regulatory T cells (T regs). Neverthele...
1 CitationsSource
#1Yanyan Zhang (French Institute of Health and Medical Research)H-Index: 11
#2Denis Clay (French Institute of Health and Medical Research)H-Index: 26
Last. Estelle Oberlin (French Institute of Health and Medical Research)H-Index: 7
view all 9 authors...
Despite advances to engineer transplantable hematopoietic stem and progenitor cells (HSPCs) for research and therapy, an in-depth characterization of the developing human hematopoietic system is st...
3 CitationsSource
#1Ye Fan (French Institute of Health and Medical Research)H-Index: 2
#2Florence Herr (French Institute of Health and Medical Research)H-Index: 3
Last. Antoine Durrbach (University of Paris-Sud)H-Index: 56
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Mesenchymal stem cells (MSCs) are powerful immunomodulators that regulate the diverse functions of immune cells involved in allogeneic reactions, such as T cells and natural killer (NK) cells, thro...
29 CitationsSource
#1Estelle Oberlin (French Institute of Health and Medical Research)H-Index: 7
#2Yanyan Zhang (French Institute of Health and Medical Research)H-Index: 11
Last. Annelise Bennaceur-Griscelli (French Institute of Health and Medical Research)H-Index: 20
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Despite advances to engineer transplantable hematopoietic stem and progenitor cells (HSPCs) for research and therapy, an in depth characterization of the developing human hematopoietic system is still lacking. The human embryonic liver is at the crossroad of several hematopoietic sites and harbours a complex hematopoietic hierarchy including the first, actively dividing, HSPCs that will further seed the definitive hematopoietic organs. However few is known about the hierarchical phenotypic and f...
Source
#1Estelle Oberlin (University of Paris-Sud)H-Index: 7
#2Maud Fleury (University of Paris-Sud)H-Index: 4
Last. Michèle Souyri (University of Paris-Sud)H-Index: 18
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Edification of the human hematopoietic system during development is characterized by the production of waves of hematopoietic cells separated in time, formed in distinct embryonic sites (ie, yolk sac, truncal arteries including the aorta, and placenta). The embryonic liver is a major hematopoietic organ wherein hematopoietic stem cells (HSCs) expand, and the future, adult-type, hematopoietic cell hierarchy becomes established. We report herein the identification of a new, transient, and rare cel...
39 CitationsSource
#1Estelle Oberlin (French Institute of Health and Medical Research)H-Index: 7
#2Bouchra El HafnyH-Index: 3
Last. Michèle SouyriH-Index: 18
view all 4 authors...
Hematopoietic stem cells (HSCs) arise first in the third week of human ontogeny inside yolk sac developing blood vessels, and independently, from the wall of the embryonic aorta and vitelline arteries one week later. HSCs produced in the yolk sac and in the embryonic truncal arteries migrate to and transiently colonize the embryonic liver (EL), and thereafter the bone marrow (BM), their permanent site of residence. At the moment, the origin of human HSCs is still controversial; one of the main h...
34 CitationsSource
#1Elias T. Zambidis (Johns Hopkins University)H-Index: 30
#2Estelle Oberlin (Johns Hopkins University)H-Index: 7
Last. Bruno Péault (Johns Hopkins University)H-Index: 74
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During the early weeks of human gestation, hematopoietic cells first emerge within the extraembryonic yolk sac (primitive hematopoiesis) and secondarily within the truncal arteries of the embryo. This second wave includes the stem cells giving rise to adult-type lymphohematopoiesis. In both yolk sac blood islands and embryonic aorta, hematopoietic cells arise in the immediate vicinity of vascular endothelial cells. In vitro hematopoietic differentiation of endothelial cells stringently sorted fr...
45 CitationsSource
#1I BlazsekH-Index: 3
#2Estelle OberlinH-Index: 7
Last. Bruno Péault (Edin.: University of Edinburgh)H-Index: 74
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#1Manuela Tavian (French Institute of Health and Medical Research)H-Index: 24
#2Bo Zheng (University of Pittsburgh)H-Index: 14
Last. Bruno Péault (French Institute of Health and Medical Research)H-Index: 74
view all 7 authors...
We have characterized the emerging hematopoietic system in the human embryo and fetus. Two embryonic organs, the yolk sac and aorta, sup- port the primary emergence of hematopoietic stem cells (HSCs), but only the latter contributes lymphomyeloid stem cells for definitive, adult-type hemato- poiesis. A common feature of intra- and extraembryonic hematopoiesis is that in both locations hematopoietic cells emerge in close vicinity to vascular endo- thelial cells. We have provided evidence that a p...
119 CitationsSource
#1Manuela TavianH-Index: 24
#2Bo ZhengH-Index: 1
Last. Bruno Péault (Edin.: University of Edinburgh)H-Index: 74
view all 7 authors...