Peter C. M. Molenaar
Queensland University of Technology
StatisticsInternal medicineEndocrinologyDevelopmental psychologyEconometricsArtificial intelligencePsychologyCardiologyReceptorChemistryAcetylcholineNeuromuscular junctionMyasthenia gravisMathematicsAdrenergic receptorComputer scienceMedicineAcetylcholine receptorBiologyPharmacology
Publications 579
#1M. Wells (Griffith University)H-Index: 3
#2Louise E. See Hoe (UQ: University of Queensland)H-Index: 12
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Abstract Background Heart failure is an inexorably progressive disease with a high mortality, for which heart transplantation (HTx) remains the gold standard treatment. Currently, donor hearts are primarily derived from patients following brain stem death (BSD). BSD causes activation of the sympathetic nervous system, increases endothelin levels, and triggers significant inflammation that together with potential myocardial injury associated with the transplant procedure, may affect contractility...
#1Abimbola J. Aminu (University of Manchester)H-Index: 1
#2Maria Petkova (University of Manchester)H-Index: 3
Last. Halina Dobrzynski (University of Manchester)H-Index: 47
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Abstract Research purpose The sinus node (SN) is the heart's primary pacemaker. Key ion channels (mainly the funny channel, HCN4) and Ca2+-handling proteins in the SN are responsible for its function. Transcription factors (TFs) regulate gene expression through inhibition or activation and microRNAs (miRs) do this through inhibition. There is high expression of macrophages and mast cells within the SN connective tissue. ‘Novel’/unexplored TFs and miRs in the regulation of ion channels and immune...
1 CitationsSource
#1Lisa L. Harlow (URI: University of Rhode Island)H-Index: 2
#1Lisa L. Harlow (URI: University of Rhode Island)H-Index: 1
Last. Stephen G. West (ASU: Arizona State University)H-Index: 88
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Wayne Velicer is remembered for a mind where mathematical concepts and calculations intrigued him, behavioral science beckoned him, and people fascinated him. Born in Green Bay, Wisconsin o...
1 CitationsSource
#1A. Dashwood (UQ: University of Queensland)H-Index: 2
#2Elizabeth Cheesman (UQ: University of Queensland)H-Index: 1
Last. Peter C. M. Molenaar (QUT: Queensland University of Technology)H-Index: 86
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Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically; contractile dynamics, interaction with the β1 -adrenoceptor (AR) agonist (-)-noradrenaline and spontaneous contractions. Left and right ventricular trabeculae from 13 explanted failing hearts, and trabeculae from 58 right atrial appendages of non-failing...
1 CitationsSource
#1Kelly A. Duffy (UMN: University of Minnesota)
#1Kelly A. Duffy (UMN: University of Minnesota)H-Index: 3
Last. Kathleen M. Gates (UNC: University of North Carolina at Chapel Hill)H-Index: 22
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Introduction. Group iterative multiple model estimation (GIMME) has proven to be a reliable data-driven method to arrive at functional connectivity maps that represent associations between brain regions across time in groups and individuals. However, to date, GIMME has not been able to model time-varying task-related effects. This paper introduces HRF-GIMME, an extension of GIMME that enables the modeling of the direct and modulatory effects of a task on fMRI data collected using event-related d...
#1Xiao Yang (Stanford University)H-Index: 14
#2Nilam Ram (Stanford University)H-Index: 55
Last. Pamela M. Cole (PSU: Pennsylvania State University)H-Index: 32
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We introduce a discrete-time dynamical system method, the Boolean network method, that may be useful for modeling, studying, and controlling nonlinear dynamics in multivariate systems, particularly when binary time-series are available. We introduce the method in three steps: inference of the temporal relations as Boolean functions, extraction of attractors and assignment of desirability based on domain knowledge, and design of network control to direct a psychological system toward a desired at...
#1L. See HoeH-Index: 2
#2Karin WildiH-Index: 35
Last. John F. FraserH-Index: 60
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Purpose Cold static storage (CSS) is the standard method for heart preservation during transplantation (HTx). However, CSS beyond 4 hours increases the risk of primary graft dysfunction (PGD). Hypothermic ex vivo perfusion (HEVP) of donor hearts allows oxygen delivery during preservation, and may facilitate extended donor preservation without increasing PGD risk. We compared post-HTx survival, systemic inflammation and cardiac function following donor heart preservation by CSS (2 hrs) versus HEV...
#1Michael N. Hallquist (PSU: Pennsylvania State University)H-Index: 34
#2Aidan G. C. Wright (University of Pittsburgh)H-Index: 56
Last. Peter C. M. Molenaar (PSU: Pennsylvania State University)H-Index: 86
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AbstractUnderstanding patterns of symptom co-occurrence is one of the most difficult challenges in psychopathology research. Do symptoms co-occur because of a latent factor, or might they directly ...
27 CitationsSource
#1M. WellsH-Index: 3
#2Louise E. See HoeH-Index: 12
Last. John F. FraserH-Index: 60
view all 8 authors...
Primary graft dysfunction (PGD) is an important cause of morbidity and mortality after cardiac transplantation. Donor brain stem death (BSD) is a significant contributor to donor heart dysfunction (DHD) and PGD. There remain substantial gaps in the mechanistic understanding of peritransplant cardiac dysfunction. One of these gaps is cardiac metabolism and metabolic function. The healthy heart is an ‘omnivore’, capable of utilising multiple sources of nutrients to fuel its enormous energetic dema...
1 CitationsSource
#1Santiago Pineda (DI: Discovery Institute)H-Index: 2
#2Vesna Nikolova-Krstevski (VCCRI: Victor Chang Cardiac Research Institute)H-Index: 13
Last. Magdalena Soka (VCCRI: Victor Chang Cardiac Research Institute)H-Index: 3
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BACKGROUND KCNMA1 encodes the α-subunit of the large-conductance Ca2+-activated K+ channel, KCa1.1, and lies within a linkage interval for atrial fibrillation (AF). Insights into the cardiac functions of KCa1.1 are limited, and KCNMA1 has not been investigated as an AF candidate gene. METHODS The KCNMA1 gene was sequenced in 118 patients with familial AF. The role of KCa1.1 in normal cardiac structure and function was evaluated in humans, mice, zebrafish, and fly. A novel KCNMA1 variant was func...