Gerald M. Reaven
Stanford University
Internal medicineEndocrinologyChemistryType 2 diabetesInsulin resistanceGlucose uptakeCholesterolTriglycerideInsulinLipoproteinBody mass indexPancreatic hormoneGlucose tolerance testHyperinsulinemiaPopulationObesityDiabetes mellitusMedicineBlood pressureBiology
Publications 703
#1Mohsen Fathzadeh (Cardiovascular Institute of the South)H-Index: 9
#2Jiehan Li (Cardiovascular Institute of the South)H-Index: 7
Last. Joshua W. Knowles (Cardiovascular Institute of the South)H-Index: 53
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Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A i...
7 CitationsSource
#1Henry N. GinsbergH-Index: 118
#2Jerrold M. OlefskyH-Index: 158
Last. Gerald M. ReavenH-Index: 148
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Abstract Moderate amounts of ethanol were given three times daily for 7 days to nonalcoholic normal persons and hypertriglyceridemic persons, and plasma lipid, glucose, and insulin levels were meas...
#1Shoa L. Clarke (Stanford University)H-Index: 7
#2Gerald M. Reaven (Stanford University)H-Index: 148
Last. David J. Maron (Stanford University)H-Index: 52
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Abstract Background Insulin resistance may be present in healthy adults and is associated poor health outcomes. Obesity is a risk factor for insulin resistance, but most obese adults do not have insulin resistance. Fitness may be protective, but the association between fitness, weight, and insulin resistance has not been studied in a large population of healthy adults. Methods A cross-sectional analysis of cardiorespiratory fitness, body-mass index, and markers of insulin resistance was performe...
3 CitationsSource
#1Viraj Raygor (Stanford University)H-Index: 2
#2Fahim Abbasi (Stanford University)H-Index: 60
Last. Joshua W. Knowles (Stanford University)H-Index: 53
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Objective:Insulin sensitivity affects plasma triglyceride concentration and both differ by race/ethnicity. The purpose of this study was to provide a comprehensive assessment of the variation in in...
8 CitationsSource
#1Michael H. Dahan (McGill University)H-Index: 20
#2Gerald M. Reaven (Stanford University)H-Index: 148
Purpose To evaluate the relationship between obesity and insulin resistance among women with polycystic ovary syndrome (PCOS) using a gold standard test.
9 CitationsSource
#1Fahim Abbasi (Stanford University)H-Index: 60
#2Paul Tern (University of Cambridge)H-Index: 2
Last. Gerald M. Reaven (Stanford University)H-Index: 148
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Aim:The aim of this study was to gain insight into the pathophysiological significance of elevated plasma glucose concentrations (mmol/L) 60 min post oral glucose load in apparently healthy individuals.Methods:Comparison of resistance to insulin action and associated cardio-metabolic risk factors in 490 apparently healthy persons, subdivided into those with a plasma glucose concentration 60 min following a 75-g oral glucose challenge of <8.6 versus ⩾8.6.Results:Insulin resistance was significant...
2 CitationsSource
#1Michael H. Dahan (McGill University)H-Index: 20
#2Fahim Abbasi (Stanford University)H-Index: 60
Last. Gerald M. Reaven (Stanford University)H-Index: 148
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Purpose To evaluate the relationship between surrogate estimates of insulin resistance and a direct measurement of insulin-mediated glucose uptake women with and without PCOS.
9 CitationsSource
#1Lars Lind (Uppsala University)H-Index: 134
#2Erik Ingelsson (Stanford University)H-Index: 124
Last. Gerald M. Reaven (Stanford University)H-Index: 148
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Abstract Background: The plasma concentration ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL-C ratio as a simple clinical way to identify apparently healthy individuals with insulin resistance and enhanced risk of future cardiovascular disease (CVD). Methods: One thousand seven hundred twenty men, aged 50 years, free from diabetes and CVD when evaluated at baseline in 1970–1974 were followed ...
4 CitationsSource
#1Anna K. Poon (UNC: University of North Carolina at Chapel Hill)H-Index: 7
#2Michelle L. Meyer (UNC: University of North Carolina at Chapel Hill)H-Index: 12
Last. Gerardo Heiss (UNC: University of North Carolina at Chapel Hill)H-Index: 141
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Context: The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies; however, their short-term repeatability is not well characterized. Objective: To quantify the short-term repeatability of insulin resistance indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR and TG and HDL-C for TG/HDL-C. ...
7 CitationsSource
#1Sang-Hee JungH-Index: 1
#2Chan-Hee Jung (SCH: Soonchunhyang University)H-Index: 2
Last. Sun H. Kim (Stanford University)H-Index: 23
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Aims/hypothesis The aim of this study was to quantify the relative contributions of increased insulin secretion rate (ISR) and decreased insulin clearance rate (ICR) in the compensatory hyperinsulinaemia characteristic of insulin-resistant individuals without diabetes.
35 CitationsSource