Emanuele Di Angelantonio
University of Cambridge
Genome-wide association studyInternal medicineEndocrinologyOdds ratioCardiologyProspective cohort studyHazard ratioCholesterolHeart failureDiseaseBody mass indexPopulationConfidence intervalRisk factorStrokeGeneticsDiabetes mellitusMedicineBiologyMeta-analysis
Publications 231
Abstract null null Clinical estimation of the combined effect of several risk factors is unreliable and this resulted in the development of a number of risk estimation systems to guide clinical practice. Here, after defining general principles of risk estimation, the authors describe the evolution of the European Society of Cardiology’s (ESC) Systematic COronary Risk Evaluation (SCORE) risk estimation system and some learnings from the data. They move on to describe the establishment of the ESC’...
#2Rory P. WilsonH-Index: 72
Last. Pascal Schlosser (University of Freiburg)H-Index: 7
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BACKGROUND Studies on the relationship between renal function and the human plasma proteome have identified several potential biomarkers. However, investigations have been conducted largely in European populations, and causality of the associations between plasma proteins and kidney function has never been addressed. METHODS A cross-sectional study of 993 plasma proteins among 2,882 participants in four studies of European and admixed ancestries (KORA, INTERVAL, HUNT, QMDiab) identified trans-et...
#3Steven H J HagemanH-Index: 3
#4Lisa PennellsH-Index: 16
Last. Frank KeeH-Index: 76
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2 CitationsSource
#3Tamar I. de VriesH-Index: 4
Last. Zhe XuH-Index: 2
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2 CitationsSource
#9Andre Charlett (PHE: Public Health England)H-Index: 41
Abstract null null Background null SARS-CoV-2 antibody tests are used for population surveillance and might have a future role in individual risk assessment. Lateral flow immunoassays (LFIAs) can deliver results rapidly and at scale, but have widely varying accuracy. null null null Methods null In a laboratory setting, we performed head-to-head comparisons of four LFIAs: the Rapid Test Consortium's AbC-19TM Rapid Test, OrientGene COVID IgG/IgM Rapid Test Cassette, SureScreen COVID-19 Rapid Test ...
#1Karina W. Davidson (The Feinstein Institute for Medical Research)H-Index: 89
#2Lisa Pennells (University of Cambridge)H-Index: 16
Last. Emanuele Di Angelantonio (University of Cambridge)H-Index: 70
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#1Gaziano L (University of Cambridge)H-Index: 1
#2Claudia Giambartolomei (IIT: Istituto Italiano di Tecnologia)H-Index: 22
Last. Juan P. Casas (Brigham and Women's Hospital)H-Index: 80
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Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics from the Host Genetics Initiative and the Million Veteran Program, we studied 7,554 patie...
#1Steven Bell (University of Cambridge)H-Index: 21
#2Michael J. Sweeting (University of Cambridge)H-Index: 50
Last. Emanuele Di Angelantonio (University of Cambridge)H-Index: 70
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OBJECTIVE To compare four haemoglobin measurement methods in whole blood donors. BACKGROUND To safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant's (NHSBT) customary method have been capillary gravimetry (copper sulphate), followed by venous spectrophotometry (HemoCue) for donors failing gravimetry. However, NHSBT's customary method results in 10% of donors being inappropriately bled (ie, with haemoglobin values below the regu...
1 CitationsSource
#1CoddH-Index: 2
#1Veryan CoddH-Index: 1
Last. Nilesh J. Samani (University of Leicester)H-Index: 154
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Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture of naturally-occurring variation in leucocyte telomere length (LTL) and identify causal links between LTL and biomedical phenotypes in 472,174 well-characterized participants in UK Biobank. We identified 197 independent sentinel variants associated with LTL at 138 genomic loci (108 novel). Genetically-determined differences in LTL were associated wit...
1 CitationsSource
#1Wang QH-Index: 2
#2CoddH-Index: 2
Last. Christopher P. NelsonH-Index: 68
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BackgroundOlder chronological age is the most powerful risk factor for adverse coronavirus disease-19 (COVID-19) outcomes. It is uncertain, however, whether older biological age, as assessed by leucocyte telomere length (LTL), is also associated with COVID-19 outcomes. MethodsWe associated LTL values obtained from participants recruited into UK Biobank (UKB) during 2006-2010 with adverse COVID-19 outcomes recorded by 30 November 2020, defined as a composite of any of the following: hospital admi...