Christine Ecker
Goethe University Frankfurt
NeuroanatomyPsychiatryDevelopmental psychologyPsychologyNeuroscienceCognitionCognitive psychologyAutismNeurotypicalAutism spectrum disorderFunctional magnetic resonance imagingAttention deficit hyperactivity disorderWhite matterPrefrontal cortexBrain mappingAudiologyNeuroimagingClinical psychologyMedicineBiology
149Publications
43H-index
5,591Citations
Publications 118
Newest
#1Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
#2Isotta Landi (IIT: Istituto Italiano di Tecnologia)
Last. Michael V. Lombardo (University of Cambridge)H-Index: 56
view all 35 authors...
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC >...
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#1Zhiqiang Sha (MPG: Max Planck Society)H-Index: 1
#2van Rooij D (Radboud University Nijmegen)
Last. Clyde Francks (MPG: Max Planck Society)H-Index: 57
view all 59 authors...
Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls. Although these alterations affect multiple and widespread cortical regional asymmetries, the extent to which specific structural networks might be affected remains unknown. Inter-regional morphological covariance analysis can capture network connectivity relations between different cortical areas at t...
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#1Emily Olafson (Douglas Mental Health University Institute)
#1Emily Olafson (Cornell University)H-Index: 1
Last. M. Mallar Chakravarty (Douglas Mental Health University Institute)H-Index: 67
view all 26 authors...
Autism spectrum disorder (ASD) is associated with atypical brain development. However, the phenotype of regionally specific increased cortical thickness observed in ASD may be driven by several independent biological processes that influence the gray/white matter boundary, such as synaptic pruning, myelination, or atypical migration. Here, we propose to use the boundary sharpness coefficient (BSC), a proxy for alterations in microstructure at the cortical gray/white matter boundary, to investiga...
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#1Caroline Mann (Goethe University Frankfurt)H-Index: 3
#2Tim Schäfer (Goethe University Frankfurt)H-Index: 4
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 13 authors...
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is accompanied by neurodevelopmental differences in regional cortical volume (CV), and a potential layer-specific pathology. Conventional measures of CV, however, do not indicate how volume is distributed across cortical layers. In a sample of 92 typically developing (TD) controls and 92 adult individuals with ASD (aged 18-52 years), we examined volumetric gradients by quantifying the degree to which CV is weighted from...
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#1Robert Wichers ('KCL': King's College London)H-Index: 5
#2James Findon ('KCL': King's College London)H-Index: 8
Last. Eileen Daly ('KCL': King's College London)H-Index: 65
view all 13 authors...
Background Autism spectrum disorder (ASD) is associated with deficits in executive functioning (EF), and these have been suggested to contribute to core as well as co-occurring psychiatric symptoms. The biological basis of these deficits is unknown but may include the serotonergic system, which is involved both in regulating EF in neurotypical populations and in the pathophysiology of ASD. We previously demonstrated that reducing serotonin by acute tryptophan depletion (ATD) shifts differences i...
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#1Anke Bletsch (Goethe University Frankfurt)H-Index: 3
#2Tim Schäfer (Goethe University Frankfurt)H-Index: 4
Last. Crispian WilsonH-Index: 2
view all 39 authors...
Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently in vivo neuroimaging studies converge in suggesting that neuroanatomical abnormalities, specifically around the gray-white matter (GWM) boundary, represent a crucial feature of ASD. However, no research has yet characterized the GWM boundary in ASD based on measures of di...
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#1Tim Schäfer (Goethe University Frankfurt)H-Index: 4
#2Caroline Mann (Goethe University Frankfurt)H-Index: 3
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 7 authors...
Zusammenfassung. Theoretischer Hintergrund: Autismus-Spektrum-Storung (ASS) ist eine neuronale Entwicklungsstorung und tritt haufig gemeinsam mit der Aufmerksamkeitsdefizit-/Hyperaktivitatsstorung ...
1 CitationsSource
#1Christina Luckhardt (Goethe University Frankfurt)H-Index: 2
#2Magdalena Schütz (Goethe University Frankfurt)H-Index: 2
Last. Christine M. Freitag (Goethe University Frankfurt)H-Index: 71
view all 16 authors...
BACKGROUND Autism spectrum disorder (ASD) is characterized by impaired social communication and interaction, and stereotyped, repetitive behaviour and sensory interests. To date, there is no effective medication that can improve social communication and interaction in ASD, and effect sizes of behaviour-based psychotherapy remain in the low to medium range. Consequently, there is a clear need for new treatment options. ASD is associated with altered activation and connectivity patterns in brain a...
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#1Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
#2Isotta Landi (IIT: Istituto Italiano di Tecnologia)
Last. Michael V. Lombardo (University of Cambridge)H-Index: 56
view all 35 authors...
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (97-99%) out-of-sample SC=RRB, SC>RRB,...
Source
#1Maria Gudbrandsen ('KCL': King's College London)H-Index: 11
#2Eileen Daly ('KCL': King's College London)H-Index: 65
Last. Christine Ecker ('KCL': King's College London)H-Index: 43
view all 12 authors...
22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion in humans, with a heterogenous clinical presentation including medical, behavioural and psychiatric conditions. Previous neuroimaging studies examining the neuroanatomical underpinnings of 22q11.2DS show alterations in cortical volume (CV), cortical thickness (CT) and surface area (SA). The aim of this study was to identify (1) the spatially distributed networks of differences in CT and SA in 22q11.2DS compared to controls, (...
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