Saeed Samarghandian
Mashhad University of Medical Sciences
CancerInternal medicineEndocrinologymicroRNAChemistryApoptosisNeuroprotectionOxidative stressInflammationAntioxidantCurcuminMetastasisThymoquinoneDiseaseCancer researchGlutathioneDiabetes mellitusTraditional medicineCell growthSignal transductionMedicineBiologyCancer cellPharmacology
155Publications
19H-index
1,182Citations
Publications 161
Newest
#1Saeed SamarghandianH-Index: 19
#2Farshad Shirazi (UA: University of Arizona)H-Index: 13
Last. Omid Mehrpour (Birjand University of Medical Sciences)H-Index: 25
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Lead is one of the most toxic heavy metals in the environment. The present review aimed to highlight hazardous pollution sources, management, and review symptoms of lead poisonings in various parts of the world. The present study summarized the information available from case reports and case series studies from 2009 to March 2020 on the lead pollution sources and clinical symptoms. All are along with detoxification methods in infants, children, and adults. Our literature compilation includes re...
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#1Aliabbas Zia (UT: University of Tehran)H-Index: 2
#2Faezeh Sahebdel (UMN: University of Minnesota)
Last. Saeed SamarghandianH-Index: 19
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Abstract null null Sirtuin-1 (SIRT1) as a NAD + -dependent Class III protein deacetylase, involves in longevity and various cellular physiological processes. SIRT1 via deacetylating transcription factors regulates cell growth, inflammation, metabolism, hypoxic responses, cell survival, senescence, and aging. MicroRNAs (miRNAs) are short non-coding RNAs that modulate the expression of target genes in a post-transcriptional manner. Recent investigations have exhibited that miRNAs have an important...
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#1Ali Mohammad Pourbagher-Shahri (Birjand University of Medical Sciences)H-Index: 5
#2Tahereh Farkhondeh (Birjand University of Medical Sciences)H-Index: 22
Last. Jurga Bernatoniene (Lithuanian University of Health Sciences)H-Index: 19
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Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. T...
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#1Milad Ashrafizadeh (Sabancı University)H-Index: 9
#2Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
Last. Amir R. Aref (Harvard University)H-Index: 26
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Abstract null null An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Can...
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#1Marjan Talebi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 3
#2Mohsen Talebi (UTA: University of Texas at Arlington)H-Index: 10
Last. Saeed SamarghandianH-Index: 19
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Neurological diseases are responsible for a large number of morbidities and mortalities in the world. Flavonoids are phytochemicals that possess various health-promoting impacts. Chrysin, a natural flavonoid isolated from diverse fruits, vegetables, and even mushrooms, has several pharmacological activities comprising antioxidant, anti-inflammatory, antiapoptotic, anticancer, and neuroprotective effects. The current study was designed to review the relationship between chrysin administration and...
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#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
#2Asal Jalal Abadi (IAU: Islamic Azad University)H-Index: 2
Last. Haroon Khan (AWKUM: Abdul Wali Khan University Mardan)H-Index: 34
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Considering the fact that cancer cells can switch among various molecular pathways and mechanisms to ensure their progression, chemotherapy is no longer effective enough in cancer therapy. As an anti-tumor agent, doxorubicin (DOX) is derived from Streptomyces peucetius and can induce cytotoxicity by binding to topoisomerase enzymes to suppress DNA replication, leading to apoptosis and cell cycle arrest. However, efficacy of DOX in suppressing cancer progression is restricted by development of dr...
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#1Marjan Talebi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 3
Last. Saeed SamarghandianH-Index: 19
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Alzheimer's disease (AD) is a brain-linked pathophysiological condition with neuronal degeneration, cognition dysfunctions, and other debilitations. Due to the growing prevalence of AD, there is a highly commended tendency to accelerate and develop analytical technologies for easy, cost-effective, and sensitive detection of AD biomarkers. In the last decade, remarkable advancements have been achieved on the gate to the progression of biosensors, predominantly optical and electrochemical, to dete...
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#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
#2Mohammad Hossein Gholami (IAU: Islamic Azad University)H-Index: 3
Last. Haroon Khan (AWKUM: Abdul Wali Khan University Mardan)H-Index: 34
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As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative of CA isolated from propolis. This medicinal plant is well-known due to its significant therapeutic impact including its effectiveness as hepatoprotective, neuroprotective and anti-diabetic agent. Among them, anti-tumor activity of CA has attracted much attention, and this potential has been confirmed both in vit...
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#1Milad Ashrafizadeh (Sabancı University)H-Index: 9
#2Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
Last. Kiavash Hushmandi (UT: University of Tehran)H-Index: 10
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Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells are transformed to mesenchymal cells, and at molecular level, E-cadherin undergoes down-regulation, while an increase occurs in N-cadherin and vimentin levels. Increasing evidence demonstrates role of EMT in mediating drug resistance of cancer cells. On the other hand, paclitaxel (PTX) and docetaxel (DTX) are two chem...
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Aging is the leading risk factor for several age-associated diseases such as neurodegenerative diseases. Understanding the biology of aging mechanisms is essential to the pursuit of brain health. In this regard, brain aging is defined by a gradual decrease in neurophysiological functions, impaired adaptive neuroplasticity, dysregulation of neuronal Ca2+ homeostasis, neuroinflammation, and oxidatively modified molecules and organelles. Numerous pathways lead to brain aging, including increased ox...
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